応用薬物治療部門

昭和薬科大学研究室一覧

昭和薬科大学研究室一覧

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増田 豊教授 / 博士（薬学）last update : 2023.05.16

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研究者名
増田 豊（マスダ ユタカ）
所属
応用薬物治療部門
担当科目
臨床薬学II（3年）
多職種連携教育（4年）
臨床実習事前学習Ⅰ（4年前期）
臨床実習事前学習Ⅱ（4年後期）
薬物治療評価学（4年後期）
病院薬局実習（5年）
基礎薬学特論?演習（6年）
臨床薬学特論?演習（6年）
最終総合演習（6年）
職位
教授
学位
博士（薬学）

研究業績（著書）

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  • 衛生薬学　今井浩孝?小椋康光　編集　環境保全と法的規制　527-541　南江堂　2016　978-4-524-40317-2C3047

研究業績（論文）

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  • 原著論文　Effects of IgM anti-galnac-GD1a monoclonal antibodies on neuromuscular transmission and calcium channel binding in the rat neuromuscular junctions.　Hotta S, Nagaoka T, Nakatani Y, Kambe T, Abe K, Masuda Y, Utsumomiya I, Taguchi K　J Neurol Neurophysiol　6　275　2015　
  • 原著論文　Effects of IgG anti-GM1 monoclonal antibodies on neuromuscular transmission and calcium channel binding in the rat neuromuscular junctions.　Hotta S, Nakatani Y, Kambe T, Abe K, Masuda Y, Utsumomiya I, Taguchi K　Exp Ther Med　10　535-540　2015　
  • 原著論文　Hinesol, a compound isolated from essential oils of Atractylodes lancea rhizome, inhibits the cell growth and induces apoptosis in human leukemia HL-60 cells.　Masuda Y, Kadokura T, Ishii M, Takada K, Kitajima J　J Nat Med 　69　332-339　2015　
  • 原著論文　Capillin, a major constituent of Artemisia capillaris Thunb. flower essential oil, induces apoptosis through the mitochondrial pathway in human leukemia HL-60 cells.　Masuda Y, Asada K, Satoh R, Takada K, Kitajima J　Phytomedicine　22　545-552　2015　
  • 原著論文　PI3-kinase inhibitor LY294002 repress expression of thrombin-activatable fibrinolysis inhibitor in human hepatoma HepG2 cells.　Masuda Y, Yazawa J, Makino Y, Takada K　Biol Phram Bull　38　1529-1535　2015　
  • 原著論文　Neurophysiological and immunohistochemical studies of IgG anti-GM1 monoclonal antibody on neuromuscular transmission: effects in rat neuromuscular junctions.　Hotta S, Nagaoka T, Taguchi K, Nakatani Y, Utsnomiya I, Masuda Y, Abe K, Yuki N　Neurol sci 　35　205-213　2014　
  • 原著論文　Nobiletin, a polymethoxyflavone in citrus fruits, reduces TAFI expression in HepG2 cells through transcriptional inhibition.　Takada K, Seike T, Sasaki T, Masuda Y, Ito A, Ishii H　Thromb Haemost　109　1060-1069　2013　
  • 原著論文　Peroxisome proliferator-activated receptor-alpha agonists repress expression of thrombin-activatable fibrinolysis inhibitor by decreasing transcript stability.　Masuda Y, Saotome D, Takada K, Sugimoto K, Sasaki T, Ishii H　Thromb Haemost 　108　74-85　2012　
  • 総説　The role of mitochondrial chaperone tumor necrosis factor-associated protein 1 (TRAP1) in the regulation of apoptosis.　Masuda Y　Journal of Health Science　57　1-9　2011　
  • 総説　Vitamin K2 as a chemotherapeutic agent for treating ovarian cancer.　Nakaya, K., Masuda, Y., Aiuchi T., and Itabe H.　Ovarian Cancer/Book 　　259-274　2011　
  • 原著論文　Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver.　Takahashi K, Sasabe N, Ohshima K, Kitazato K, Kato R, Masuda Y, Tsurumaki M, Obama T, Okudaira S, Aoki J, Arai H, Yamaguchi T, Itabe H　J Lipid Res 　51　2571-2580　2010　
  • 総説　TRAP1: a regulator of mitochondrial functions and apoptosis.　Masuda Y. and Itabe H　Mitochondria: Structure, Functions and Dysfunctions　　927-940　2009　
  • 原著論文　Expression of thrombin-activatable fibrinolysis inhibitor (TAFI) is up-regulated by increase in intracellular cyclic AMP levels in cultured HepG2 cells.　Ishii H, Kojima Y, Masuda Y, Takada K, Sugimoto K, Ikeda T　Thromb Haemost 　102　1204-1211　2009　
  • 原著論文　Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappaB, AP-1, and Sp1 activation.　Hirata Y, Masuda Y, Kakutani H, Higuchi T, Takada K, Ito A, Nakagawa Y, Ishii H　Biochem Pharmacol　75　1504-1514　2008　
  • 原著論文　A tyrosine kinase inhibitor, beta-hydroxyisovalerylshikonin, induced apoptosis in human lung cancer DMS114 cells through reduction of dUTP nucleotidohydrolase activity.　Kajimoto S, Horie M, Manabe H, Masuda Y, Shibayama-Imazu T, Nakajo S, Gong XF, Obama T, Itabe H, Nakaya K　Biochim Biophys Acta　1782　41-50　2008　
  • 原著論文　A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation.　Matza D, Badou A, Kobayashi KS, Goldsmith-Pestana K, Masuda Y, Komuro A, McMahon-Pratt D, Marchesi VT, Flavell RA　Immunity　28　64-74　2008　
  • 原著論文　Induction of apoptosis in PA-1 ovarian cancer cells by vitamin K(2) is associated with an increase in the level of TR3/Nur77 and its accumulation in mitochondria and nuclei.　Sibayama-Imazu T, Fujisawa Y, Masuda Y, Aiuchi T, Nakajo S, Itabe H, Nakaya K　J Cancer Res Clin Oncol 　134　803-812　2008　
  • 原著論文　Involvement of Tiam1 in apoptosis induced by bufalin in HeLa cells.　Cao H, Shibayama-Imazu T, Masuda Y, Shinki T, Nakajo S, Nakaya K　Anticancer Res　27　245-249　2007　
  • 原著論文　Increase in intracellular Ca(2+) concentrations and the corresponding intracellular acidification are early steps for induction of apoptosis by geranylgeraniol in HL60 cells.　Masuda Y, Aiuchi T, Mihara S, Nakajo S, Nakaya K　Biol Pharm Bull 　30　880-884　2007　
  • 原著論文　Analysis of modified apolipoprotein B-100 structures formed in oxidized low-density lipoprotein using LC-MS/MS.　Obama T, Kato R, Masuda Y, Takahashi K, Aiuchi T, Itabe H　Proteomics　7　2132-2141　2007　
  • 原著論文　ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells.　Masuda Y, Itabe H, Odaki M, Hama K, Fujimoto Y, Mori M, Sasabe N, Aoki J, Arai H, Takano T　J Lipid Res　47　87-98　2006　
  • 原著論文　A novel 21-kDa cytochrome c-releasing factor is generated upon treatment of human leukemia U937 cells with geranylgeraniol.　Masuda Y, Maeda S, Watanabe A, Sano Y, Aiuchi T, Nakajo S, Itabe H, Nakaya K　Biochem Biophys Res Commun　346　454-460　2006　
  • 原著論文　The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells.　Komuro A*, Masuda Y*, Kobayashi K, Babbitt R, Gunel M, Flavell RA, Marchesi VT　Proc Natl Acad Sci U S A　101　4053-4058　2004　
  • 原著論文　Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. 　Masuda Y, Shima G, Aiuchi T, Horie M, Hori K, Nakajo S, Kajimoto S, Shibayama-Imazu T, Nakaya K　J Biol Chem　279　42503-42515　2004　
  • 原著論文　Recombinant curculin heterodimer exhibits taste-modifying and sweet-tasting activities.　Suzuki M, Kurimoto E, Nirasawa S, Masuda Y, Hori K, Kurihara Y, Shimba N, Kawai M, Suzuki E, Kato K　FEBS Lett　573　135-138　2004　
  • 原著論文　Beta-hydroxyisovalerylshikonin induces apoptosis in human leukemia cells by inhibiting the activity of a polo-like kinase 1 (PLK1).　Masuda Y, Nishida A, Hori K, Hirabayashi T, Kajimoto S, Nakajo S, Kondo T, Asaka M, Nakaya K　Oncogene　22　1012-1023　2003　
  • 原著論文　Costunolide triggers apoptosis in human leukemia U937 cells by depleting intracellular thiols.　Choi JH, Ha J, Park JH, Lee JY, Lee YS, Park HJ, Choi JW, Masuda Y, Nakaya K, Lee KT　Jpn J Cancer Res　93　1327-1333　2002　
  • 原著論文　Beta-hydroxyisovalerylshikonin is a novel and potent inhibitor of protein tyrosine kinases.　Hashimoto S, Xu Y, Masuda Y, Aiuchi T, Nakajo S, Uehara Y, Shibuya M, Yamori T, Nakaya K　Jpn J Cancer Res　93　944-951　2002　
  • 原著論文　Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores.　Kajimoto S, Takanashi N, Kajimoto T, Xu M, Cao J, Masuda Y, Aiuchi T, Nakajo S, Ida Y, Nakaya K　Int J Cancer　99　879-890　2002　
  • 原著論文　The mechanism of geranylgeraniol-induced apoptosis involves activation, by a caspase-3-like protease, of a c-Jun N-terminal kinase signaling cascade and differs from mechanisms of apoptosis induced by conventional chemotherapeutic drugs.　Masuda Y, Nakaya M, Aiuchi T, Hashimoto S, Nakajo S, Nakaya K　Leuk Res　24　937-950　2000　
  • 原著論文　beta-hydroxyisovalerylshikonin inhibits the cell growth of various cancer cell lines and induces apoptosis in leukemia HL-60 cells through a mechanism different from those of Fas and etoposide.　Hashimoto S, Xu M, Masuda Y, Aiuchi T, Nakajo S, Cao J, Miyakoshi M, Ida Y, Nakaya K　J Biochem (Tokyo)　125　17-23　1999　
  • 原著論文　Induction of apoptosis by bufalin in human tumor cells is associated with a change of intracellular concentration of Na+ ions.　Kawazoe N, Aiuchi T, Masuda Y, Nakajo S, Nakaya K　J Biochem (Tokyo) 　126　278-286　1999　
  • 原著論文　Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells.　Kawazoe N, Watabe M, Masuda Y, Nakajo S, Nakaya K　Oncogene　18　2413-2421　1999　
  • 原著論文　Analysis of caspases that are activated during apoptosis in leukemia U937 cells in response to geranylgeraniol.　Nakaya M, Masuda Y, Mihara S, Aiuchi T, Shibayama-Imazu T, Nakajo S, Nakaya K　Anticancer Res　19　5063-5068　1999　
  • 原著論文　Zinc ions prevent processing of caspase-3 during apoptosis induced by geranylgeraniol in HL-60 cells.　Aiuchi T, Mihara S, Nakaya M, Masuda Y, Nakajo S, Nakaya K　J Biochem (Tokyo)　124　300-303　1998　
  • 原著論文　Activation of AP-1 is required for bufalin-induced apoptosis in human leukemia U937 cells.　Watabe M, Ito K, Masuda Y, Nakajo S, Nakaya K　Oncogene　16　779-787　1998　
  • 原著論文　Bufalin reduces the level of topoisomerase II in human leukemia cells and affects the cytotoxicity of anticancer drugs.　Hashimoto S, Jing Y, Kawazoe N, Masuda Y, Nakajo S, Yoshida T, Kuroiwa Y, Nakaya K　Leuk Res　21　875-883　1997　
  • 原著論文　Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U937 cells.　Masuda Y, Nakaya M, Nakajo S, Nakaya K　Biochem Biophys Res Commun　234　641-645　1997　
  • 原著論文　Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells.　Masuda Y, Yoda M, Ohizumi H, Aiuchi T, Watabe M, Nakajo S, Nakaya K　Int J Cancer 　71　691-697　1997　
  • 原著論文　Induction of apoptosis in various tumor cell lines by geranylgeraniol.　Ohizumi H, Masuda Y, Yoda M, Hashimoto S, Aiuchi T, Nakajo S, Sakai I, Ohsawa S, Nakaya K　Anticancer Res　17　1051-1057　1997　
  • 原著論文　Galactose-inducible expression systems in Candida maltosa using promoters of newly-isolated GAL1 and GAL10 genes.　Park SM, Ohkuma M, Masuda Y, Ohta A, Takagi M　Yeast　13　21-29　1997　
  • 原著論文　Bcl-2 protein inhibits bufalin-induced apoptosis through inhibition of mitogen-activated protein kinase activation in human leukemia U937 cells.　Watabe M, Kawazoe N, Masuda Y, Nakajo S, Nakaya K　Cancer Res 　57　3097-3100　1997　
  • 原著論文　Complete nucleotide sequences of the genes encoding translation elongation factors 1 alpha and 2 from a microsporidian parasite, Glugea plecoglossi: implications for the deepest branching of eukaryotes.　Kamaishi T, Hashimoto T, Nakamura Y, Masuda Y, Nakamura F, Okamoto K, Shimizu M, Hasegawa M　J Biochem (Tokyo) 　120　1095-1103　1996　
  • 原著論文　Geranylgeraniol causes a decrease in levels of calreticulin and tyrosine phosphorylation of a 36-kDa protein prior to the appearance of apoptotic features in HL-60 cells.　Nakajo S, Okamoto M, Masuda Y, Sakai I, Ohsawa S, Nakaya K　Biochem Biophys Res Commun　226　741-745　1996　
  • 原著論文　Cloning and sequencing of a cDNA encoding a heat-stable sweet protein, mabinlin II.　Nirasawa S, Masuda Y, Nakaya K, Kurihara Y　Gene　181　225-227　1996　
  • 原著論文　Purification and characterization of bleomycin hydrolase, which represents a new family of cysteine proteases, from rat skin.　Takeda A, Higuchi D, Yamamoto T, Nakamura Y, Masuda Y, Hirabayashi T, Nakaya K　J Biochem (Tokyo) 　119　29-36　1996　
  • 原著論文　Cloning and analysis of cDNA encoding rat bleomycin hydrolase, a DNA-binding cysteine protease.　Takeda A, Masuda Y, Yamamoto T, Hirabayashi T, Nakamura Y, Nakaya K　J Biochem (Tokyo)　120　353-359　1996　
  • 原著論文　The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells.　Watabe M, Masuda Y, Nakajo S, Yoshida T, Kuroiwa Y, Nakaya K　J Biol Chem　271　14067-14072　1996　
  • 原著論文　Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells.　Masuda Y, Kawazoe N, Nakajo S, Yoshida T, Kuroiwa Y, Nakaya K　Leuk Res　19　549-556　1995　
  • 原著論文　Cloning and sequencing of a cDNA encoding a taste-modifying protein, miraculin.　Masuda Y, Nirasawa S, Nakaya K, Kurihara Y　Gene 　161　175-177　1995　
  • 原著論文　Cloning and characterization of the POX2 gene in Candida maltosa. 　Masuda Y, Park SM, Ohta A, Takagi M　Gene　167　157-161　1995　
  • 原著論文　Geranylgeraniol is a potent inducer of apoptosis in tumor cells.　Ohizumi H, Masuda Y, Nakajo S, Sakai I, Ohsawa S, Nakaya K　J Biochem (Tokyo)　117　11-13　1995　
  • 原著論文　Evidence that the expression of the gene for NADPH-cytochrome P-450 reductase is n-alkane-inducible in Candida maltosa.　Ohkuma M, Masuda Y, Park SM, Ohtomo R, Ohta A, Takagi M　Biosci Biotechnol Biochem　59　1328-1330　1995　
  • 原著論文　In vivo evidence for non-universal usage of the codon CUG in Candida maltosa.　Sugiyama H, Ohkuma M, Masuda Y, Park SM, Ohta A, Takagi M　Yeast　11　43-52　1995　
  • 原著論文　Selective inhibitory effect of bufalin on growth of human tumor cells in vitro: association with the induction of apoptosis in leukemia HL-60 cells.　Jing Y, Ohizumi H, Kawazoe N, Hashimoto S, Masuda Y, Nakajo S, Yoshida T, Kuroiwa Y, Nakaya K　Jpn J Cancer Res　85　645-651　1994　
  • 原著論文　Expression of an endogenous and a heterologous gene in Candida maltosa by using a promoter of a newly-isolated phosphoglycerate kinase (PGK) gene.　Masuda Y, Park SM, Ohkuma M, Ohta A, Takagi M　Curr Genet　25　412-417　1994　
  • 原著論文　Evolutionary position of n-alkane-assimilating yeast Candida maltosa shown by nucleotide sequence of small-subunit ribosomal RNA gene.　Ohkuma M, Hwang CW, Masuda Y, Nishida H, Sugiyama J, Ohta A, Takagi M　Biosci Biotechnol Biochem　57　1793-1794　1993　
  • 原著論文　Determination of the phosphorylation sites of calmodulin catalyzed by casein kinase 2　Nakajo S, Masuda Y, Nakaya K, Nakamura Y　J Biochem (Tokyo)　104　946-951　1988　

研究業績（学会発表等）

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  • ポスター発表　実務実習事前学習における学習者の態度評価の客観性と自己評価の検討　○福井楓、土肥弘久、萩原幸彦、堀口よし江、増田豊、北島潤一、高野昭人、千葉良子、濱島肇、濵本知之、廣原正宜、福森隆次、小野寺敏、渡部一宏、山本健、山本美智子　日本薬学会第１３６年会　横浜　2016/03/26?2016/03/29
  • 口頭発表　新規 TAFIa 阻害剤 7-Amino-2-(sulfanylmethyl) heptanoic acid の線溶促進作用　○ 高田公彦、佐々木知幸、杉本勝良、清家　亨、増田　豊、村山典恵、山崎浩史、吉本暢子、山本恵子、石井秀美　第13回 Pharmaco-Hematology シンポジウム　東京　2012/06/15?2012/06/16
  • ポスター発表　AP-1 は TAFI 発現に関わる調節因子であり、ノビレチンによる TAFI 発現抑制機序に関わる　○高田公彦、佐々木知幸、清家　亨、増田　豊、石井秀美　第34回日本血栓止血学会学術集会　東京　2012/06/07?2012/06/09

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