??.z%R ?0?0?0?0 W?? ?? T ?]?S ?0?0?0 ?QHrt^ DOI URL "[Original paper]" "Ktedonoketone and 2'-oxosattabacin, benzenoid metabolites from a thermophilic bacterium?<i>Thermosporothrix hazakensis</i>?in the phylum?<i>Chloroflexi</i>" "Igarashi Y, Yamamoto K, Ueno C, Yamada N, Saito K, Takahashi K, Enomoto M, Kuwahara S, Oikawa T, <b><u>Tashiro E</u></b>, Imoto M, Xiaohnyao Y, Zhou T, Harunari E, Oku?N." "J Antibiot (Tokoyo)" 72 653 2019 10.1038/s41429-019-0195-7 [Review] "Screening and identification of inhibitors of endoplasmic reticulum stress-induced activation of the IRE1&alpha;-XBP1 branch" "<b><u>Tashiro E</u></b>" "J Antibiot (Tokoyo)" 72 899 2019 10.1038/s41429-019-0219-3 "[Original paper]" "14-3-3&epsilon;a directs the pulsatile transport of basal factors towards the apical domain for lumen growth in tubulogenesis" "Mizotani Y, Suzuki M, Hotta K, Watanabe H, Shiba K, Inaba K, <b><u>Tashiro E</u></b>, Oka K, Imoto M." PNAS 115 E8873 2018 10.1073/pnas.1808756115 "[Original paper]" "Metacycloprodigiosin induced cell death selectively in &beta;-catenin-mutated tumor cells" "Ikeda H, Shikata Y, Watanapokasin R, <b><u>Tashiro E</u></b>, Imoto M" "J Antibiot (Tokoyo)" 70 109 2017 10.1038/ja.2016.75 "[Original paper]" "Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor" "Shikata Y, Yoshimaru T, Komatsu M, Katoh H, Sato R, Kanagaki S, Okazaki Y, Toyokuni S, <b><u>Tashiro E</u></b>, Ishikawa S, Katagiri T, Imoto M" "Cancer Sci" 108 785 2017 10.1111/cas.13175 "[Original paper]" "Nonthmicin, a Polyether Polyketide Bearing a Halogen-Modified Tetronate with Neuroprotective and Antiinvasive Activity from Actinomadura sp." "Igarashi Y, Natsuoka N, In Y, Kataura T, <b><u>Tashiro E</u></b>, Saiki I, Sudoh Y, Duangmal K, Thamchaipenet A" "Org Lett" 19 1406 2017 10.1021/acs.orglett.7b00318 [Review] "Chemistry and biology of the compounds that modulate cell migration" "<b><u>Tashiro E</u></b> and Imoto M" "J Ind Microbiol Biotechnol" 43 213 2016 10.1007/s10295-015-1654-1 "[Original paper]" "Involvement of the MEK/ERK pathway in EGF-induced E-cadherin down-regulation" "<b><u>Tashiro E</u></b>, Henmi S, Odake H, Ino S, Imoto M" "Biochem Biophys Res Commun" 477 801 2016 10.1016/j.bbrc.2016.06.138 "[Original paper]" "SMK-17, a MEK1/2-specific inhibitor, selectively induces apoptosis in &beta;-catenin-mutated tumors" "Kiga M, Nakayama A, Shikata Y, Sasazawa Y, Murakami R, Nakanishi T, <b><u>Tashiro E</u></b>, and Imoto M" "Sci Rep" 5 8155 2015 10.1038/srep08155 "[Original paper]" "Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid" "Krajamg A, Imoto M, <b><u>Tashiro E</u></b>, Fujimaki T, Shinjo S, and Watanapokasin R" "BMC Complement Altem Med" 15 26 2015 10.1186/s12906-015-0544-4 "[Original paper]" "Evaluation of drug toxicity profiles based on the phenotypes of ascidian Ciona intestinalis" "Mizotani Y, Itoh S, Hotta K, <b><u>Tashiro E</u></b>, Oka K, and Imoto M" "Biochem Biophys Res Commun" 463 656 2015 10.1016/j.bbrc.2015.05.119 [Review] "Chemical biology of compounds obtained from screening using disease models" "<b><u>Tashiro E</u></b> and Imoto M" "Arch Pharm Res" 38 1651 2015 10.1007/s12272-015-0633-4 "[Original paper]" "5-lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor-induced cell migration through Tiam1 upregulation and Rac1 activation" "Magi S, Takemoto Y, Kobayashi H, Kasamatsu M, Akita T, Tanaka A, Takano K, <b><u>Tashiro E</u></b>, Igarashi Y, and Imoto M" "Cancer Sci" 105 290 2014 10.1111/cas.12340 "[Original paper]" "Chemical genomic-based pathway analyses for epidermal growth factor-mediated signaling in migrating cancer cells" "Magi S, Saeki Y, Kasamatsu M, <b><u>Tashiro E</u></b>, and Imoto M" "PLoS One" 9 e96776 2014 10.1371/journal.pone.0096776 "[Original paper]" "Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson s disease" "Fujimaki T, Saiki S, <b><u>Tashiro E</u></b>, Yamada D, Kitagawa M, Hattori N, and Imoto M" "PLoS One" 9 e100395 2014 10.1371/journal.pone.0100395 "[Original paper]" "Xanthohumol suppresses oestrogen-signaling in breast cancer through the inhibition of BIG3-PHB2 interactions" "Yoshimaru T, Komatsu M, <b><u>Tashiro E</u></b>, Imoto M, Osada H, Miyoshi Y, Honda J, Sasa M, and Katagiri T" "Sci Rep" 4 7355 2014 10.1038/srep07355 "[Original paper]" "Boronic Acid Inhibitors of Acyl Protein Thioesterase 1 and 2" "Zimmermann TJ, Burger M, <b><u>Tashiro E</u></b>, Kondoh Y, Martinez NE, Gormer K, Rosin-Steiner S, Shimizu T, Ozaki S, Mikoshiba K, Watanabe N, Hall D, Vetter IR, Osada H, Hedberg C and Waldmann H" Chembiochem 14 115 2013 10.1002/cbic.201200571 "[Original paper]" "Novel derivatives of aclacinomycin A block cancer cell migration through inhibition of farnesyl transferase" "Magi S, Shitara T, Takemoto Y, Sawada M, Kitagawa M, <b><u>Tashiro E</u></b>, Takahashi Y and Imoto M" "J Antibiot (Tokoyo)" 66 165 2013 10.1038/ja.2012.108 "[Original paper]" "Comparative Analysis of the UPR-Target Genes Expression Patterns induced by UPR-Inducing Compounds" "Shinjo S, Mizotani Y, <b><u>Tashiro E</u></b> and Imoto M" "Biosci Biotechnol Biochem" 77 729 2013 "[Original paper]" "Establishment of a new detection system for the dimerization of IRE1&alpha; using a BiFC assay" "Shinjo S, <b><u>Tashiro E</u></b> and Imoto M" "Biosci Biotechnol Biochem" 77 1333 2013 "[Original paper]" "Antitumor effects of novel highly hydrophilic and non-ATP-competitive MEK1/2 inhibitor, SMK-17" "Kiga M, Tanzawa F, Iwasaki S, Inaba F, Fujiwara K, Iwadare H, Echigo T, Nakamura Y, Shibata T, Suzuki K, Yasumatsu I, Nakayama A, Sasazawa Y, <b><u>Tashiro E</u></b>, Imoto M and Kurakata S" "Anticancer Drugs" 23 119 2012 10.1097/CAD.0b013e32834c6a33 [Review] "Target identification of bioactive compounds" "<b><u>Tashiro E</u></b> and Imoto M" "Bioorg Med Chem" 20 1910 2012 10.1016/j.bmc.2011.10.081 "[Original paper]" "Napyradiomycin A1, an inhibitor of mitochondrial complex I and II" "Yamamoto K, <b><u>Tashiro E</u></b>, Motohashi K, Seto H and Imoto M" "J Antibiot (Tokoyo)" 65 211 2012 10.1038/ja.2011.138 "[Original paper]" "Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein" "Sasazawa Y, Kanagaki S, <b><u>Tashiro E</u></b>, Nogawa T, Muroi M, Kondoh Y, Osada H and Imoto M" "ACS Chem Biol" 7 892 2012 10.1021/cb200492h "[Original paper]" "Inostamycin enhanced TRAIL-induced apoptosis through DR5 up-regulation on the cell surface" "Yamamoto K, Makino M, Watanapokasin R, <b><u>Tashiro E</u></b> and Imoto M" "J Antibiot (Tokoyo)" 65 295 2012 10.1038/ja.2012.21 "[Original paper]" "Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a Potent Inhibitor of ER stress-induced XBP1 mRNA Splicing" "Ri M*, <b><u>Tashiro E</u></b>*, Oikawa D, Shinjo S, Tokuda M. Yokouchi Y, Narita T, Masaki A, Ito A, Ding J, Kusumoto S, Ishida T, Komatsu H, Shiotsu Y, Ueda R, Iwawaki T, Imoto M and Iida S" "Blood Cancer J" 2 e79 2012 10.1038/bcj.2012.26 "[Original paper]" "A chemical genetic study identifying diversity in cell migration signaling in cancer cells" "Magi S, <b><u>Tashiro E</u></b> and Imoto M" "Sci Rep" 2 823 2012 10.1038/srep00823 "[Original paper]" "Synthesis and anti-migrative evaluation of moverastin derivatives" "Sawada M, Kubo S, Matsumura K, Takemoto Y, Kobayashi H, <b><u>Tashiro E</u></b>, Kitahara T, Watanabe H and Imoto M" "Bioorg Med Chem Lett" 21 1385 2011 10.1016/j.bmcl.2011.01.028 "[Original paper]" "A new, convenient cell-based screening method for small-molecule glycolytic inhibitors" "Kitagawa M, Misawa M, Ogawa S, <b><u>Tashiro E</u></b> and Imoto M" "Biosci Biotechnol Biochem" 75 367 2011 "[Original paper]" "Quinotrierixin inhibited ER stress-induced XBP1 mRNA splicing through inhibition of protein synthesis" "Yamamoto K, <b><u>Tashiro E</u></b> and Imoto M" "Biosci Biotechnol Biochem" 75 284 2011 "[Original paper]" "Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokines" "Yamada Y, <b><u>Tashiro E</u></b>, Taketani S, Imoto M and Kataoka T" "J Antibiot (Tokoyo)" 64 361 2011 10.1038/ja.2011.23 "[Original paper]" "Generation of  Unnatural Natural Product library and identification of a small molecule inhibitor of XIAP" "Kawamura T, Matsubara K, Otaka H, <b><u>Tashiro E</u></b>, Shindo K, Yanagita RC, Irie K and Imoto M" "Bioorg Med Chem" 19 4377 2011 10.1016/j.bmc.2011.05.009 "[Original paper]" "Involvement of 14-3-3 proteins in the second EGF-induced wave of Rac1 activation in the process of cell migration" "Kobayashi H, Ogura Y, Sawada M, Nakayama R, Takano K, Minato Y, Takemoto Y, <b><u>Tashiro E</u></b>, Watanabe H and Imoto M" "J Biol Chem" 286 39259 2011 10.1074/jbc.M111.255489 "[Original paper]" "Isolation and structure elucidation of a novel androgen antagonist, arabilin, produced by Streptomyces sp. MK756-CF1" "Kawamura T, Fujimaki T, Hamanaka N, Torii K, Kobayashi H, Takahashi Y, Igarashi M, Kinoshita N, Nishimura Y, <b><u>Tashiro E</u></b> and Imoto M" "J Antibiot (Tokoyo)" 63 601 2010 10.1038/ja.2010.98 "[Original paper]" "Metabolomic identification of the target of the filopodia protrusion inhibitor glucopiericidin A" "Kitagawa M, Ikeda S, <b><u>Tashiro E</u></b>, Soga T and Imoto M" "Chem Biol" 17 989 2010 10.1016/j.chembiol.2010.06.017 "[Original paper]" "Transcriptional regulation of human fibroblast growth factor receptor 1 by E2F-1" "Kanai M, <b><u>Tashiro E</u></b>, Maruki H, Minato Y and Imoto M" Gene 438 49 2009 10.1016/j.gene.2009.03.004 "[Original paper]" "V-ATPase Inhibitors Overcome Bcl-xL-mediated Chemoresistance through Restoration of a Caspase-independent Apoptotic Pathway" "Sasazawa Y, Futamura Y, <b><u>Tashiro E</u></b> and Imoto M" "Cancer Sci" 100 1460 2009 10.1111/j.1349-7006.2009.01194.x "[Original paper]" "Oligomycin induced the proteasomal degradation of cyclin D1" "Kanai M, Iba S, Okada R, <b><u>Tashiro E</u></b> and Imoto M" "J Antibiot (Tokoyo)" 62 425 2009 10.1038/ja.2009.47 "[Original paper]" "Discovery of Incednine as a Potent Modulator of the Anti-apoptotic Function of Bcl-xL from Microbial Origin" "Futamura Y, Sawa R, Umezawa Y, Igarashi M, Nakamura H, Hasegawa K, Yamasaki M, <b><u>Tashiro E</u></b>, Takahashi Y, Akamatsu Y and Imoto M" "J Am Chem Soc" 130 1822 2008 10.1021/ja710124p "[Original paper]" "Identification and characterization of mouse type II platelet-derived growth factor receptor a transcript" "Minato Y*, Nihei Y*, Kodama Y, <b><u>Tashiro E</u></b>, Kanai M and Imoto M" "Biosci Biotechnol Biochem" 72 759 2008 "[Original paper]" "SAR study of a Novel Triene-ansamycin Group Compound, Quinotrierixin, and Related Compounds, as Inhibitors of ER Stress-induced XBP1 Activation. I. Taxonomy, Fermentation, Isolation, and Biological activities and SAR study" "Kawamura T, <b><u>Tashiro E</u></b>, Yamamoto K, Shindo K and Imoto M" "J Antibiot (Tokoyo)" 61 303 2008 10.1038/ja.2008.43 "[Original paper]" "SAR study of a Novel Triene-ansamycin Group Compound, Quinotrierixin, and Related Compounds, as Inhibitors of ER Stress-induced XBP1 Activation. II. Structure Elucidation" "Kawamura T, <b><u>Tashiro E</u></b>, Shindo K and Imoto M" "J Antibiot (Tokoyo)" 61 312 2008 10.1038/ja.2008.44 "[Original paper]" "Involvement of PP2A nuclear accumulation and subsequent inactivation of AP-1 in leptomycin B-inhibited cyclin D1 expression" "Tsuchiya A, <b><u>Tashiro E</u></b>, Yoshida M and Imoto M" Oncogene 26 1522 2007 [Review] "Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression" "<b><u>Tashiro E</u></b>, Tsuchiya A and Imoto M" "Cancer Sci" 98 629 2007 "[Original paper]" "Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA" "Kaida D, Motoyoshi H, <b><u>Tashiro E</u></b>, Nojima T, Hagiwara M, Ishigami K, Watanabe H, Kitahara T, Yoshida T, Nakajima H, Tani T, Horinouchi S and Yoshida M" "Nat Chem Biol" 3 576 2007 "[Original paper]" "Transcriptional regulation of a new transcript variant of human platelet-derived growth factor receptor &alpha; by E2F-1" "Minato Y, <b><u>Tashiro E</u></b>, Kanai M, Nihei Y, Kodama Y and Imoto M" Gene 403 89 2007 "[Original paper]" "Trierixin, a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp. I. Taxonomy, Fermentation, Isolation, and Biological activities" "<b><u>Tashiro E</u></b>, Hironiwa N, Kitagawa M, Futamura Y, Suzuki S, Nishio M and Imoto M" "J Antibiot (Tokoyo)" 60 547 2007 "[Original paper]" "Trierixin, a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp. II. Structure Elucidation" "Futamura Y, <b><u>Tashiro E</u></b>, Hironiwa N, Kohno J, Nishio M, Shindo K and Imoto M" "J Antibiot (Tokoyo)" 60 582 2007 "[Original paper]" "Suppression of multidrug resistance by migrastatin" "Takemoto Y, <b><u>Tashiro E</u></b> and Imoto M" "J Antibiot (Tokoyo)" 59 435 2006 "[Original paper]" "GSK-3beta directly phosphorylates and activates MARK2/PAR-1" "Kosuga S*, <b><u>Tashiro E</u></b>*, Kajioka T, Ueki M, Shimizu Y and Imoto M" "J Biol Chem" 280 42715 2005 "[Original paper]" "Chemistry and biology of moverastins, inhibitors of cancer cell migration, produced by Aspergillus" "Takemoto Y, Watanabe H, Uchida K, Matsumura K, Nakae K, <b><u>Tashiro E</u></b>, Shindo K, Kitahara T and Imoto M" "Chem Biol" 12 1337 2005 "[Original paper]" "Involvement of nuclear accumulation of heat shock protein 27 in leptomycin B-induced apoptosis in HeLa cells" "Tsuchiya A, <b><u>Tashiro E</u></b>, Yoshida M and Imoto M" "J Antibiot (Tokoyo)" 58 810 2005 "[Original paper]" "Overexpression of cyclin D1 contributes to malignancy by up-regulation of FGF receptor 1 via the pRB/E2F pathway" "<b><u>Tashiro E</u></b>, Maruki H, Minato Y, Doki Y, Weinstein IB and Imoto M" "Cancer Res" 63 424 2003 "[Original paper]" "Regulation of FGF receptor-2 expression by transcription factor E2F-1" "<b><u>Tashiro E</u></b>, Minato Y, Maruki H, Asagiri M and Imoto M" Oncogene 22 5630 2003 "[Original paper]" "Herbimycin A induces G1 arrest through accumulation of p27Kip1 in cyclin D1-overexpressing fibroblasts" "Endo N, <b><u>Tashiro E</u></b>, Umezawa K, Kawada M, Uehara Y, Doki Y, Wesinstein IB and Imoto M" "Biochem Biophys Res Commun" 267 54 2000 "[Original paper]" "Inhibition of cyclin D1 expression and induction of apoptosis by Inostamycin in small cell lung carcinoma cells" "Imoto M, Tanabe K, Simizu S, <b><u>Tashiro E</u></b>, Takada M and Umezawa K" "Jpn J Cancer Res" 89 315 1998 "[Original paper]" "Caspase-3 activation is not responsible for Vinblastine-induced Bcl-2 phosphorylation and G2/M arrest in small cell lung carcinoma Ms-1 cells" "<b><u>Tashiro E</u></b>, Simizu S, Takada M, Umezawa K and Imoto M" "Jpn J Cancer Res" 89 940 1998 "[Original paper]" "Potentiation of Paclitaxel cytotoxicity by Inostamycin in human small cell lung carcinoma, Ms-1 cells" "Simizu S, Tanabe K, <b><u>Tashiro E</u></b>, Takada M, Umezawa K and Imoto M" "Jpn J Cancer Res" 89 970 1998