Profile

Name

Iwao Okamoto

Affiliation

Laboratory of Pharmaceutical Organic Chemistry

Subjects

Fundamental Organic Chemistry
Organic Chemistry

Official title

Professor

Degree

Ph.D.

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Papers

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• [Original paper]　Structures and Reactivities of N-Alkenyl-Substituted Anilides: The “Magic” Methyl Effect on Alkene.　Ryu Yamasaki, Mariko Ono, Kento Morita, Ai Ito, Kazuo Fukuda, Iwao Okamoto　J. Org. Chem.　88 (20)　14487–14493　2023　
• [Original paper]　Synthesis and conformational analysis of N-aromatic acetamides bearing thiophene: effect of intramolecular chalcogen-chalcogen interaction on amide conformational stability.　Ai Ito, Marino Asato, Yuki Asami, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto　J. Org. Chem.　88 (11)　7075–7087　2023　
• [Original paper]　Structure and Additive-free Transamidation of Planar N-Cyano Amides.　Ryu Yamasaki, Yuko Okada, Hiromi Iizumi, Ai Ito, Kazuo Fukuda, Iwao Okamoto　J. Org. Chem.　88 (9)　5704–5712　2023　
• [Original paper]　Reversible On/Off Conformational Switching of Pentafluorobenzoyl Amide Triggered by Acid Vapor and Sublimation　Ryu Yamasaki, Misuzu Harada, Ai Ito, Kazuo Fukuda, Shota Matsumoto, Satoru Karasawa, Iwao Okamoto　CrystEngComm　24 (35)　6226–6231　2022　
• [Original paper]　Conformational Switch of Benzanilide Derivative Induced by Acid; Effect of Pentafluorobenzoyl Group　Ryu Yamasaki, Misuzu Harada, Rino Nagata, Ai Ito, Kazuo Fukuda, Iwao Okamoto　J. Org. Chem.　87 (13)　8469–8479　2022　
• [Original paper]　Hybrid molecule between platanic acid and LCL-161 as a yes-associated protein degrader　Naoko Nakano, Kazuo Fukuda, Etsu Tashiro, Haruka Ishikawa, Waka Nagano, Rie Kawamoto, Alice Mori, Misao Watanabe, Ryu Yamazaki, Takahisa Nakane, Mikihiko Naito, Iwao Okamoto, Susumu Itoh　The Journal of Biochemistry　171 (6)　631–640　2022　
• [Original paper]　Synthesis and crystal structures of N,N-diarylacetamides bearing two azulene rings　Ai Ito, Mayuko Watanabe, Ayako Ishii, Ryu Yamasaki, Iwao Okamoto　Tetrahedron Lett.　86　Article 153523　2021　
• [Original paper]　Characterization of Push?Pull-Type Benzo[X]quinoline Derivatives (X = g or f): Environmentally Responsive Fluorescent Dyes with Multiple Functions　Yasufumi Fuchi, Tomohiro Umeno, Yuichiro Abe, Keita Ikeno, Ryu Yamasaki, Iwao Okamoto, Kazuteru Usui, Satoru Karasawa　J. Org. Chem.　85　13177–13190　2020　
• [Original paper]　Synthesis and conformational analysis of N-aryl-N-(6-azulenyl)acetamides　Ai Ito, Ayako Ishii, Takamasa Amaki, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto　Tetrahedron Lett.　60 (29)　1929-1933　2019　
• [Original paper]　N-Ethynylation of Anilides Decreases the Double-Bond Character of Amide Bond while Retaining trans-Conformation and Planarity　Ryu Yamasaki, Kento Morita, Hiromi Iizumi, Ai Ito, Kazuo Fukuda, Iwao Okamoto　Chem. Eur. J.　25 (43)　10118-10122　2019　
• [Original paper]　Conformational analysis of N-aryl-N-(2-azulenyl)acetamides　Ai Ito, Takamasa Amaki, Ayako Ishii, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto　Tetrahedron Lett.　59 (45)　3994-3998　2018　
• [Original paper]　Spontaneous and direct transformation of O-aryl-N-aryl carbamates into N,N’-diarylureas　Ryu Yamasaki, Yutaka Honjo, Ai Ito, Kazuo Fukuda, Iwao Okamoto　Chem. Pharm. Bull.　66 (9)　880-884　2018　
• [Original paper]　Symthesis and conformational analysis of N-aryl-N-(3-thienyl) acetamides　Ai Ito, Yuki Asami, Marino Asato, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto　Tetrahedron Lett.　59 (25)　2454–2458　2018　
• [Original paper]　Crystal engineering of N,N'-diphenylurea compounds featuring phenyl-perfluorophenyl interaction　Ryu Yamasaki, Mana Iida, Ai Ito, Kazuo Fukuda, Aya Tanatani, Hiroyuki Kagechika, Hyuma Masu, Iwao Okamoto　Cryst. Crowth Des.　17 (11)　5858–5866　2017　
• [Original paper]　Acid-controlled switching of conformational preference of N,N-diarylamides bearing pyridine.　Ai Ito, Hiroto Fujino, Keiko Ushiyama, Eriko Yamanaka, Ryu Yamasaki, Iwao Okamoto　Tetrahedron Lett.　57 (42)　4737-4741　2016　
• [Original paper]　Gold-Catalyzed Synthesis of 2-Substituted Azepanes: Strategic Use of Soft Gold(I) and Hard Gold(III) Catalysts.　Nobuyoshi Morita, Yuta Saito, Ayumi Muraji, Shintaro Ban, Yoshimitsu Hashimoto, Iwao Okamoto, Osamu Tamura　Synlett　27 (13)　1936-1940　2016　
• [Original paper]　Gold-Catalyzed Dimeric Cyclization of Isoeugenol and Related 1-Phenylpropenes in Ionic Liquid: Environmentally Friendly and Stereoselective Synthesis of 1,2,3-Trisubstituted 2,3-Dihydro-1H-indenes.　Nobuyoshi Morita, Rie Mashiko, Dai Hakuta, Daisuke Eguchi, Shintaro Ban, Yoshimitsu Hashimoto, Iwao Okamoto, Osamu Tamura　Synthesis　48 (12)　1927-1933　2016　
• [Original paper]　Acid-induced molecular-structural transformation of N-methyl aromatic oligoamides bearing pyridine-2-carboxamide　Ryu Yamasaki, Saori Fujikake, Ai Ito, Kentaro Migita, Nobuyoshi Morita, Osamu Tamura, and Iwao Okamoto　Tetrahedron Lett.　57(1)　56-59　2016　
• [Original paper]　Acid- and base-induced conformational alternations of N-aryl-N-troponyl amides　Ai Ito, Masanori Sato, Ryu Yamasaki, and Iwao Okamoto　Tetrahedron Lett.　57(3)　438-441　2016　
• [Original paper]　BF3?Mediated cis-Selective Cycloaddition of O?Silyloxime with Alkenes　Nobuyoshi Morita, Rina Kono, Kenji Fukui, Asuka Miyazawa, Hyuma Masu, Isao Azumaya, Shintaro Ban, Yoshimitsu Hashimoto, Iwao Okamoto, Osamu Tamura　J. Org. Chem.　80 (9)　4797–4802　2015　
• [Original paper]　Gold(I)/(III)-Catalyzed Synthesis of Cyclic Ethers; Valency-Controlled Cyclization Modes　Nobuyoshi Morita, Arisa Yasuda, Motohiro Shibata, Shintaro Ban, Yoshimitsu Hashimoto, Iwao Okamoto, Osamu Tamura　Org. Lett.　17 (11)　2668–2671　2015　
• [Original paper]　Gold(I)/(III)-catalyzed synthesis of 2-substituted piperidines; valencycontrolled cyclization modes　Nobuyoshi Morita, Tomonori Tsunokake, Yuji Narikiyo, Mayuka Harada, Tatsuyuki Tachibana, Yuta Saito, Shintaro Ban, Yoshimitsu Hashimoto, Iwao Okamoto, Osamu Tamura　Tetrahedron Lett.　56 (45)　6269–6272　2015　
• [Original paper]　Solvent-dependent Conformational and Fluorescence Change of an N-Phenylbenzohydroxamic Acid Derivative Bearing Two Pyrene Moieties　Misae Kanai, Tomoya Hirano, Isao Azumaya, Iwao Okamoto, Hiroyuki Kagechika, Aya Tanatani　Tetrahedron　68 (13)　2778–2783　2012　
• [Original paper]　Redox-Responsive Conformational Alteration of Aromatic Amides Bearing N-Quinonyl System　Iwao Okamoto, Yusuke Takahashi, Mika Sawamura, Mio Matsumura, Hyuma Masu, Kosuke Katagiri, Isao Azumaya, Masanori Nishino, Yukari Kohama, Nobuyoshi Morita, Osamu Tamura, Hiroyuki Kagechika, Aya Tanatani　Tetrahedron　68 (27-28)　5346–5355　2012　
• [Original paper]　Synthesis and Biological Evaluation of Tubulysin D Analogues Related to Stereoisomers of Tubuvaline　Taku Shibue, Iwao Okamoto, Nobuyoshi Morita, Hiroshi Morita, Yusuke Hirasawa, Takahiro Hosoya, Osamu Tamura　Bioorg. Med. Chem. Lett.　21 (1)　431–434　2011　
• [Original paper]　Synthesis of the proposed structure of phaeosphaeride A　Kenichi Kobayashi, Iwao Okamoto, Nobuyoshi Morita, Tamiko Kiyotani, Osamu Tamura　Org. Biomol. Chem.　9 (16)　5825–5832　2011　
• [Original paper]　Stereoselective vinylogous Mannich reaction of 2-trimethylsilyloxyfuran with N-gulosyl nitrones　Osamu Tamura, Kodai Takeda, NakaMita, Masanori Sakamoto, Iwao Okamoto, Nobuyoshi Morita, Hiroyuki Ishibashi　Org. Biomol. Chem.　9 (21)　7411–7419　2011　
• [Original paper]　Convenient Synthesis of Aminopyridinecarboxylic Acids　Iwao Okamoto, Masayuki Terashima, Rempei Yoshioka, Tomonori Muramatsu, Satomi Kojima, Haruka Inoue, Mio Takahashi, Nobuyoshi Morita, and Osamu Tamura　Heterocycles　83 (10)　2343–2352　2011　
• [Original paper]　Acid-Induced Conformational Alteration of cis-Preferential Aromatic Amides Bearing N-Methyl-N-(2-pyridyl) Moiety　Iwao Okamoto, Masayuki Terashima, Hyuma Masu, Mayumi Nabeta, Kaori Ono, Nobuyoshi Morita, Kosuke Katagiri, Isao Azumaya, Osamu Tamura　Tetrahedron　67 (44)　8536–8543　2011　

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