Yoshimitsu Hashimoto ｜教員紹介 | 薬化学研究室

Profile

Name: Yoshimitsu Hashimoto
Affiliation: Laboratory of Organic Chemistry
Subjects: Basic Organic Chemistry II, Exercise of Organic Chemistry
Organic Chemistry I
Organic Chemistry I, Exercise of Organic Chemistry
Laboratory Practice of Organic Chemistry I
Advanced Organic Chemistry
Official title: Senior Assistant Professor
Degree: Ph.D. (Dr.Sc. in Chemistry)

Academic background

2009 B.Pharm., Showa Pharmaceutical University (Prof. Osamu Tamura)
2011 M.Sc., Chemistry, Tokyo Institute of Technology (Prof. Keisuke Suzuki)
2014 Ph.D., Chemistry, Tokyo Institute of Technology (Prof. Keisuke Suzuki)

Career history

2013   JSPS Research Fellowship for Young Scientists (DC2)
2014   Assistant Professor, Showa Pharmaceutical University
2019 – present Senior Assistant Professor, Showa Pharmaceutical University
September 2021 – August 2022   Visiting Scholar, University of California, Davis (Prof. Dean J. Tantillo)

Licenses and qualifications

Passed - Applied Information Technology Engineer Examination
Hazardous Materials Engineer (Class A)
Pharmacist License in Japan

Honors & Awards

2016 August BCSJ Award (the best paper award of Bull. Chem. Soc. Jpn.)
2024 February Kanto Chemical Award in Synthetic Organic Chemistry, Japan (The Society of Synthetic Organic Chemistry, Japan)

Academic societies

The Chemical Society of Japan (2010 – present)
The Society of Synthetic Organic Chemistry, Japan (2011 – present)
The Pharmaceutical Society of Japan (2015 – present)
The Society of Physical Organic Chemistry, Japan (2022 – present)

Research fields

Organic Chemistry, Synthetic Chemistry, Theoretical Chemistry, Computational Chemistry

Papers

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[Original paper]　Gold-Catalyzed Propargylic Substitution Followed by Cycloisomerization in Ionic Liquid: Environmentally Friendly Synthesis of Polysubstituted Furans from Propargylic Alcohols and 1,3-Dicarbonyl Compounds　Chiaki, H.; Hashimoto, Y.; Morita, N.　Molecules　29　5441　2024　[Related links]
[Original paper]　Hetero Cope-Type Hydroamination of Hetero-Allenes with Oximes Having Olefin Moieties Leading to Nitrones, Causing Intramolecular Cycloaddition　Ide, Y.; Matsuda, N.; Osada, M.; Yamamoto, A.; Tanaka, K. III; Hashimoto, Y.; Morita, N.; Tamura, O.　J. Org. Chem.　89　12973–12981　2024　[Related links]
[Original paper]　Discovery of a Formal Dyotropic Rearrangement during Acid-Mediated Dioxabicyclo[4.2.1]nonanone Formation　Hashimoto, Y.; Kong W.-Y.; Tantillo, D. J.　Org. Lett.　26　5441–5446　2024　[Related links]
[Original paper]　An Efficient Stereoselective Synthesis of cis-2,6-Disubstituted Tetrahydropyrans via Gold-Catalyzed Meyer–Schuster Rearrangement/Hydration/oxa-Michael Addition Sequence　Morita, N.; Yamashita, D.; Hashimoto, Y.; Tamura, O.　Catalysts　14　228　2024　[Related links]
[Original paper]　Intermolecular 1,3-Dipolar Cycloaddition Reaction of N-Carbamoyl Nitrones Generated by N-Selective Carbamoylation of Oximes with Isocyanates.　Yamamoto, A.; Tanaka, K. III; Hashimoto, Y.; Morita, N.; Tamura, O.　Chem. Eur. J.　30　e202303790　2024　[Related links]
[Original paper]　(E)-5-[Bromo(phenyl)methylene]-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole　Morita, N.; Kurami, S.; Ishii, N.; Tanaka, K. III; Hashimoto, Y.; Tamura, O.　Molbank　2024　M1769　2024　[Related links]
[Original paper]　Gold(III)-Catalyzed Propargylic Substitution Reaction Followed by Cycloisomerization for Synthesis of Poly-Substituted Furans from N-Tosylpropargyl Amines with 1,3-Dicarbonyl Compounds　Morita, N.; Uchida, S.; Chiaki, H.; Ishii, N.; Tanikawa, K.; Tanaka, K. III; Hashimoto, Y.; Tamura, O.　Molecules　29　378　2024　[Related links]
[Original paper]　Direct Generation of N-Alkoxycarbonyl Nitrones from Oximes: Intramolecular Cycloaddition of Oximes Having Alkene Moieties　Sagara, H.; Suzuki, Y.; Morita, N.; Ban, S.; Tanaka, K. III; Yamamoto, A.; Hashimoto, Y.; Tamura, O.　Adv. Synth. Cat.　365　3927–3934　2023　[Related links]
[Original paper]　Electrophilic C3?H Alkenylation of 2,6-Dialkoxypyridine Derivatives via Pd(II)/Tl(III) Reaction System　Yamada, T.; Tanaka, K. III; Hashimoto, Y.; Morita, N.; Tamura, O.　Adv. Synth. Cat.　365　3138–3148　2023　[Related links]
[Original paper]　Sustainable Chemical Synthesis of 2,3-Dihydrobenzofurans/1,2,3-Trisubstituted Indanes in Water by Using a Permethylated β-Cyclodextrin-Tagged N-Heterocyclic Carbene–Gold Catalyst　Morita, N.; Chiaki, H.; Tanaka, K. III; Hashimoto, Y.; Tamura, O.; Krause, N.　Synlett　34　1425-1432　2023　[Related links]
[Original paper]　Gold-Catalyzed Formal (3+2) Cycloaddition in an Ionic Liquid: Environmentally Friendly and Stereoselective Synthesis of Polysubstituted Indanes from Benzylic Alcohols and 1-Phenylpropenes　Morita, N.; Chiaki, H.; Ikeda, K.; Tanaka, K. III; Hashimoto, Y.; Tamura, O.　Synlett　34　1068-1074　2023　[Related links]
[Original paper]　(Z)-5-Benzylidene-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole　Morita, N.; Chiaki, H.; Aonuma, S.; Tanaka, K. III; Hashimoto, Y.; Tamura, O.　Molbank　2023　M1600　2023　[Related links]
[Original paper]　Synthesis of N-Aryl Isoxazolidines by Photo-Promoted N-Selective Arylation of Oximes and Cyclization Using Hypervalent Iodine Reagents and Copper Catalyst.　Tanaka, K. III; Yoshida, M.; Yamamoto, A.; Hashimoto, Y.; Morita, N.; Tamura, O.　Adv. Synth. Cat.　365　1419-1424　2023　[Related links]
[Original paper]　Directing-Group-Free Palladium-Catalyzed C–H Arylation of Aldoxime Using Oxime’s Umpolung Properties　Tanaka, K. III; Hashimoto, Y.; Morita, N.; Tamura, O.　Org. Lett.　24　8954-8958　2022　[Related links]
[Original paper]　Mechanism and Periselectivity in Cycloaddition Reactions of Benzyne with Dienes　Hashimoto, Y; Tantillo, D. J.　J. Org. Chem.　87　12954-12962　2022　[Related links]
[Original paper]　Cationic palladium(ii)-catalyzed synthesis of substituted pyridines from α,β-unsaturated oxime ethers　Yamada, T.; Hashimoto, Y.; Tanaka, K. III; Morita, N.; Tamura, O.　RSC Adv.　12　21548-21557　2022　[Related links]
[Original paper]　Electrophilic Epoxidation of α,β-Unsaturated Oximes with Dioxiranes and Ring Opening of the Epoxides　Furugoori, M.; Yoshida, K.; Hashimoto, Y.; Morita, N.; Tanaka, K. III; Tamura, O.　Chem. Pharm. Bull.　69　1010-1016　2021　[Related links]
[Original paper]　Gold-Catalyzed Formal [3+2] Cycloaddition of p-Quinones and 1-Phenylpropenes in Ionic Liquid: Environmentally Friendly and Stereoselective Synthesis of Benzofuran Neolignans　Morita, N.; Ikeda, K.; Chiaki, H.; Araki, R.; Tanaka, K. III; Hashimoto Y.; Tamura, O.　Heterocycles　103　714-722　2021　[Related links]
[Original paper]　Palladium(II)-Catalyzed Substituted Pyridine Synthesis from α,β-Unsaturated Oxime Ethers via a C–H Alkenylation/Aza-6π-Electrocyclization Approach　Yamada, T.; Hashimoto, Y.; Tanaka, K. III; Morita, N.; Tamura, O.　Org. Lett.　23　1659-1663　2021　[Related links]
[Original paper]　Synthesis and Formation Mechanism of a Compound with an Unprecedented Skeleton: Dodecahydro-4,10:5,9-diepoxydipyrrolo[3,4-b:3′,4′-f][1,5]diazocine　Shinoda, M.; Morita, N.; Tanaka, K. III; Hashimoto, Y.; Ban, S.; Tamura, O.　Chem. Pharm. Bull.　68　1238-1243　2020　[Related links]
[Original paper]　Thioether Ligand-Enabled Cationic Palladium(II)-Catalyzed Electrophilic C–H Arylation of α,β-Unsaturated Oxime Ethers　Yamada, T.; Hashimoto, Y.; Tanaka, K. III; Morita, N.; Tamura, O.　J. Org. Chem.　85　12315-12328　2020　[Related links]
[Original paper]　Intramolecular Activation of Imidate with Cationic Gold(I) Catalyst: a New Benzylation Reaction of Alcohols　Ban, S.; Endo, T.; Matsui, R.; Morita, N.; Hashimoto, Y.; Tanaka, K. III; Tamura, O.　Tetrahedron Lett.　61　152233-152235　2020　[Related links]
[Original paper]　O-Alkyl S-(Pyridin-2-yl)carbonothiolates: Operationally Simple and Highly Nitrogen-Selective Reagents for Alkoxy Carbonylation of Amino Groups　Suzuki, T.; Tanaka, K. III; Hashimoto, Y.; Morita, N.; Tamura, O.　Synlett　31　899-902　2020　[Related links]
[Original paper]　Chelation-Based Homologation by Reaction of Organometallic Reagents with O-Alkyl S-Pyridin-2-yl Thiocarbonates: Synthesis of Esters from Grignard Reagents　Usami, S.; Suzuki, T.; Mano, K.; Tanaka, K. III; Hashimoto, Y.; Morita, N.; Tamura, O.　Synlett　30　1561-1564　2019　[Related links]
[Original paper]　Inverse-Electron-Demand oxa-Diels–Alder Reactions of α-Keto-β,γ-unsaturated Esters and α,β-Unsaturated Hydrazones　Hashimoto, Y.; Ikeda, T.; Ida, A.; Morita, N.; Tamura, O.　Org. Lett.　21　4245-4249　2019　[Related links]
[Original paper]　Efficient One-Pot Synthesis of Substituted Oxazoles from 3-Trimethylsilylpropargylic Alcohols and Amides by Gold-Catalyzed Substitution Followed by Cycloisomerization　Morita, N.; Sano, A.; Sone, A.; Aonuma, S.; Matsunaga, A.; Hashimoto, Y.; Tamura, O.　Heterocycles　97　719-728　2018　[Related links]
[Original paper]　Inverse-electron-demand Diels–Alder reactions of α,β-unsaturated hydrazones with 3-methoxycarbonyl α-pyrones　Hashimoto, Y.; Abe, R.; Morita, N.; Tamura, O.　Org. Biomol. Chem.　16　8913-8916　2018　[Related links]
[Original paper]　Total Synthesis of Neodysiherbaine A via 1,3-Dipolar Cycloaddition of a Chiral Nitrone Template　Hirai, T.; Shibata, K.; Niwano, Y.; Shiozaki, M.; Hashimoto, Y.; Morita, N.; Ban, S.; Tamura, O.　Org. Lett.　19　6320-6323　2017　[Related links]
[Original paper]　First Total Syntheses of Tetracenomycins?C and X　Sato, S.; Sakata, K.; Hashimoto, Y.; Takikawa, H.; Suzuki, K.　Angew. Chem. Int. Ed.　56　12608-12613　2017　[Related links]
[Original paper]　Gold(III)-Catalyzed Synthesis of 2,3,4-Trisubstituted Dihydropyrans from Propargylic Alcohols with 1,3-Dicarbonyl Compounds　Morita, N.; Oguro, K.; Takahashi, S.; Kawahara, M.; Ban, S.; Hashimoto, Y.; Tamura, O.　Heterocycles　95　172-180　2017　[Related links]
[Original paper]　Thiyl radical-mediated cyclization of ω-alkynyl O-tert-butyldiphenylsilyloximes　Shibata, N.; Tsuchiya, T.; Hashimoto, Y.; Morita, N.; Ban, S.; Tamura, O.　Org. Biomol. Chem.　15　3025-3034　2017　[Related links]
[Original paper]　Utilization of electron-donating α,β-unsaturated oximes: regioselective inverse 1,3-dipolar cycloaddition of nitrones　Hashimoto, Y.; Ishiwata, H.; Tachikawa, S.; Ban, S.; Morita, N.; Tamura, O.　Chem. Commun.　53　2685-2688　2017　[Related links]
[Original paper]　Gold-catalyzed dehydrative Friedel–Crafts reaction and Nazarov cyclization sequence: an efficient synthesis of 1,3-diarylindenes from propargylic alcohols　Morita, N.; Miyamoto, M.; Yoda, A.; Yamamoto, M.; Ban, S.; Hashimoto, Y.; Tamura, O.　Tetrahedron Lett.　57　4460-4463　2016　
[Original paper]　Gold-Catalyzed Dimeric Cyclization of Isoeugenol and Related 1-Phenylpropenes in Ionic Liquid: Environmentally Friendly and Stereoselective Synthesis of 1,2,3-Trisubstituted 2,3-Dihydro-1H-indenes　Morita, N.; Mashiko, R.; Hakuta, D.; Eguchi, D.; Ban, S.; Hashimoto, Y.; Okamoto, I.; Tamura, O.　Synthesis　48　1927-1933　2016　
[Original paper]　Gold-Catalyzed Synthesis of 2-Substituted Azepanes: Strategic Use of Soft Gold(I) and Hard Gold(III) Catalysts　Morita, N.; Saito, Y.; Muraji, A.; Ban, S.; Hashimoto, Y.; Okamoto, I.; Tamura, O.　Synlett　27　1936-1940　2016　
[Original paper]　Pleospdione, A Tricyclic Natural Product with Dense Oxygenation at the A Ring: Total Synthesis and Incongruity of the Originally Assigned Structure and Its C3-Epimer　Takikawa, H.; Ishikawa, Y.; Yoshinaga, Y.; Hashimoto, Y.; Kusumi, T.; Suzuki, K.　Bull. Chem. Soc. Jpn.　89　941-954　2016　
[Original paper]　BF₃-Mediated cis-Selective Cycloaddition of O-Silyloxime with Alkenes　Morita, N.; Kono, R.; Fukui, K.; Miyazawa, A.; Masu, H.; Azumaya, I.; Ban, S.; Hashimoto, Y.; Okamoto, I.; Tamura, O.　J. Org. Chem.　80　4797-4802　2015　
[Original paper]　Gold(I)/(III)-Catalyzed Synthesis of Cyclic Ethers; Valency-Controlled Cyclization Modes　Morita, N.; Yasuda, A.; Shibata, M.; Ban, S.; Hashimoto, Y.; Okamoto, I.; Tamura, O.　Org. Lett.　17　2668-2671　2015　
[Original paper]　Gold(I)/(III)-Catalyzed Synthesis of 2-Substituted Piperidines; Valency-Controlled Cyclization Modes　Morita, N.; Tsunokake, T.;Narikiyo, Y.; Harada, M.; Tachibana, T.; Saito, Y.; Ban, S.; Hashimoto, Y.; Okamoto, I.; Tamura, O.　Tetrahedron Lett.　56　6269-6272　2015　
[Original paper]　Isoxazole Platform for Polyketide Assembly: Cycloaddition of Stable Benzonitrile Oxides to Stable ortho-Quinone Monoacetals and Dehydrogenation　Takikawa, H.; Hashimoto, Y.; Suzuki, K.　Chem. Lett.　43　1607-1609　2014　
[Original paper]　Synthesis of isoxazoles en route to semi-aromatized polyketides: dehydrogenation of benzonitrile oxide–para-quinone acetal cycloadducts　Hashimoto, Y.; Takada, A.; Takikawa, H.; Suzuki, K.　Org. Biomol. Chem.　10　6003-6009　2012　[Related links]
[Original paper]　Total Synthesis and Absolute Stereochemistry of Seragakinone A　Takada, A.; Hashimoto, Y.; Takikawa, H.; Hikita, K.; Suzuki, K.　Angew. Chem. Int. Ed.　50　2297-2301　2011　[Related links]

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