??.z%R ?0?0?0?0 W?? ?? T ?]?S ?0?0?0 ?QHrt^ DOI URL "[Original Paper] " "Discovery of a cystathionine ?-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation." "Echizen H., Hanaoka K., Shimamoto K., Hibi R., Toma-Fukai S., Ohno H., Sasaki E., Komatsu T., Ueno T., Tsuchiya Y., Watanabe Y., Otsuka T., Saito H., Nagatoishi S., Tsumoto K., Kojima H., Okabe T., Shimizu T., Urano Y." "Sci Rep" 13 16456 2023 10.1038/s41598-023-43536-6 https://pubmed.ncbi.nlm.nih.gov/37777556/ "[Original Paper] " "Cystathionine ?-Lyase Self-Inactivates by Polysulfidation during Cystine Metabolism" "Shoma Araki, Tsuyoshi Takata, Katsuhiko Ono, Tomohiro Sawa, Shingo Kasamatsu, Hideshi Ihara, Yoshito Kumagai, Takaaki Akaike, Yasuo Watanabe, Yukihiro Tsuchiya" "Int J Mol Sci " 24 9982 2023 10.3390/ijms24129982 https://pubmed.ncbi.nlm.nih.gov/37373128/ "[Original Paper] " "Angiogenesis in the Outer Membrane of Chronic Subdural Hematomas through Thrombin-Cleaved Osteopontin and the Integrin ?9 and Integrin ?1 Signaling Pathways" "Koji Osuka, Yusuke Ohmichi, Mika Ohmichi, Satoru Honma, Chiharu Suzuki, Masahiro Aoyama, Kenichiro Iwami, Yasuo Watanabe, Shigeru Miyachi" Biomedicines 24 1440 2023 10.3390/biomedicines11051440 https://pubmed.ncbi.nlm.nih.gov/37239111/ "[Original Paper]" "Regulation of nitric oxide/reactive oxygen species redox signaling by nNOS splicing variants" "Shingo Kasamatsu , Hiroyasu Tsutsuki, Tomoaki Ida, Tomohiro Sawa, Yasuo Watanabe, Takaaki Akaike, Hideshi Ihara" "Nitric Oxide ." 120 44-52 2022 10.1016/j.niox.2022.01.004 https://pubmed.ncbi.nlm.nih.gov/35033681/ "[Original Paper]" "Sequential expression of neutrophil chemoattractants in cerebrospinal fluid after subarachnoid hemorrhage." "Koji Osuka, Yasuo Watanabe, Chiharu Suzuki, Kenichiro Iwami, Shigeru Miyachi" "Journal of neuroimmunology" 357 577610-577610 2021 10.1016/j.jneuroim.2021.577610 https://pubmed.ncbi.nlm.nih.gov/34030107/ "[Original Paper]" "Sequential Expression of Chemokines in Chronic Subdural Hematoma Fluids after Trepanation Surgery." "Koji Osuka, Yusuke Ohmichi, Mika Ohmichi, Takahiro Nakura, Kenichiro Iwami, Yasuo Watanabe, Shigeru Miyachi" "Journal of neurotrauma" 38 1979-1987 2021 10.1089/neu.2020.7401 https://pubmed.ncbi.nlm.nih.gov/33497585/ [Review] "Oxidative Stress Orchestrates MAPK and Nitric-Oxide Synthase Signal" "Tsuyoshi Takata, Shoma Araki, Yukihiro Tsuchiya, Yasuo Watanabe" "Int J Mol Sci" 21 8750 2020 10.3390/ijms21228750 https://www.mdpi.com/1422-0067/21/22/8750 "[Original Paper]" "PPAR? Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates" "Kamata S, Oyama T, Saito K, Honda A, Yamamoto Y, Suda K, Ishikawa R, Itoh T, Watanabe Y, Shibata T, Uchida K, Suematsu M, Ishii I." iScience 23 101727 2020 10.1016/j.isci.2020.101727 https://pubmed.ncbi.nlm.nih.gov/33205029/ "[Review](Cover image: Related links)" "Coordination between Calcium/Calmodulin-Dependent Protein Kinase II and Neuronal Nitric Oxide Synthase in Neurons" "Shoma Araki, Koji Osuka, Tsuyoshi Takata,Yukihiro Tsuchiya, Yasuo Watanabe" "Int J Mol Sci" 21 7997- 2020 10.3390/ijms21217997 https://www.mdpi.com/1422-0067/21/21 [Review] "Persulfide signaling in stress-initiated CaM kinase response." "Tsuyoshi Takata, Shoma Araki, Yukihiro Tsuchiya, Yasuo Watanabe" "Antioxidants & redox signaling" 33 1308-1319 2020 10.1089/ars.2020.8138 https://www.ncbi.nlm.nih.gov/pubmed/32460522 "[Original Paper] " "Expression of high mobility group B1 and toll-like receptor-nuclear factor ?B signaling pathway in chronic subdural hematomas" "Koji Osuka , Yasuo Watanabe, Nobuteru Usuda, Kenichiro Iwami, Shigeru Miyachi, Masakazu Takayas" "PloS one" 15(6) e0233643 2020 10.1371/journal.pone.0233643 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263617 "[Original Paper]" "The active-site cysteine residue of Ca2+/calmodulin-dependent protein kinase I is protected from irreversible modification via generation of polysulfidation" "Takata T, Tsukuda A, Tsuchiya Y, Akaike T, Watanabe Y." "Nitric Oxide" 86 68 75 2019 10.1016/j.niox.2019.02.008 https://www.sciencedirect.com/science/article/pii/S1089860318303355?dgcid=author "[Original Paper]" "Reactive sulfur species impair Ca2+/calmodulin-dependent protein kinase II via polysulfidation" "Araki S, Takata T, Tsuchiya Y, Watanabe Y." "Biochem. Biophys. Res. Commun." "508 " 550-555 2019 10.1016/j.bbrc.2018.11.134 https://www.ncbi.nlm.nih.gov/pubmed/30509490 "[Original Paper]" "Redox regulation of Ca2+/calmodulin-dependent protein kinase IV via oxidation of its active-site cysteine residue" "Takata T, Kimura J, Ihara H, Hatano N, Tsuchiya Y, Watanabe Y." "Free Radic. Biol. Med. " 130 "99-106 " 2019 "10.1016/j.freeradbiomed.2018.10.440 " https://www.ncbi.nlm.nih.gov/pubmed/30394289 "[Original Paper]" "Expression of Autophagy Signaling Molecules in the Outer Membranes of Chronic Subdural Hematomas." "Osuka K, Watanabe Y, Usuda N, Aoyama M, Takeuchi M, Takayasu M." "J. Neurotrauma" 36 403-407 2019 "10.1089/neu.2018.5626 " https://www.ncbi.nlm.nih.gov/pubmed/30106666 "[Original Paper]" " Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons. " "Masuda K, Tsutsuki H, Kasamatsu S, Ida T, Takata T, Sugiura K, Nishida M, Watanabe Y, Sawa T, Akaike T, Ihara H." "Biochem. Biophys. Res. Commun." "495 " "2165-2170 " 2018 10.1016/j.bbrc.2017.12.088 https://www.ncbi.nlm.nih.gov/pubmed/29258821 "[Original Paper]" "Subarachnoid hemorrhage induces neuronal nitric oxide synthase phosphorylation at Ser1412 in the dentate gyrus of the rat brain." "Wada K, Osuka K, Watanabe Y, Usuda N, Fukasawa M, Araki Y, Okamoto S, Wakabayashi T." "Nitric Oxide" 81 67-74 "2018 " 10.1016/j.niox.2017.10.007 https://www.ncbi.nlm.nih.gov/pubmed/29074292 "[Original Paper]" "Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics." " Akaike T, Ida T, Wei FY, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H." "Nat Commun." 8 1177 2017 10.1038/s41467-017-01311-y https://www.ncbi.nlm.nih.gov/pubmed/29079736 "[Original Paper]" "Inhibitory Mechanism of the Outer Membrane Growth of Chronic Subdural Hematomas. " "Osuka K, Watanabe Y, Usuda N, Aoyama M, Iwami K, Takeuchi M, Watabe T, Takayasu M. " "J Neurotrauma. " 34 "1996-2000. " 2017 10.1089/neu.2016.4623 https://www.ncbi.nlm.nih.gov/pubmed/28027695 "[Original Paper]" "1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides. " "Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y. " "Free Radic Biol Med. " 104 118-128. 2017 10.1016/j.freeradbiomed.2016.12.047 https://www.ncbi.nlm.nih.gov/pubmed/28049024 "[Original Paper]" "Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide. " "Hanaoka K, Sasakura K, Suwanai Y, Toma-Fukai S, Shimamoto K, Takano Y, Shibuya N, Terai T, Komatsu T, Ueno T, Ogasawara Y, Tsuchiya Y, Watanabe Y, Kimura H, Wang C, Uchiyama M, Kojima H, Okabe T, Urano Y, Shimizu T, Nagano T. " "Sci Rep. " 7 40227. 2017 10.1038/srep40227 https://www.ncbi.nlm.nih.gov/pubmed/28079151 "[Original Paper]" "Superoxide generation from nNOS splice variants and its potential involvement in redox signal regulation. " "Ihara H, Kitamura A, Kasamatsu S, Ida T, Kakihana Y, Tsutsuki H, Sawa T, Watanabe Y, Akaike T. " "Biochem J. " 474 1149-1162. 2017 10.1042/BCJ20160999 https://www.ncbi.nlm.nih.gov/pubmed/28126743 "[Original Paper]" "Activation of Nuclear Factor-kappa B in Endothelial Cells of Chronic Subdural Hematoma Outer Membranes. " "Osuka K, Watanabe Y, Usuda N, Aoyama M, Kawaguchi R, Takeuchi M, Takayasu M. " "Neurosurgery. " 80 571-578. 2017 10.1093/neuros/nyw100 https://www.ncbi.nlm.nih.gov/pubmed/28362919 "[Original Paper]" "Reactive sulfur species inactivate Ca2+/calmodulin-dependent protein kinase IV via S-polysulfidation of its active-site cysteine residue.000" "Takata T, Ihara H, Hatano N, Tsuchiya Y, Akaike T, Watanabe Y.00" "Biochem J." 474 2547-2562. 2017 10.1042/BCJ20170092 https://www.ncbi.nlm.nih.gov/pubmed/28637792 "[Original Paper]" "Expression of Caspase Signaling Components in the Outer Membranes of Chronic Subdural Hematomas.0" "Osuka K, Watanabe Y, Usuda N, Aoyama M, Iwami K, Takeuchi M, Watabe T, Takayasu M.0" "J Neurotrauma." 34 3192-3197 2017 10.1089/neu.2017.5051 https://www.ncbi.nlm.nih.gov/pubmed/28661222 "[Original paper]" "Activation of STAT3 in endothelial cells of chronic subdural hematoma outer membranes" "Osuka K, Watanabe Y, Usuda N, Aoyama M, Kawaguchi R, Watabe T, Takayasu M." "World Neurosurg." 91 376-382 2016 10.1016/j.wneu.2016.04.025 http://www.ncbi.nlm.nih.gov/pubmed/27102635 [Review] "Regulation of calsium signals via redox modification" "Watanabe Y." "Folia Pharmacol. Jpn (Japanese)" 147 285-289 2016 10.1254/fpj.147.285 https://www.jstage.jst.go.jp/article/fpj/147/5/147_285/_article/-char/ja/ "[Original paper]" "Expressions of Mitogen-Activated Protein Kinases in Chronic Subdural Hematoma Outer membranes" "Aoyama M, Osuka K, Usuda N, Watanabe Y, Kawaguchi R, Nakura T, Takayasu M." "J Neurotrauma." 15 1064-1070 2015 10.1089/neu.2014.3594 http://www.ncbi.nlm.nih.gov/pubmed/25496293 "[Original paper]" "Increased ICP promotes CaMKII-mediated phosphorylation of neuronal NOS at Ser847 in the hippocampus immediately after subarachnoid hemorrhage" "Makino K, Osuka K, Watanabe Y, Usuda N, Hara M, Aoyama M, Takayasu M, Wakabayashi T." "Brain Res." 1616 19-25 2015 10.1016/j.brainres.2015.04.048 http://www.ncbi.nlm.nih.gov/pubmed/25940762 "[Original paper]" "Formation of Sulfur Adducts of N-Acetyl-p-benzoquinoneimine, an Electrophilic Metabolite of Acetaminophen in Vivo: Participation of Reactive Persulfides" "Abiko Y, Ishii I, Kamata S, Tsuchiya Y, Watanabe Y, Ihara H, Akaike T, Kumagai Y." "Chem Res Toxicol." 28 1796-1802 2015 10.1021/acs.chemrestox.5b00245 http://www.ncbi.nlm.nih.gov/pubmed/26304691 "[Original paper]" "Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons." "Kasamatsu S, Watanabe Y, Sawa T, Akaike T, Ihara H." "Biochem J." 459 251-263 2014 10.1042/BJ20131262 http://www.ncbi.nlm.nih.gov/pubmed/24499461 "[Original paper]" "Eotaxin-3 activates Smad through the TGF-?1 pathway in chronic subdural hematoma outer membranes." "Osuka K, Watanabe Y, Usuda N, Aoyama M, Takeuchi M, Takayasu M." "J Neurotrauma." 31 1451-1456 2014 10.1089/neu.2013.3195 http://www.ncbi.nlm.nih.gov/pubmed/24684589 "[Original paper]" "Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling." "Ida T, Sawa T, Ihara H, Tsuchiya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S, Matsunaga T, Yamamoto M, Ono K, Devarie-Baez NO, Xian M, Fukuto JM, Akaike T." "Proc Natl Acad Sci U S A." 111 7606-7611 2014 10.1073/pnas.1321232111 http://www.ncbi.nlm.nih.gov/pubmed/24733942 "[Original paper]" "Expression of suppressor of cytokine signaling 3 in cerebrospinal fluid after subarachnoid hemorrhage" "Osuka K, Watanabe Y, Aoyama M, Nakura T, Matsuo N, Takayasu M." "J Neuroinflammation." 11 142 2014 10.1186/s12974-014-0142-2 http://www.ncbi.nlm.nih.gov/pubmed/25125049 "[Original paper]" "Activation of JAK-STAT3 signaling pathway in chronic subdural hematoma outer membranes" "Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Shima H, Takeuchi M, Yasuda M, Takayasu M." "Neurosci Lett." 534 166"170 2013 10.1016/j.neulet.2012.11.011 http://www.ncbi.nlm.nih.gov/pubmed/23174178 "[Original paper]" "90-kDa ribosomal S6 kinase 1 is inhibited by S-glutathionylation of its active-site cysteine residue during oxidative stress " "Takata T, Tsuchiya Y, Watanabe Y." "FEBS Lett." 587 1681-1686 2013 10.1016/j.febslet.2013.04.017 http://www.ncbi.nlm.nih.gov/pubmed/23624076 "[Original paper]" "Nitric oxide enhances increase in cytosolic Ca2+ and promotes nicotine-triggered MAPK pathway in PC12 cells." "Kajiwara A, Tsuchiya Y, Takata T, Nyunoya M, Nozaki N, Ihara H, Watanabe Y." "Nitric Oxide." 34 3"9 2013 10.1016/j.niox.2013.04.002 http://www.ncbi.nlm.nih.gov/pubmed/23624270 "[Original paper]" "Phosphorylation of neuronal nitric oxide synthase at Ser1412 in the dentate gyrus of rat brain after transient forebrain ischemia." "Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Takayasu M." "Neurochem Int." 63 269-274 2013 10.1016/j.neuint.2013.06.011 http://www.ncbi.nlm.nih.gov/pubmed/23806217 "[Original paper]" "Adiponectin activates endothelial nitric oxide synthase through AMPK signaling after subarachnoid hemorrhage." "Osuka K, Watanabe Y, Yasuda M, Takayasu M." "Neurosci Lett." 514 2"5 2012 10.1016/j.neulet.2011.12.041 http://www.ncbi.nlm.nih.gov/pubmed/22230897 "[Original paper]" "Nitric oxide prevents phosphorylation of neuronal nitric oxide synthase at Serine1412 by inhibiting the Akt/PKB and CaM-K II signaling pathways" "Song T, Hatano N, Sugimoto K, Horii M, Yamaguchi F, Tokuda M, Miyamoto Y, Kambe T, Watanabe Y." "Int J Mol Med." 30 15-20 2012 10.3892/ijmm.2012.971 http://www.ncbi.nlm.nih.gov/pubmed/22576624 "[Original paper]" "Real-time monitoring of liver damage during ischemia-reperfusion using a nitric oxide-selective sensor in rat liver" "Nakagawa A, Yokoyama Y, Suzuki H, Shoji K, Watanabe Y, Imamura A, Kokuryo T, Nagino M." "Br J Surg." 99 1120-1128 2012 10.1002/bjs.8817 http://www.ncbi.nlm.nih.gov/pubmed/22622706 "[Original paper]" "Activation of Ras/MEK/ERK signaling in chronic subdural hematoma outer membranes" "Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Aoyama M, Niwa A, Nakura T, Takayasu M." "Brain Res." 13 98-103 2012 10.1016/j.brainres.2012.10.013 http://www.ncbi.nlm.nih.gov/pubmed/23063714 "[Original paper]" "Calcium/calmodulin-dependent protein kinases as potential targets of nitric oxide" "Takata T, Kimura J, Tsuchiya Y, Naito Y, Watanabe Y." "Nitric Oxide." 25 145-152 2011 10.1016/j.niox.2011.01.004 http://www.ncbi.nlm.nih.gov/pubmed/21255668 "[Original paper]" "Activation of PI3 kinase / Akt signaling in chronic subdural hematoma outer membranes. " "Funai M, Osuka K, Usuda N, Atsuzawa K, Inukai T, Yasuda M, Watanabe Y, Takayasu M." "J Neurotrauma." 28 1127-1131 2011 10.1089/neu.2010.1498 http://www.ncbi.nlm.nih.gov/pubmed/21309701 "[Original paper]" "Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation" "Butturini E, Cavalieri E, de Prati AC, Darra E, Rigo A, Shoji K, Murayama N, Yamazaki H, Watanabe Y, Suzuki H, Mariotto S." "PLoS One." 6 e20174 2011 10.1371/journal.pone.0020174 http://www.ncbi.nlm.nih.gov/pubmed/21625597 "[Original paper]" "Nitric oxide promotes nicotine-triggered ERK signaling via redox reactions in PC12 cells" "Miyamoto Y, Sakai R, Maeda C, Takata T, Ihara H, Tsuchiya Y, Watanabe Y." "Nitric Oxide." 25 344-349 2011 10.1016/j.niox.2011.06.006 http://www.ncbi.nlm.nih.gov/pubmed/21742048 "[Original paper]" "Activation of STAT1 in neurons following spinal cord injury in mice" "Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Yasuda M, Aoshima C, Wakabayashi T, Takayasu M." "Neurochem Res. " 36 2236-2243 2011 10.1007/s11064-011-0547-6 http://www.ncbi.nlm.nih.gov/pubmed/21833847 "[Original paper]" "Hypothermia enhances the colocalization of calmodulin kinase II? with neuronal nitric oxide synthase in the hippocampus following cerebral ischemia" "Hayashi S, Osuka K, Watanabe Y, Yasuda M, Takayasu M, Wakabayashi T." "Neurosci Lett. " 505 228-232 2011 10.1016/j.neulet.2011.10.013 http://www.ncbi.nlm.nih.gov/pubmed/22015767 "[Original Paper]" "Oxidative stress activates STAT1 in basilar arteries after subarachnoid hemorrhage. " "Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Wakabayashi T, Takayasu M. " "Brain Res." 1332 "12-19. " 2010 10.1016/j.brainres.2010.03.046 https://www.ncbi.nlm.nih.gov/pubmed/20307504 "[Original paper]" "Inactivation of Ca2+/Calmodulin-dependent Protein Kinase I by S-Glutathionylation of the Active-site Cysteine Residue." "Kambe T., Song T., Takata T., Hatano N., Miyamoto Y., Nozaki N., Naito Y., Tokumitsu H., Watanabe Y. " "FEBS Lett. " 584 2478-2484 2010 10.1016/j.febslet.2010.04.059. http://www.ncbi.nlm.nih.gov/pubmed/20420839 "[Original Paper]" "Modification of endothelial nitric oxide synthase through AMPK after experimental subarachnoid hemorrhage. " "Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Yoshida J, Takayasu M. " "J Neurotrauma. " "26 " "1157-65. " 2009 "10.1089/neu.2008-0836 " https://www.ncbi.nlm.nih.gov/pubmed/19226196 "[Original Paper]" "Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II. " "Song T, Hatano N, Kambe T, Miyamoto Y, Ihara H, Yamamoto H, Sugimoto K, Kume K, Yamaguchi F, Tokuda M, Watanabe Y. " "Biochem J. " 412 "223-31. " 2008 "10.1042/BJ20071195 " https://www.ncbi.nlm.nih.gov/pubmed/18271754 "[Original Paper]" "?SW???e Activation of endothelial nitric oxide synthase following spinal cord injury in mice. " "Osuka K, Watanabe Y, Takagi T, Usuda N, Atsuzawa K, Yoshida J, Takayasu M. " "Neurosci Lett. " 436 "265-8. " 2008 "10.1016/j.neulet.2008.03.039 " https://www.ncbi.nlm.nih.gov/pubmed/18400399 "[Original Paper]" "p90 RSK-1 associates with and inhibits neuronal nitric oxide synthase. " "Song T, Sugimoto K, Ihara H, Mizutani A, Hatano N, Kume K, Kambe T, Yamaguchi F, Tokuda M, Watanabe Y. " "Biochem J. " 401 "391-8. " 2007 https://www.ncbi.nlm.nih.gov/pubmed/16984226 "[Original Paper]" "Nitric oxide production in the ventilatory muscles in response to acute resistive loading. " "Vassilakopoulos T, Govindaraju K, Parthenis D, Eidelman DH, Watanabe Y, Hussain SN. " "Am J Physiol Lung Cell Mol Physiol. " 292 "L1013-22. " 2007 https://www.ncbi.nlm.nih.gov/pubmed/17189323 "[Original Paper]" "Phosphorylation of neuronal nitric oxide synthase at Ser847 in the nucleus intermediolateralis after spinal cord injury in mice. " "Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Aoshima C, Yamauchi K, Takayasu M, Yoshida J. " "Neuroscience. " 24 " 1-7 " 2007 https://www.ncbi.nlm.nih.gov/pubmed/17258865 "[Original Paper]" "Phosphoinositide metabolism during membrane ruffling and macropinosome formation in EGF-stimulated A431 cells. " "Araki N, Egami Y, Watanabe Y, Hatae T. " "Exp Cell Res. " 313 "1496-507 " 2007 https://www.ncbi.nlm.nih.gov/pubmed/17368443 "[Original Paper]" "Phosphorylation of neuronal and endothelial nitric oxide synthase in the kidney with high and low salt diets. " "Mount PF, Fraser SA, Watanabe Y, Lane N, Katsis F, Chen ZP, Kemp BE, Power DA. " "Nephron Physiol. " 102 "p36-50. " 2006 https://www.ncbi.nlm.nih.gov/pubmed/16244499 "[Original Paper]" "Activation of the JAK-STAT signaling pathway in the rat basilar artery after subarachnoid hemorrhage. " "Osuka K, Watanabe Y, Yamauchi K, Nakazawa A, Usuda N, Tokuda M, Yoshida J. " "Brain Res. " 1072 "1-7. " 2006 https://www.ncbi.nlm.nih.gov/pubmed/16413512 "[Original Paper]" "Clinical significance of Skp2 expression, alone and combined with Jab1 and p27 in epithelial ovarian tumors. " "Sui L, Dong Y, Watanabe Y, Yamaguchi F, Sugimoto K, Tokuda M. " "Oncol Rep. " 15 "765-71. " 2006 https://www.ncbi.nlm.nih.gov/pubmed/16525656 "[Original Paper]" "Alteration and clinical relevance of PTEN expression and its correlation with survivin expression in epithelial ovarian tumors." "Sui L, Dong Y, Watanabe Y, Yamaguchi F, Sugimoto K, Tokuda M." "Oncol Rep. " 15 "773-8. " 2006 https://www.ncbi.nlm.nih.gov/pubmed/16525657 "[Original Paper]" "Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. " "Nishi A, Watanabe Y, Higashi H, Tanaka M, Nairn AC, Greengard P. " "Proc Natl Acad Sci U S A. " 102 "1199-204. " 2005 https://www.ncbi.nlm.nih.gov/pubmed/15657149 "[Original Paper]" "Prognostic significance of Jab1 expression in laryngeal squamous cell carcinomas. " "Dong Y, Sui L, Watanabe Y, Yamaguchi F, Hatano N, Tokuda M. " "Clin Cancer Res. " 11 "259-66. " 2005 https://www.ncbi.nlm.nih.gov/pubmed/15671554 "[Original Paper]" "Growth inhibitory effect of D-allose on human ovarian carcinoma cells in vitro. " "Sui L, Dong Y, Watanabe Y, Yamaguchi F, Hatano N, Izumori K, Tokuda M. " "Anticancer Res. " 25 "2639-44. " 2005 https://www.ncbi.nlm.nih.gov/pubmed/16080505 "[Original Paper]" "The inhibitory effect and possible mechanisms of D-allose on cancer cell proliferation." " Sui L, Dong Y, Watanabe Y, Yamaguchi F, Hatano N, Tsukamoto I, Izumori K, Tokuda M." " Int J Oncol. " 27 "907-12. " 2005 https://www.ncbi.nlm.nih.gov/pubmed/16142305 "[Original Paper]" "Inhibition of neuronal nitric-oxide synthase by phosphorylation at Threonine1296 in NG108-15 neuronal cells. " "Song T, Hatano N, Kume K, Sugimoto K, Yamaguchi F, Tokuda M, Watanabe Y." "FEBS Lett. " "579 " "5658-62. " 2005 https://www.ncbi.nlm.nih.gov/pubmed/16214135 "[Original Paper]" "Neuroprotective effect of D-psicose on 6-hydroxydopamine-induced apoptosis in rat pheochromocytoma (PC12) cells. " "Takata MK, Yamaguchi F, Nakanose K, Watanabe Y, Hatano N, Tsukamoto I, Nagata M, Izumori K, Tokuda M. " "J Biosci Bioeng. " "100 " "511-6. " 2005 https://www.ncbi.nlm.nih.gov/pubmed/16384789 "[Original Paper]" "Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei. " "Agostino PV, Ferreyra GA, Murad AD, Watanabe Y, Golombek DA. " "Neurochem Int. " 44 "617-25. " 2004 https://www.ncbi.nlm.nih.gov/pubmed/15016477 "[Original Paper]" "Tyrosine phosphorylation of NOS3 in a breast cancer cell line and Src-transformed cells. " "Takenouchi Y, Oo ML, Senga T, Watanabe Y, Machida K, Miyazaki K, Nimura Y, Hamaguchi M. " "Oncol Rep. " 11 "1059-62. " 2004 https://www.ncbi.nlm.nih.gov/pubmed/15069547 "[Original Paper]" "Phosphohippolin expression in the rat central nervous system. " "Kadowaki K, Sugimoto K, Yamaguchi F, Song T, Watanabe Y, Singh K, Tokuda M. " "Brain Res Mol Brain Res. " 125 "105-12. " 2004 https://www.ncbi.nlm.nih.gov/pubmed/15193427 "[Original Paper]" "Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation. " "Song T, Hatano N, Horii M, Tokumitsu H, Yamaguchi F, Tokuda M, Watanabe Y. " "FEBS Lett. " 570 "133-7. " 2004 https://www.ncbi.nlm.nih.gov/pubmed/15251453 "[Original Paper]" "Modification of endothelial NO synthase through protein phosphorylation after forebrain cerebral ischemia/reperfusion. " "Osuka K, Watanabe Y, Usuda N, Nakazawa A, Tokuda M, Yoshida J. " Stroke 35 "2582-6. " 2004 https://www.ncbi.nlm.nih.gov/pubmed/15375304 "[Original Paper]" "S-phase kinase-associated protein 2 expression in laryngeal squamous cell carcinomas and its prognostic implications." " Dong Y, Sui L, Watanabe Y, Sugimoto K, Tokuda M. " "Oncol Rep. " "10 " "321-5. " 2003 https://www.ncbi.nlm.nih.gov/pubmed/12579266 "[Original Paper]" "Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase. " "Watanabe Y, Song T, Sugimoto K, Horii M, Araki N, Tokumitsu H, Tezuka T, Yamamoto T, Tokuda M. " "Biochem J. " "372(Pt 2) " 465-471. 2003 "[Original Paper]" "Neuronal mechanism of nociceptin-induced modulation of learning and memory: involvement of N-methyl-D-aspartate receptors. " "Mamiya T, Yamada K, Miyamoto Y, K?nig N, Watanabe Y, Noda Y, Nabeshima T. " "Mol Psychiatry. " "8 " "752-65. " 2003 https://www.ncbi.nlm.nih.gov/pubmed/12888804 "[Original Paper]" "A novel inhibitory effect of D-allose on production of reactive oxygen species from neutrophils. " " Murata A, Sekiya K, Watanabe Y, Yamaguchi F, Hatano N, Izumori K, Tokuda M. " "J Biosci Bioeng " 96 "89-91. " 2003 " https://www.ncbi.nlm.nih.gov/pubmed/16233490" "[Original Paper]" "Clinical relevance of cyclin B1 overexpression in laryngeal squamous cell carcinoma. " "Dong Y, Sui L, Watanabe Y, Sugimoto K, Tokuda M." "Cancer Lett. " 177 "13-9. " 2002 https://www.ncbi.nlm.nih.gov/pubmed/11809526 "[Original Paper]" "Aberrant expression of cyclin A in laryngeal squamous cell carcinoma. " "Dong Y, Sui L, Watanabe Y, Sugimoto K, Tokuda M. " "Anticancer Res. " "22(1A) " "83-9. " 2002 https://www.ncbi.nlm.nih.gov/pubmed/12017338 "[Original Paper]" "Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors. " "Sui L, Dong Y, Ohno M, Watanabe Y, Sugimoto K, Tokuda M." " Int J Oncol. " 21 "315-20. " 2002 https://www.ncbi.nlm.nih.gov/pubmed/12118327 "[Original Paper]" "Survivin expression in laryngeal squamous cell carcinomas and its prognostic implications. " "Dong Y, Sui L, Watanabe Y, Sugimoto K, Tokuda M. " "Anticancer Res. " 22 "2377-83. " 2002 " https://www.ncbi.nlm.nih.gov/pubmed/12174930" "[Original Paper]" "Phosphorylation of neuronal nitric oxide synthase at Ser847 by CaM-KII in the hippocampus of rat brain after transient forebrain ischemia. " "Osuka K, Watanabe Y, Usuda N, Nakazawa A, Fukunaga K, Miyamoto E, Takayasu M, Tokuda M, Yoshida J. " "J Cereb Blood Flow Metab. " 22 "1098-106. " 2002 https://www.ncbi.nlm.nih.gov/pubmed/12218415 "[Original Paper]" "Expression of p57kip2 and its clinical relevance in epithelial ovarian tumors." "Sui L, Dong Y, Ohno M, Watanabe Y, Sugimoto K, Tokuda M. " "Anticancer Res. " "22(6A) " "3191-6. " 2002 https://www.ncbi.nlm.nih.gov/pubmed/12530064 "[Original Paper]" "Dephosphorylation of nNOS at Ser(847) by protein phosphatase 2A." "Komeima K, Watanabe Y. " "FEBS Lett. " 497 "65-6. " 2001 https://www.ncbi.nlm.nih.gov/pubmed/11376664 "[Original Paper]" "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells. " "Komeima K, Hayashi Y, Naito Y, Watanabe Y. " "J Biol Chem. " 275 "28139-43. " 2000 https://www.ncbi.nlm.nih.gov/pubmed/10874031 "[Original Paper]" "Regulation of neuronal nitric-oxide synthase by calmodulin kinases." "Hayashi Y, Nishio M, Naito Y, Yokokura H, Nimura Y, Hidaka H, Watanabe Y." "J Biol Chem." 274 20597-20602. 1999 10.1074/jbc.274.29.20597 http://www.jbc.org/content/274/29/20597.long "[Original Paper]" "Multi-modality assessment of nitric oxide synthase inhibition in focal cerebral ischemia Koketsu N., Suzuki Y., Watanabe Y., Takayasu M., Kano T., Dogan A., Shibuya M., Saito K., and Yoshida J. " "Koketsu N., Suzuki Y., Watanabe Y., Takayasu M., Kano T., Dogan A., Shibuya M., Saito K., and Yoshida J. " "J. Neurovascular Disease " "3 " "243-252 " 1998 "[Original Paper]" "Cloning and expression of a cDNA encoding a new neurocalcin isoform (neurocalcin alpha) from bovine brain. " "Kato M, Watanabe Y, Iino S, Takaoka Y, Kobayashi S, Haga T, Hidaka H. " "Biochem J. " "331 ( Pt 3) " "871-6. " 1998 https://www.ncbi.nlm.nih.gov/pubmed/9560316 "[Original Paper]" "Inducible cyclooxygenase expression in canine basilar artery after experimental subarachnoid hemorrhage. Osuka K, Suzuki Y, Watanabe Y, Takayasu M, Yoshida J. Stroke. 29 1219-22. 1998" "Osuka K, Suzuki Y, Watanabe Y, Takayasu M, Yoshida J. " "Stroke. " "29 " "1219-22. " 1998 " https://www.ncbi.nlm.nih.gov/pubmed/9626297" "[Original Paper]" "Inter-isoformal regulation of nitric oxide synthase through heteromeric dimerization. " "Watanabe Y, Nishio M, Hamaji S, Hidaka H. " "Biochim Biophys Acta. " 1388 "199-208. " 1998 https://www.ncbi.nlm.nih.gov/pubmed/9774731 "[Original Paper]" "HMN-1180, a small molecule inhibitor of neuronal nitric oxide synthase. " "Nishio M, Watanabe Y, Hidaka H. " "J Pharmacol Exp Ther. " 287 "1063-7. " 1998 https://www.ncbi.nlm.nih.gov/pubmed/9864293 "[Original Paper]" "Neuronal nitric oxide synthase-membrane phospholipid interactions. " "Watanabe Y, Nishio M, Hamaji S, Hayashi Y, Hu Y, Hidaka H. " "Arch Biochem Biophys. " 358 "68-73. " "1998 " https://www.ncbi.nlm.nih.gov/pubmed/9750166 "[Original Paper]" "Identification of a specific amino acid cluster in the calmodulin-binding domain of the neuronal nitric oxide synthase. " "Watanabe Y, Hu Y, Hidaka H." "FEBS Lett. " 403 "75-8. " 1997 "[Original Paper]" "Vasodilator effects on canine basilar artery induced by intracisternal interleukin-1 beta. " "Osuka K, Suzuki Y, Watanabe Y, Dogan A, Takayasu M, Shibuya M, Yoshida J." "J Cereb Blood Flow Metab. " "17 " "1337-45. " 1997 https://www.ncbi.nlm.nih.gov/pubmed/9397033 "[Original Paper]" "Isoform-specific activation and structural diversity of calmodulin kinase I. " "Naito Y, Watanabe Y, Yokokura H, Sugita R, Nishio M, Hidaka H." " J Biol Chem. " 272 "32704-8. " 1997 "[Original Paper]" "Activation of calcineurin A subunit phosphatase activity by its calcium-binding B subunit. " "Watanabe Y, Perrino BA, Soderling TR. " "Biochemistry. " 35 "562-6. " 1996 " https://www.ncbi.nlm.nih.gov/pubmed/8555228" "[Original Paper]" "Neuronal nitric oxide synthase specific autophosphorylation in baculovirus/Sf9 insect cell system. " "Watanabe Y, Terashima K, Hidaka H. " "Biochem Biophys Res Commun. " 219 "638-43. " 1996 https://www.ncbi.nlm.nih.gov/pubmed/8605040 "[Original Paper]" "A new and potent calmodulin antagonist, HF-2035, which inhibits vascular relaxation induced by nitric oxide synthase. " "Win NH, Ishikawa T, Saito N, Kato M, Yokokura H, Watanabe Y, Iida Y, Hidaka H." "Eur J Pharmacol. " 299 "119-26. " 1996 https://www.ncbi.nlm.nih.gov/pubmed/8901014 "[Original Paper]" "Isoform-specific intracellular vesicle formation by recombinant annexin XI-A in Sf9 cells. " "Sudo T, Mamiya N, Goto M, Watanabe Y, Hidaka H. " "Biochem Biophys Res Commun. " 223 "706-11. " 1996 https://www.ncbi.nlm.nih.gov/pubmed/8687461 "[Original Paper] " "Identification in the calcineurin A subunit of the domain that binds the regulatory B subunit." "Watanabe Y, Perrino BA, Chang BH, Soderling TR. " "J Biol Chem. " 270 456-60. 1995 "10.1074/jbc.270.1.456 " http://www.jbc.org/content/270/1/456.long "[Original Paper]" "Calvasculin, as a factor affecting the microfilament assemblies in rat fibroblasts transfected by src gene. " "Watanabe Y, Usada N, Minami H, Morita T, Tsugane S, Ishikawa R, Kohama K, Tomida Y, Hidaka H. " "FEBS Lett. " 324 "51-5. " 1993 https://www.ncbi.nlm.nih.gov/pubmed/8504859 "[Original Paper]" "Relaxant effects of various xanthine derivatives. Relationship to cyclic nucleotide phosphodiesterase inhibition. " "Takagi K, Ogawa K, Tanaka H, Satake T, Watanabe Y, Chijiwa T, Hidaka H. " "Adv Second Messenger Phosphoprotein Res " 25 "353-62. " 1992 https://www.ncbi.nlm.nih.gov/pubmed/1313267 "[Original Paper]" "Isolation and characterization of a calcium-binding protein derived from mRNA termed p9Ka, pEL-98, 18A2, or 42A by the newly synthesized vasorelaxant W-66 affinity chromatography. " "Watanabe Y, Kobayashi R, Ishikawa T, Hidaka H. " "Arch Biochem Biophys. " 292 "563-9. " 1992 https://www.ncbi.nlm.nih.gov/pubmed/1731618 "[Original Paper]" "Calvasculin, an encoded protein from mRNA termed pEL-98, 18A2, 42A, or p9Ka, is secreted by smooth muscle cells in culture and exhibits Ca(2+)-dependent binding to 36-kDa microfibril-associated glycoprotein. " "Watanabe Y, Usuda N, Tsugane S, Kobayashi R, Hidaka H." " J Biol Chem. " "267 " "17136-40. " 1992 " https://www.ncbi.nlm.nih.gov/pubmed/1512251" "[Original Paper]" "Specific binding of CAP-50 to calcyclin. " "Minami H, Tokumitsu H, Mizutani A, Watanabe Y, Watanabe M, Hidaka H. " "FEBS Lett. " 305 "217-9. " "1992 " https://www.ncbi.nlm.nih.gov/pubmed/1299619 [Review] "[Trend in the development of new inhibitors of cyclic nucleotide metabolism and their clinical application]. " "Hidaka H, Hagiwara M, Watanabe Y. " "Nihon Rinsho. " 49 "961-7. " 1991 https://www.ncbi.nlm.nih.gov/pubmed/1649350