生化学研究室

昭和薬科大学研究室一覧

昭和薬科大学研究室一覧

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Susumu ItohProfessor / Ph.D.last update : 2024.04.20

Japanese

Profile

Name
Susumu Itoh
Affiliation
Laboratory of Biochemistry
Subjects
　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
Official title
Professor
Degree
Ph.D.

Academic background

1990  Ph.D. (Pharmaceutical Sciences), Osaka University, Osaka, Japan
1987  M.S. (Pharmaceutical Sciences), Osaka University, Osaka, Japan
1985  B.S. (Pharmaceutical Sciences), Osaka University, Osaka, Japan
1981  Graduated from Nishinomiya-Higashi High School, Nishinomiya, Japan
 

Career history

2010- Professor, Laboratory of Biochemistry, Showa Pharmaceutical University, Japan
2004-2010 Associate Professor, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
2002-2004 Associate Professor, Institute of Basic Medical Sciences, University of Tsukuba, Japan
1999-2002 Postdoctoral Fellow, The Netherlands Cancer Institute, The Netherlands
1996-1999 Postdoctoral Fellow, Ludwig Institute for Cancer Research, Uppsala Branch, Sweden
1994-1996 Research Associate, Faculty of Pharmaceutical Sciences, Osaka University, Japan
1990-1994 Research Associate, Faculty of Pharmaceutical Sciences, Hokkaido University, Japan
 

Research fields

TGF-β signal
angiogenesis
oncogene and tumor suppressor gene
epithelial mechencymal transition
tumorigenisity

 

Books

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  • 薬学のための分子生物学　編集［金田　典雄、伊東　進］　伊東　進、伊東　史子　第７章　遺伝子工学　256-276　廣川書店　2014　
  • がん増殖と悪性化の分子機構　編集［宮澤　恵二、伊東　進］　伊東　進　２章　増殖抑制シグナルの破綻　27-41　化学同人　2012　
  • がん増殖と悪性化の分子機構　編集［宮澤　恵二、伊東　進］　宮澤　恵二、伊東　進　序章　がん研究の進歩　1-9　化学同人　2012　
  • 別冊医学のあゆみ　伊東　進　TGF-βファミリーシグナル抑制機構　13-19　医歯薬出版　2011　
  • Transforming growth factor-β in cancer therapy (ed. Jakowlew SB)　Itoh S., Suzuki H., Itoh F., Miyazono K., Kato M.　Negative regulation of the TGF-β family signal pathway by inhibitory Smads and their involvement in cancer and fibrosis.　649-662　Humana Press　2008　
  • TGF-β and related cytokines in inflammation ( eds. Breit SN and Wahl S)　Heldin C.-H., Moustakas A., Souchelnytskyi S., Itoh S., ten Dijke P.　Signal transduction mechanisms for members of the TGF-β superfamily.　11-40　Birkhäuser Verlag AG　2001　
  • Proc. of ROC-Japan Symp. on Suncus Murinus: New experimental animal, its specificity and usefulness (ed. by C.-Y. Chen)　Kamatakizawa T., Nakura H., Itoh S.　Characters of house musk shrew (Suncus murinus): focusing on enzymes involved in drug metabolism.　89-96　　1994　

Papers

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  • 原著論文　Involvement of mitogen- and stress-activated protein kinase 1 in BMP-6–induced chondrocyte differentiation　Nakano N, Tashiro E, Shimada T, Ebisawa M, Kojima S, Ayabe K, Yamamoto Y, Maeda, S, Itoh F, Itoh S　J. Biol. Chem.　300　107806　2024　
  • 原著論文　Reduced lung metastasis in endothelial cell-specific TGF-β type II receptor-deficient mice with decreased CD44 expression　Kako Hanada, Yuki Saito, Takahiro Takagi, Mitsuki Go, Yota Nakano, Toshihiko Inagawa, Hideyo Hirai, Marcus Fruttiger, Susumu Itoh, Fumiko Itoh　iSicence　27　111502　2024　[Related links]
  • 原著論文　Hybrid molecule between platanic acid and LCL-161 as a yes-associated protein (YAP) degrader.　Nakano N, Fukuda K, Tashiro E, Ishikawa H, Nagano W, Kawamoto R, Mori A, Watanabe M, Yamazaki R, Nakane T, Naito M, Okamoto I, Itoh S.　J. Biochem.　171　631-640　2022　
  • 原著論文　Involvement of miR-3180-3p and miR-4632-5p in palmitic acid-induced insulin resistance.　Tashiro E, Nagasawa Y, Itoh S, Imoto M.　Mol. Cell. Endocrinol.　534　111371　2021　
  • 原著論文　Endothelial-specific depletion of TGF-β signaling affects lymphatic function.　Fukasawa K, Hanada K, Ichikawa K, Hirashima M, Takagi T, Itoh S, Watabe T, Itoh F.　 Inflamm. Regeneration　41　35　2021　
  • 原著論文　Narciclasine is a novel YAP inhibitor that disturbs interaction between YAP and TEAD4　Kawamot R, Nakano N, Ishikawa H, Tashiro E, Nagano W, Sano K, Irie M, Ikuta M, Kishi F, Nakane T, Naito M, Itoh S　BBA Advances　1　100008　2021　[Related links]
  • 原著論文　Environmental and soil characteristics in Ephedra habitats of Uzbekistan　Minami M, Taichi F, Honda Y, Ueno K, Shinozaki J, Itoh S, Takano A, Berdiyar J, Ivanovich Maltsev I, Nakane T　J Nat Med　75　246-258　2021　
  • 原著論文　Physical and chemical characteristics of soils in Ephedra gerardiana and E. pachyclada habitats of Kali Gandaki Valley in Central Nepal.　Minami M, Mori T, Honda Y, Ueno K, Murakami T, Ajioka Y, Atsumi T, Joshi KJ, Yadav PM, Kandel DR, Nakano M, Shinozaki J, Itoh S, Nakane T, Takano A.　 J. Nat. Med.　74　825-833　2020　
  • 原著論文　Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity.　Nakano N, Sakata N, Katsu Y, Nochise D, Sato E, Takahashi Y, Yamaguchi S, Haga Y, Ikeno S, Motizuki M, Sano K, Yamasaki K, Miyazawa K, Itoh S. 　J. Biol Chem.　295　9033–9051　2020　[Related links]
  • 原著論文　PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-β (TGF-β) signaling.　Ikeno S, Nakano N, Sano K, Minowa T, Sato W, Akatsu R, Sakata N, Hanagata N, Fujii M, Itoh F, Itoh S.　J. Biol. Chem.　294　4966-4980　2019　[Related links]
  • 総説　TMEPAI family: involvement in regulation of multiple signaling pathways　Itoh S, Ioth F　Journal of Biochemistry　164　195-204　2018　[Related links]
  • 原著論文　TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α　Hamidi A, Song J, Thakur N, Itoh S, Marcusson A, Bergh A, Heldin C-H, Landstr?m M　Sci. Signal.　10　eaal4186　2017　[Related links]
  • 原著論文　TMED10 interferes with TGF-β signaling by disrupting TGF-β receptor complex formation　Nakano N, Tsuchiya Y, Kako K, Umezaki K, Sano K, Ikeno S, Otsuka E, Shigeta M, Nakagawa A, Sakata N, Itoh F, Nakano Y, Iemura S, van Dinther M, Natsume T, ten Dijke P, Itoh S　J. Biol. Chem.　292　4099-4112　2017　
  • [Original paper]　Regulation of the TMEPAI promoter by TCF7L2: the C-terminal tail of TCF7L2 is essential to activate the TMEPAI gene.　Nakano N, Kato M, Itoh S　J. Biochem.　159　27-30　2016　
  • [Original paper]　TGF-β signaling enhancement by long-term exposure to hypoxia in a tumor microenvironment composed of Lewis lung carcinoma cells.　Furuta C, Miyamoto T, Takagi T, Noguchi Y, Kaneko J, Itoh S, Watanabe T, Itoh F　Cancer Sci.　106　1524-1533　2015　
  • [Original paper]　Arf6 regulates tumor angiogenesis and growth through HGF-induced endothelial β1 integrin recycling.　 Hongu T, Funakoshi Y, Fukuhara S, Suzuki T, Sakimoto S, Takakura N, Ema M, Takahashi S, Itoh S, Kato M, Hasegawa H, Mochizuki N, Kanaho Y　Nat. Commun.　6　7925　2015　
  • [Original paper]　TGF-β signaling cooperates with AT motif-binding factor-1 for repression of the α-fetoprotein promoter.　Sakata N, Kaneko S, Ikeno S, Miura Y, Nakabayashi H, Dong X-Y, Dong J-T, Tamaoki T, Nakano N, Itoh S　J. Signal Transduc.　2014　970346　2014　
  • [Original paper]　C18 ORF1: a novel negative regulator of TGF-β signaling.　Nakano N, Maeyama K, Sakata N, Itoh F, Akatsu R, Nakata M, Katsu Y, Ikeno S, Vo Nguyen TT, Watanabe Y, Kato M, Itoh S　J. Biol. Chem.　289　12680-12692　2014　
  • [Original paper]　TMEPAI/PMEPA1enhances tumorigenic activities in lung cancer cells.　Vo Nguyen TT, Watanabe Y, Shiba A, Noguchi M, Itoh S, Kato M　Cancer Sci.　105　334-341　2014　
  • [Review]　Implication of TGF-β as a survival factor during tumour development.　Itoh S, Itoh F.　J. Biochem.　151　559-562　2012　
  • [Original paper]　Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice.　Oishi H, Itoh S, Matsumoto K, Ishitobi H, Suzuki R, Ema M, Kojima T, Uchida K, Kato M, Miyata T, Takahashi S　J. Biochem.　152　549-555　2012　
  • [Original paper]　Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions.　Itoh F., Itoh S., Adachi T., Ichikawa K., Matsumura Y., Takagi T., Festing M., Watanabe T., Weinstein M., Karlsson S., Kato M.　Blood　119　5320-5328　2012　
  • [Review]　Inhibitory machinery for the TGF-β family signaling pathway.　Itoh S., Itoh F.　Growth Factors　29　163-173　2011　
  • [Original paper]　Interference of E2-2-mediated effect in endothelial cells by FAM96B through its limited expression of E2-2.　Yang W., Itoh F., Ohya H., Kishimoto F., Tanaka A., Nakano N., Itoh S., Kato M. 　Cancer Sci.　102　1808-1814　2011　
  • [Review]　TGF-βファミリーシグナル抑制機構　伊東　進　医学のあゆみ　234　893-899　2010　
  • [Review]　概論―TGF-βファミリー研究の新しい流れ　宮澤　恵二、伊東　進　実験医学　28　850-855　2010　
  • [Review]　血管新生におけるTGF-βファミリーの役割と疾患　伊東　史子、伊東　進、加藤　光保　実験医学　28　877-882　2010　
  • [Original paper]　Requirement of TCF7L2 for TGF-β-dependent transcriptional activation of the TMEPAI gene.　Nakano N, Itoh S, Watanabe Y, Maeyama K, Itoh F, Kato M.　J. Biol. Chem.　285　38023-38033　2010　
  • [Original paper]　Flk1-GFP BAC Tg mice: an animal model for the study of blood vessel development. 　Ishitobi H., Matsumoto K., Azami T., Itoh F., Itoh S., Takahashi S., Ema M　Exp. Animals　59　615-622　2010　
  • [Original paper]　Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis.　Tanaka A., Itoh F., Nishiyama K., Takezawa T., Kurihara H., Itoh S., Kato M.　Blood　115　4138-4147　2010　
  • [Original paper]　TMEPAI, a transmembrane TGF-β-inducible protein, sequesters from active participation in TGF-β signaling.　Watanabe Y., Itoh S., Goto T., Ohnishi, E., Inamitsu M., Itoh F., Satoh K., Wiercinska E., Yang W., Shi L., Tanaka A., Nakano N., Mommaas A. M., Shibuya H., ten Dijke P., Kato M.　Mol. Cell　37　123-134　2010　
  • [Original paper]　Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation.　Itoh F.#, Itoh S.#, Carvalho R. L. C.#, Adachi T., Ema M., Goumans M.-J., Larsson J., Karlsson S., Takahashi S., Mummery C. L., ten Dijke P., Kato M. (#equally contributed)　Lab. Invest.　89　800-810　2009　
  • [Original paper]　TAL1/SCL relieves the E2-2-mediated repression of VEGFR2 promoter activity.　Tanaka A., Itoh F., Itoh S., Kato M.　J. Biochem.　145　129-135　2009　
  • [Original paper]　Ephrin-A1 promotes the malignant progression of intestinal tumors in Apcmin/+ mice.　Shi L., Itoh F., Itoh S., Takahashi S., Yamamoto M., Kato M　Oncogene　27　3265-3273　2008　
  • [Review]　TGF-βファミリーシグナルとその調節機構　伊東　進、加藤　光保　細胞　39　322-326　2007　
  • [Review]　Negative regulation of TGF-β receptor/Smad signal transduction.　Itoh S., ten Dijke P.　Curr. Opinion Cell Biol.　19　176-184　2007　
  • [Original paper]　Compensatory mechanisms activated during vasculogenesis in mice by TGF-β-receptor deletion.　Carvalho R. L. C. #, Itoh F.#, Goumans M.-J., Lebrin F., Kato M., Takahashi S., Ema M., Itoh S., van Rooijen M., Bertolino P., ten Dijke P., Mummery C. L. (#equally contributed)　J. Cell Sci　120　4269-4277　2007　
  • [Original paper]　Methylation of Smad6 by protein arginine N-methyltransferase 1.　Inamitsu M., Itoh S., Hellman U., ten Dijke P., Kato M.　FEBS Lett.　580　6603-6611　2006　
  • [Original paper]　ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-β/Smad-induced growth arrest of prostate cells.　Noda D.#, Itoh S.#, Watanabe Y., Inamitsu M., Dennler S., Itoh F., Koike S., Danielpour D., ten Dijke P., Kato M. (#equally contributed)　Oncogene　25　5591-5600　2006　
  • [Original paper]　Smad7 and protein phosphatase 1a are critical determinants in the duration of TGF-β/ALK1signaling in endothelial cells.　Valdimarsdóttir G., Goumans M.-J., Itoh F., Itoh S., Heldin C.-H., ten Dijke P　BMC Cell. Biol.　0.3027777778　1-11　2006　
  • [Original paper]　Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells.　Itoh F.#, Itoh S.#, Goumans M.-J., Valdimarsdóttir G., Iso T., Dotto G. P., Hamamori Y., Kedes L., Kato M., ten Dijke P. (#equally contributed)　EMBO J.　23　541-551　2004　
  • [Original paper]　Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFβ/ALK5 signaling.　Goumans M.-J., Valdimarsdóttir G., Itoh S., Lebrin F., Larsson J., Mummery C., Karlsson S., ten Dijke P.　Mol. Cell　12　817-828　2003　
  • [Original paper]　Synthetic triterpenoids enhance TGF-β/Smad signaling.　Suh N., Roberts A. B., Birkey Reffey S., Miyazono K., Itoh S., ten Dijke P., Heiss E. H., Place A. E., Risingsong R., Wiliams C. R., Honda T., Gribble G. W., Sporn M. B.　Cancer Res.　63　1371-1376　2003　
  • [Original paper]　SARA and Hgs attenuate susceptibility to TGF-β1-mediated T cell suppression.　Kunzmann S., Wohlfahrt J. G., Itoh S., Asao H., Komada M., Akdis C. A., Blaser K., Schmidt-Weber C. B.　FASEB J.　17　194-202　2003　
  • [Original paper]　Elucidation of Smad requirement in transforming growth factor-β type I receptor-induced responses.　Itoh S., Thorikay M., Kowanetz M., Moustakas A., Itoh F., Heldin C.-H., ten Dijke P.　J. Biol. Chem.　278　3751-3761　2003　
  • [Review]　Regulation of cell proliferation by Smad proteins.　ten Dijke P., Goumans M.-J., Itoh F., Itoh S.　J. Cell. Physiol.　191　1-16　2002　
  • [Original paper]　Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells.　Valdimarsdóttir G., Goumans M.-J., Rosendahl A., Brugman M., Itoh S., Lebrin F., Sideras P., ten Dijke P.　Circulation　106　2263-2270　2002　
  • [Original paper]　The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-β/Smad signaling.　Itoh F., Divecha N., Brocks L., Oomen L., Janssen H., Calafat J., Itoh S., ten Dijke P.　Gene Cells　7　321-331　2002　
  • [Original paper]　Balancing the activation state of the endothelium via two distinct TGFβ type I receptors.　Goumans M.-J., Valdimarsdóttir G., Itoh S., Rosendahl A., Sideras P., ten Dijke P.　EMBO J　21　1743-1753　2002　
  • [Original paper]　Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads.　Itoh F., Asao H., Sugamura K., Heldin C.-H., ten Dijke P., Itoh S.　EMBO J　20　4132-4142　2001　
  • [Review]　ラボレポート; アットホームなラボ：Dr. Peter ten-Dijke研究室　伊東　進　実験医学　18　1545-1546　2000　
  • [Review]　Signaling of transforming growth factor-β family members through Smad proteins.　Itoh S., Itoh F., Goumans M.-J., ten Dijke P.　Eur. J. Biochem.　267　6954-6967　2000　
  • [Review]　生体内活性型ビタミンD量を調節する酵素遺伝子の解析：くる病骨粗鬆症を予知する遺伝子診断法の確立への基礎的研究　伊東　進　薬学研究の進歩　16　1-5　2000　
  • [Original paper]　Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4.　Morén A., Itoh S., Moustakas A., ten Dijke P., Heldin C.-H.　Oncogene　19　4396-4404　2000　
  • [Original paper]　The transcriptional co-activator p/CAF potentiates TGF-β/Smad signaling.　Itoh S., Ericsson J., Nishikawa J., Heldin C.-H. ten Dijke P.　Nucleic Acids Res.　28　4291-4298　2000　
  • [Original paper]　Smad7 mediates apoptosis induced by transforming growth factor-β in prostatic carcinoma cells. 　Landström M., Heldin N.-E., Bu S., Hermansson A., Itoh S., ten Dijke P., Heldin C.-H.　Curr. Biol.　10　535-538　2000　
  • [Original paper]　Molecular cloing and characterization of a novel human STE20-like kinase, hSLK(1).　Yamada E., Tsujikawa K., Itoh S., Kameda Y., Kohama Y., Yamamoto H.　Biochim. Biophys. Acta　1495　250-262　2000　
  • [Original paper]　Hedgehog creates a gradient of dpp activity in Drosophila wing imaginal discs.　Tanimoto H., Itoh S., ten Dijke P., Tabata T.　Mol. Cell　5　59-71　2000　
  • [Original paper]　Smad and AML proteins synergistically confer transforming growth factor β1 responsiveness to human germ-line IgA genes.　Pardali E.#, Xie X.-Q.#, Tsapogas P., Itoh S., Arvanitidis K., Heldin C.-H., ten Dijke P., Grundström T., Sideras P. (#equally contributed)　J. Biol. Chem.　275　3552-3560　2000　
  • [Original paper]　Xenopus Smad4β is the Co-Smad component of developmentally-regulated transcription factor complexes responsible forinduction of early mesodermal genes.　Howell M., Itoh F., Pierreux C. E., Valgeirsdóttir S., Itoh S., ten Dijke P., Hill C. S.　Dev. Biol.　214　354-369　1999　
  • [Original paper]　The L45 loop in type I receptors for TGF-β family members is a critical determinant in specifying Smad isoform activation.　Persson U.#, Izumi H.#, Souchelnytskyi S., Itoh S., Grimsby S., Engström U., Heldin C.-H., Funa K., ten Dijke P. (#equally contributed)　FEBS Lett.　434　83-87　1998　
  • [Original paper]　Transforming growth factor-β1 induces nuclear export of inhibitory Smad7.　Itoh S.#, Landström M.#, Hermansson A., Itoh F., Heldin C.-H., Heldin N.-E., ten Dijke P. (#equally contributed)　J. Biol. Chem.　273　29195-29201　1998　
  • [Original paper]　Induction of Smad6 and Smad7 mRNA by TGF-β family members and negative feedback function for Smad7 in TGF-β signaling.　Afrakhte M., Morén A., Jossan S., Itoh S., Sampath K., Westermark B., Heldin C.-H., Heldin N.-E., ten Dijke P.　Biochem. Biophys. Res. Commun.　249　505-511　1998　
  • [Original paper]　Intracellular signaling of osteogenic protein-1 through Smad5 activation.　Tamaki K., Souchelnyskyi S., Itoh S., Nakao A., Sampath K., Heldin C.-H., ten Dijke P.　J. Cell. Physiol.　177　355-363　1998　
  • [Original paper]　Identification and functional characterization of a Smad binding element (SBE) in the Jun B promoter that acts as a transforming growth factorβ, activin and bone morphogenetic protein-inducible enhancer.　Jonk L. J. C.#/, Itoh S.#, Heldin C.-H., ten Dijke P., Kruijer W. (#equally contributed)　J. Biol. Chem.　273　 21145-21152　1998　
  • [Original paper]　Effect of 26,26,26,27,27,27-hexafluoro-1,25- dihydroxyvitamin D on the expression of vitamin D-responsive genes in vitamin D-deficient mice.　Yoshimura T., Itoh S., Tsujikawa K., Yamada E., Ishii T., Iemura O., Kameda Y., Mimura T., Kohama Y.　Pharmacology　57　286-294　1998　
  • [Original paper]　Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene.　Dennler S., Itoh S., Vivien D., ten Dijke P., Huet S., Gauthier J.-M.　EMBO J.　17　3091-3100　1998　
  • [Original paper]　Molecular cloning and regulation of a novel guinea pig P450 (CYP3A20) which differs from guinea pig CYP3A14 in only two amino acid residues.　Mori T., Itoh S., Kamataki T.　Biochem. Mol. Biol. Int.　44　1245-1253　1998　
  • [Original paper]　Expression and characterization of dog CYP2D15 using baculovirus expression system.　Tasaki T., Nakamura A., Itoh S., Ohashi K., Yamamoto Y., Masuda M., Iwata H., Kazusaka A., Kamataki T., Fujita S.　J. Biochem.　123　62-168　1998　
  • [Review]　薬物の光学異性体の体内における相互変換のメカニズムに関する研究　鎌滝　哲也、横井　毅、伊東　進、佐久間　勉　臨床薬理の進歩’97　　11-17　1997　
  • [Original paper]　Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs.　Mori T., Itoh S., Ohgiya S., Ishizaki K., Kamataki T.　Arch. Biochem. Biophys.　348　268-277　1997　
  • [Original paper]　Upstream stimulatory factor 1 (USF1) suppresses induction of CYP1A1 mRNA by 3-methylcholanthrene (MC) in HepG2 cells.　Takahashi Y., Nakayama K., Itoh S., Kamataki T.　Biochem. Biophys. Res. Commun.　240　293-297　1997　
  • [Original paper]　Inhibition of the transcription of CYP1A1 gene by the upstream stimulatory factor 1 in rabbits. Competitive binding of USF1 with AhR/Arnt complex.　Takahashi Y., Nakayama K., Itoh S., Fujii-Kuriyama Y., Kamataki T.　J. Biol. Chem.　272　30025-30031　1997　
  • [Original paper]　Identification of Smad7, a TGF-β-inducible antagonist of TGF-β signaling.　Nakao A., Afrakhte M., Morén A., Nakayama T., Christian J. L., Heuchel R., Itoh S., Heldin N.-E., Heldin C.-H., ten Dijke P.　Nature　389　631-635　1997　
  • [Original paper]　Determination of FAD-binding domain in flavin-containing monooxygenase1 (FMO1).　Kubo A., Itoh S., Itoh K., Kamataki T.　Arch. Biochem. Biophys.　345　271-277　1997　
  • [Original paper]　Low activity of aldehyde dehydrogenase (ALDH) in liver of Suncus murinus: possible explanation for high sensitivity to alcohol.　Itoh S., Matsuyama T., Kamataki T.　J. Toxicol. Sci.　22　111-115　1997　
  • [Original paper]　Promoter region of the human eosinophil cationic protein gene.　Itoh S.#, Yamada E.#, Yoshimura T., Iemura O., Tsujikawa K., Mimura T., Kohama Y. (#equally contributed)　Immunogenetics　46　156-158　1997　
  • [Original paper]　Mouse cytochrome P450 (cyp3a11): predominant expression in liver and capacity to activate aflatoxin B1.　Yanagimoto T., Itoh S., Sawada M., Kamataki T.　Arch. Biochem. Biophys.　340　215-218　1997　
  • [Original paper]　Molecular cloning and characterization of a novel putative STE-like Kinase in guinea pigs.　Itoh S., Kameda Y., Yamada E., Tsujikawa K., Mimura T., Kohama Y.　Arch. Biochem. Biophys.　340　201-207　1997　
  • [Original paper]　Opposite effects of isoniazid and fasting on the expression of CYP2E1 protein and mRNA in house musk shrew (Suncus murinus).　Nakura H., Itoh S., Kusano H., Ishizone H., Kamataki T.　Biochem. Mol. Biol. Int.　41　293-301　1997　
  • [Original paper]　Molecular cloning of mouse liver flavin containing monooxygenase (FMO1) cDNA and characterization of the expression product: metabolism of the neurotoxin, 1,2,3,4-tetrahydroisoqinoline (TIQ).　Itoh K., Nakamura K., Kimura T., Itoh S., Kamataki T.　J. Toxicol. Sci.　22　47-58　1997　
  • [Original paper]　Isolation of a promoter region in mouse Cytochrome P450 3A (Cyp3A16) gene and its transcriptional control.　Itoh S., Abe Y., Kubo A., Okuda M., Shimoji M., Nakayama K., Kamataki T.　Biochim. Biophys. Acta　1350　155-158　1997　
  • [Original paper]　Simultaneous expression of ferredoxin, ferredoxin reductase and P450 in COS7 cells.　Itoh S.#, Iemura O.#, Yoshimura T., Tsujikawa K., Yamada E., Nonaka Y., Okamoto M., Mimura T., Kohama Y. (#equally contributed)　Biochim. Biophys. Acta　1318　284-290　1997　
  • [Original paper]　Gene structure of mouse Cyp3a11: evidence for an enhancer element within its 5' flanking sequences.　Toide K., Itoh S., Nagasaka Y., Yanagimoto T., Kamataki T.　Arch. Biochem. Biophys.　338　43-49　1997　
  • [Review]　好酸球分化?成熟に関連したシグナル分子　伊東　進、小濱　靖弘、三村　務　Molecular Medicine　33　594-601　1996　
  • [Review]　カルシウムホメオスタシス：活性型ビタミンD3生合成?代謝酵素　伊東　進、小濱　靖弘、三村　務　Molecular Medicine　33　213-214　1996　
  • [Original paper]　Expression of aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (Arnt) in adult rabbits known to be non-responsive to cytochrome P-450 1A1 (CYP1A1) inducers.　Takahashi Y., Nakayaka K., Shimojima T., Itoh S., Kamataki T.　Eur. J. Biochem.　242　512-518　1996　
  • [Original paper]　Application of primary hepatocytes from p53-knockout mice for studies of expression of Cyp3a.　Shimoji M., Itoh S., Toide K., Nakayama K., Aizawa S., Kamataki T.　J. Biochem.　120　42-48　1996　
  • [Original paper]　Increase of cytochrome b mRNA by bis(2-hydroxyethyl) trisulfide in J774A.1 cells.　Kohama Y., Iida K., Itoh S., Tsujikawa K., Mimura T.　Biol. Pharm. Bull.　19　876-878　1996　
  • [Original paper]　Expression of CYP3A7, a human fetus-specific cytochrome P450, in cultured cells and in the hepatocytes of p53-knockout mice.　Kamataki T., Hashimoto H., Shimoji M., Itoh S., Nakayama K., Hattori K., Yokoi T., Katsuki M., Aizawa S.　Toxicol. Lett.　82/83　879-882　1995　
  • [Original paper]　S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)- thiazolidin-4-one hydrochloride by rat hepatic flavin-containing monooxygenase 1 expressed in yeast.　Nunoya K., Yokoi T., Itoh K., Itoh S., Kimura K., Kamataki T.　Xenobiotica　25　1283-1291　1995　
  • [Original paper]　Establishment of immortal hepatocytes from a CYP3A7-transgenic/p53- knockout mouse.　Shimoji M., Hattori K., Itoh S., Nakayama K., Katsuki M., Aizawa S., Yokoi T., Kamataki T.　Biochem. Biophys. Res. Commun.　21　1001-1005　1995　
  • [Original paper]　Tuna muscle peptide, PTHIKWGD, inhibits leukocyte-mediated injury and leukocyte adhesion to cultured endothelial cells.　Kohama Y., Kuroda T., Itoh S., Mimura T.　Biol. Pharm. Bull.　19　139-141　1995　
  • [Original paper]　cDNA cloning of mouse ferredoxin reductase from kidney.　Itoh S.#, Iemura O.#, Yamada E., Yoshimura T., Tsujikawa K., Kohama Y., Mimura T. (#equally contributed)　Biochim. Biophys. Acta.　1264　159-162　1995　
  • [Original paper]　Molecular cloning of 25-hydroxyvitamin D3 24-hydroxylase (Cyp-24) from mouse kidney: its inducibility by vitamin D3.　Itoh S.#, Yoshimura T.#, Iemura O., Yamada E., Tsujikawa K., Kohama Y., Mimura T. (#equally contributed)　Biochim. Biophys. Acta.　1264　26-28　1995　
  • [Original paper]　Pharmacological activity of chemically modified subfragment from human serum IgG. XIV. Effect of carboxamide-methylated light chain (G1L) on tyrosine phosphorylation and tumor necrosis factor-α (TNF-α) production from murine macrophages stimulated by lipopolysaccharide (LPS).　Mimura T, Takeuchi K., Hiramatsu K., Tsujikawa K., Kohama Y., Itoh S.　Biol. Pharm. Bull.　18　1377-1381　1995　
  • [Original paper]　Mouse cytochrome P450 linked ferredoxin: its cDNA cloning and inducibility by dibutyryladenosine 3',5'-cyclic monophosphate and forskolin.　Itoh S.#, Iemura O#., Yamada E., Yoshimura T., Tsujikawa K, Kohama Y., Mimura T. (#equally contributed)　Biochim. Biophys. Acta　1263　173-175　1995　
  • [Original paper]　Simultaneous expression of human CYP3A7 and N-acetyltransferase in chinese hamster CHL cells results in high cytotoxicity for carcinogenic heterocyclic amines.　Hashimoto H., Yanagawa Y., Sawada M., Itoh S., Deguchi T., Kamataki T.　Arch. Biochem. Biophys.　320　323-329　1995　
  • [Original paper]　Evidence for lack of hepatic N- acetyltransferase in suncus (Suncus murinus).　Nakura H., Itoh S., Kusano H., Ishizone H., Deguchi T., Kamataki T.　Biochem. Pharmacol.　50　1165-1170　1995　
  • [Original paper]　N-Oxygenation of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine by the rat liver flavin-containing monooxygenase expressed in yeast cells.　Chiba K., Kobayashi K., Itoh K., Itoh S., Chiba T., Ishizaki T., Kamataki T.　Eur. J. Pharmacol.　293　 97-100　1995　
  • [Original paper]　Fetus-specific CYP3A7 and adult-specific CYP3A4 expressed in chinese hamster CHL cells have similar capacity to activate carcinogenic mycotoxins.　Hashimoto H., Nakagawa T., Yokoi T., Sawada M., Itoh S., Kamataki T.　Cancer Res.　55　787-791　1995　
  • [Review]　ダイオキシンと結合する転写調節因子　伊東　進　ファルマシア　30　633-634　1994　
  • [Original paper]　A novel form of mouse cytochrome P450 3A (cyp3a-16): its cDNA cloning and expression in fetal liver.　Itoh S., Satoh M., Abe Y., Hashimoto H., Yanagimoto T., Kamataki T.　Eur. J. Biochem.　226　877-882　1994　
  • [Original paper]　Molecular cloning and functional expression of a mouse cytochrome P450 (cyp3a-13): examination of cyp3a-13 enzyme to activate aflatoxin B1 (AFB1).　Yanagimoto T., Itoh S., Sawada M., Hashimoto H., Kamataki T.　Biochim. Biophys. Acta　1201　405-410　1994　
  • [Original paper]　Studies on thermophile products. X. Further biological properties of isofatty acid-containing phosphatidylglycerol that enhances the induction of suppressor T cells.　Kohama Y., Semba T., Tanaka K., Iida K., Moriyama K., Suda T., Tone H., Itoh S., Mimura T.　Biol. Pharm. Bull.　17　1446-1450　1994　
  • [Original paper]　Characterization of the human Ah receptor promoter in human liver cell line, HepG2.　Takahashi Y., Itoh S., Shimojima T., Kamataki T.　Pharmacogenetics　4　219-222　1994　
  • [Original paper]　Studies on thermophile products. IX. Isofatty acid-containing phosphatidylglycerol that enhances the induction of concanavalin A-activated suppressor T cells.　Kohama Y., Semba T., Tanaka K., Tone H., Tanaka S., Itoh S., Mimura T.　Biol. Pharm. Bull.　17　1171-1175　1994　
  • [Original paper]　Studies on thermophile products. VIII. Isolation of Bacillus stearothermophilus UBT8038, a Ccomponent that inhibits antigen presentation on mouse macrophages.　Kohama Y., Itoh M., Tanaka K., Semba T., Itoh S., Mimura T.　Biol. Pharm. Bull.　17　889-893　1994　
  • [Original paper]　Inhibitory effect of tuna peptide on endothelin production in cultured endothelial cells.　Kohama Y., Kuroda T., Iida K., Itoh S., Mimura T.　Biol. Pharm. Bull.　17　886-888　1994　
  • [Original paper]　Studies on thermophile products. VII. Effect of 1,3-di-methylpentadecanoyl glycerol and its related isofatty acids on T cell proliferation in vitro.　Kohama Y., Tanaka K., Takae S., Semba T., Tone H., Itoh S., Inada A., Nakanishi T., Mimura T.　Biol. Pharm. Bull.　17　850-852　1994　
  • [Original paper]　Stereoselective S-oxidation of flosequinan sulfide by rat hepatic flavin-containing monooxygenase 1A1 expressed in yeast.　Kashiyama E., Yokoi T., Itoh K., Itoh S., Odomi M., Kamataki T.　Biochem. Pharmacol.　47　1357-1363　1994　
  • [Original paper]　Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.　Harada H., Takahashi E., Itoh S., Harada K., Hori T., Taniguchi T.　Mol. Cell. Biol.　14　1500-1509　1994　
  • [Original paper]　Sex-related difference in the expression of cytochrome P450 in hamsters: cDNA cloning and examination for the expression of three distinct CYP2C cDNAs.　Sakuma T., Masaki K., Itoh S., Yokoi T., Kamataki T.　Mol. Pharmacol.　45　228-236　1994　
  • [Original paper]　Activities of drug-metabolizing enzymes in liver of Suncus murinus (suncus): possible lack of N-acetyltransferase activity in liver cytosol.　Nakura H., Itoh S., Kusano H., Ishizone H., Kamataki T.　Pharmacology　48　201-204　1994　
  • [Original paper]　Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers and its transcriptional control.　Hashimoto H., Toide K., Kitamura R., Fujita M., Tagawa S., Itoh S., Kamataki T.　Eur. J. Biochem.　218　585-595　1993　
  • [Original paper]　High susceptibility to aflatoxin B1 and benzo(a)pyrene of BALB3T3 A31-1-1 cells expressing monkey CYP1A1.　Itoh S., Tagawa S., Sawada M., Kamataki T.　J. Toxicol. Sci.　18　207-210　1993　
  • [Original paper]　Human Ah receptor cDNA: analysis for highly conserved sequences.　Itoh S., Kamataki T.　Nucleic Acids Res.　21　3578　1993　
  • [Original paper]　Rat liver flavin-containing monooxygenase (FMO): cDNA cloning and expression in yeast.　Itoh K., Kimura T., Yokoi T., Itoh S., Kamataki T.　Biochim. Biophys. Acta　1173　165-171　1993　
  • [Original paper]　Decrease in the content of cytochrome P-450IIE1 by fasting in liver microsomes of house musk shrew (Suncus murinus).　Nakura H., Itoh S., Kusano H., Ishizone H., Imaoka S., Funae Y., Yokoi T., Kamataki T.　Biochem. Pharmacol.　43　1907-1910　1992　
  • [Original paper]　Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone.　Yanagimoto T., Itoh S., Muller-Enoch D., Kamataki T.　Biochim. Biophys. Acta　1130　329-332　1992　
  • [Original paper]　Genomic organization of human fetal specific P-450IIIA7 (cytochrome P-450HFLa)-related gene(s) and interaction of transcriptional regulatory factor with its DNA element in the 5' flanking region.　Itoh S., Yanagimoto T., Tagawa S., Hashimoto H., Kitamura R., Nakajima Y., Okochi T., Fujimoto S., Uchino J., Kamataki T.　Biochim. Biophys. Acta　1130　133-138　1992　
  • [Original paper]　Stable expression of cytochrome P-450IIIA7 cDNA in human breast cancer cell line MCF-7 and application to cytotoxicity testing.　Kitamura R., Sato K., Sawada M., Itoh S., Kitada M., Komori M., Kamataki T.　Archs. Biochem. Biophys.　292　136-140　1992　
  • [Original paper]　Specific deletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice.　Yamada G., Ogawa M., Akagi K., Miyamoto H., Nakano N., Itoh S., Miyazaki J., Yamamura K., Taniguchi T.　Proc. Natl. Acad. Sci. USA　88　532-536　1991　
  • [Original paper]　Assignment of human interferon regulatory factor-1 (IRF-1) gene to chromosome 5q23-q31.　Itoh S., Harada H., Nakamura Y., White R., Taniguchi T.　Genomics　10　1097-1099　1991　
  • [Original paper]　Sequence of a cDNA coding for human IRF-2.　Itoh S., Harada H., Fujita T., Mimura T., Taniguchi T.　Nucleic Acids Res.　17　8372　1989　
  • [Original paper]　Transient induction of IL-2 receptor in cultured T cell lines by HTLV-1 LTR-linked Tax-1 gene.　Doi T., Hatakeyama M., Itoh S., Taniguchi T.　EMBO J.　8　1953-1958　1989　
  • [Original paper]　Ligand-dependent selection of the receptor gene: segregation of IL-2 binding activity and anti-Tac reactivity by a single amino acid alteration in the Tac antigen (p55).　Minamoto S., Itoh S., Kono T., Doi T., Hatakeyama M.　Immunol. Lett.　20　139-148　1989　
  • [Original paper]　Studies on pharmacological activation of human serum immunoglobulin G (IgG) by chemical modification and active subfragments. VII. Effect of carboxamidemethylated Fc (CM-Fc) fragment from human serum IgG on lymphocyte and macrophages.　Mimura T., Itoh S., Tsujikawa K., Nakajima H., Kohama Y., Okabe M., Iwai M., Ohmura T., Yokoyama K.　Chem. Pharm. Bull.　35　4940-4945　1987　
  • [Original paper]　Studies on pharmacological activation of human serum immunoglobulin G (IgG) by chemical modification and active subfragments. VI. Anti-allergic activity of carboxamidemethylated Fc (CM-Fc) fragment from human serum IgG.　Mimura T., Itoh S., Tsujikawa K., Nakajima H., Kohama Y., Okabe M., Iwai M., Ohmura T., Yokoyama K.　Chem. Pharm. Bull.　35　4935-4939　1987　
  • [Original paper]　Inhibitory effect of bis[2-(E-2-alkenoylamino)ethyl] disulfides and 2-(E-octenoylamino)ethyl carbamoylmethyl sulfide on various inflammation models.　Mimura T., Nakajima H., Kohama Y., Okabe M., Tsujikawa K., Itoh S., Ohmura T., Iwai M., Yokoyama K.　Chem. Pharm. Bull.　35　4585-4591　1987　
  • [Original paper]　Inhibitory effect of bis[2-(E-2-alkenoylamino)ethyl] disulfides and 2-(E-octenoylamino)ethyl carbamoylmethyl sulfides on carrageenin-induced paw edema in rats.　Mimura T., Nakajima H., Kohama Y., Tsujikawa K., Itoh S., Ohmura T., Iwai M. Yokoyama K.　Chem. Pharm. Bull.　35　4579-4584　1987　
  • [Original paper]　Studies on biochemical activities of melanin from marine animals. V. Anti-inflammatory activity of low-molecular-weight melanoprotein from squid (Fr. SMII).　Mimura T., Itoh S., Tsujikawa K., Nakajima H., Satake M., Kohama Y., Okabe M.　Chem. Pharm.Bull.　35　1144-1150　1987　
  • [Original paper]　Studies on pharmacological activation of human serum immunoglobulin g (IgG) by chemical modification and active subfragments. V. Mechanism of anti-inflammatory action of carboxamide-methylated l-chain (Fr. I-L) and H-chain Fr. I-H) from human serum IgG.　Mimura T., Tsujikawa K., Nakajima H., Itoh S., Okabe M., Kohda I., Yokoyama K.　J. Pharmacobio-Dyn.　9　799-805　1986　
  • 原著論文　Cisplatin-induced activation of TGF-β signaling contributes to drug resistance.　118.　Imatsuji S, Ujie Y, Odake H, Imoto M, Itoh S, Tashiro E.　Oncol. Res.　32　139-150　[Related links]
  • 原著論文　Smad7 enhances TGF-β-induced transcription of c-Jun and HDAC6 promoting invasion of prostate cancer cells　112.　Thakur N, Hamidi A, Song J, Itoh S, Bergh A, Heldin CH, Landstr?m M.　iScience　23　101470　[Related links]

Conference, etc.

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  • ポスター発表　Suppression of intestinal tumors in mice lacking TMEPAI which inhibits the TGF-β signaling 　Teppei Shibasaki, Keigo　Sano, Yutaro Sawada, Syoei Amano, Ryo Ishikawa, Fumiko Itoh, Yukihide Watanabe, Makoto M Taketo, Mitsuyasu Kato, Susumu Itoh 　12th International BMP Conference　Ito Hall, University of Tokyo, Tokyo, Japan　2018/10/24～2018/10/28
  • ポスター発表　PDZK1IP1 perturbs TGF-β/ BMP signaling by trapping Smad4 　Naoko Nakano, Souichi Ikeno, Keigo Sano, Nobuo Sakata, Fumiko Itoh, Takashi Minowa, Nobutaka　Hanagata, Makiko Fujii, Susumu Itoh　12th International BMP Conference　Ito Hall, University of Tokyo, Tokyo, Japan　2018/10/24～2018/10/28
  • ポスター発表　TRANSCRIPTIONAL REGULATION OF THE CLAUDIN 4 GENE BY TGF-β　Etsu Tashiro, Mitsuka Takahashi, Aoi Suzuki, Naoko Nakano, Daizo Koinuma, Kohei Miyazono, Susumu Itoh　FASEB Science Research Conferences TGF-β Superfamily　Niagara Falls, NY, USA　2024/7/21-25
  • ポスター発表　ROLE of TMEPAI on INTESTINAL TUMORIGENICITY　Susumu Itoh Naoko Nakano, Yoshimi Uchida, Yuki Matsumoto, Rei Hoshina, Fuma Nitta, Hiroshi Iida, Makoto Mark Taketo, Yukihide Watanabe, Mitsuyasu Kato, Fumiko Itoh　FASEB Science Research Conferences TGF-β Superfamily　Niagara Falls, NY, USA　2024/7/21-25
  • 口頭発表　Role of TMEPAI family in epithelial cell differentiation using genetically modified mouse model: Focusing on oncogenesis　Susumu Itoh　TGF-β signaling Meeting Leiden　Leiden, The Netherlands　2019/8/22～2019/8/24
  • ポスター発表 　Dissociation of AhR/Arnt Complex by TGF-β/Smad Pathway Results in Suppression of CYP1A1 Gene: Inhibition of Benze[a]pyrene-mediated Cytotoxicity by TGF-β 　Susumu Itoh, Naoko Nakano, Keigo Sano, Souichi Ikeno, Nobuo Sakata　FASEB SRC: The TGF-β Superfamily Conference: Signaling in Development and Disease　West Palm Beach, Florida, USA　2019/7/28～2019/8/2
  • 特別講演?シンポジウム　BMP signaling maintains lymphatic function　Fumiko Itoh, Toshihiko Inagawa, Miho Ishibashi, Yuki Saito, Yoshiaki Kubota, Susumu Itoh 　第40回日本分子生物学会年会　パシフィッコ横浜、横浜、神奈川　2018/11/28～2018/11/30
  • 口頭　Endothelial TGF-β/BMP signaling is essential for maintaining vascular funstion 　Fumiko Itoh, Toshihiko Inagawa, Yuki Saito, Miho Ishibashi, Yoshiaki Kubota, Susumu Itoh 　12th International BMP Conference　Ito Hall, University of Tokyo, Tokyo, Japan　2018/10/24～2018/10/28
  • 口頭　Chondrocyte differentiation by coordination between BMP (Bone Morphogenetic Protein)-mediated Smad and non-Smad pathways　Susumu Itoh, Naoko Nakano, Takayuki Shimada, Ayaka Kojima, Kaho Ayabe, Yohei Yamamoto　12th International BMP Conference　Ito Hall, University of Tokyo, Tokyo, Japan　2018/10/24～2018/10/28
  • ポスター発表　TMED10 as a disrupter between TGF-β type I and type II receptor complex　Nakano N, Tsuchiya Y, Kako K, Umezaki K, Sano K, Ikeno S, Otsuka E, Nakagawa A, Sakata N, Itoh F, Iemura S, Natsume T, Itoh S.　FASEB SRC "TGF-β superfamily: signaling in development and disease　Lisbon Marriott Hotel, Lisbon, Portugal　2017/7/9～2017/7/14
  • ポスター発表　TGF-β/Smad signal inhibits benzo(a)pyrene-mediated genetic instability via suppression of CYP1A1 gene　Itoh S, Nakano N, Sano K, Sakata N, Ikeno S, Sato E, Nochise D, Katsu Y, Takahashi Y, Omura K, Yamaguchi S.　FASEB SRC "TGF-β superfamily: signaling in development and disease　 Lisbon Marriott Hotel, Lisbon, Portugal 　2017/7/9～2017/7/14
  • ポスター発表　Inhibitory action of TMEPAI in intestinal tumor　Sano K, Amano S, Ouchi M, Shibasaki T, Aoki Y, Konishi A, Hiruma M, Obokata S, Sawada Y, Itoh F, Watanabe Y, Taketo MM, Kato M, Itoh S.　FASEB SRC "TGF-β superfamily: signaling in development and disease 　Lisbon Marriott Hotel, Lisbon, Portugal 　2017/7/9～2017/7/14
  • [Poster presentation]　網羅的人工的ユビキチン修飾システムの構築　服部隆行、正田卓司、奥平桂一郎、柴田識人、大岡伸通、伊東進、栗原正明、内藤幹彦　日本薬学会第136回年会　横浜、神奈川　2016/03/26～2016/03/29
  • [Poster presentation]　TMED10 dissoicates TGF-β receptor complex to inhibit TGF-β signal.　Nakano N, Itoh F, Itoh S　第74回日本癌学会学術総会　名古屋、愛知　2015/10/08～2015/10/10
  • [Oral presentation]　TMED10 intefers withTGFβ signaling via its extracellular domain.　Itoh S　TGF-β Meeting in Uppsala　Uppsala, Sweden　2015/08/20～2015/08/22
  • [Poster presentation]　ネパール?イラム地方マイポカリ地域における薬用植物 Swertia chirayita の栽培に関する現地調査　高野昭人、 中根孝久、 磯田進、 Yadav P.K.、Kadel D.R.、Malla K.J.、Thapa Y.B.、伊東進　日本植物園協会50周年記念大会?総会　京都、京都　2015/06/25
  • [Poster presentation]　TGF-βシグナル分子欠損マウス胎仔由来線維芽細胞MEFの機能解析　木村真央、柴宏子、中野なおこ、伊東進　第58回日本薬学会関東支部大会　町田、東京　2014/10/04
  • [Poster presentation]　TGF-βはA549細胞においてC/EBPβ及びSREBP-1の発現を誘導する　荻なつみ、竹本友里夏、中野なおこ、伊東進　第58回日本薬学会関東支部大会　町田、東京　2014/10/04
  • [Poster presentation]　TMED10によるTGF-βシグナル抑制機構の解析　木村栄希、加古拳朗、大塚愛理、梅嵜乾隆、土屋裕樹、中野なおこ、伊東進　第58回日本薬学会関東支部大会　町田、東京　2014/10/04
  • [Poster presentation]　TGF-βによるCYP1A1遺伝子発現抑制機構　葛祐妃、菊間美咲、大村佳織、高橋悠太、沼生智晴、福田真弓、中野なおこ、池野聡一、伊東進　第58回日本薬学会関東支部大会　町田、東京　2014/10/04
  • [Poster presentation]　転写因子ATBF1とTGF-βシグナル伝達系によるα-fetoprotein遺伝子プロモーターの協調的抑制　坂田宜夫、金子哲士、池野聡一、三浦裕、中林秀和、Xue-Yuan Dong、Jin-Tang Dong、玉置大器、中野なおこ、伊東進　第58回日本薬学会関東支部大会　町田、東京　2014/10/04
  • [Poster presentation]　PDZK1IP1によるTGF-βファミリーシグナル伝達経路抑制機構　赤津凌介、池野聡一、竹田哲也、中野なおこ、箕輪貴司、花方信孝、伊東史子、伊東進　第58回日本薬学会関東支部大会　町田、東京　2014/10/04
  • [Oral presentation]　TMEPAIファミリーによるTGF-βシグナル制御機構　中野なおこ、赤津凌介、中田美紀、伊東史子、坂田宜夫、葛祐妃、池野聡一、戸川陽子、伊東進　第58回日本薬学会関東支部大会　町田、東京　2014/10/04
  • [Oral presentation]　TMEPAIファミリーによるTGF-βシグナル抑制機構　中野なおこ、伊東史子、渡邊幸秀、加藤光保、伊東進　第73回日本癌学会学術総会　横浜、神奈川　2014/09/25～2014/09/27
  • [Special lecture/Symposium]　Fine-tuning of TGF-β signaling.　Itoh S　1st symposium of SPU Innovative project for Pharmaceutical Anaylses of Covalent Modification in Biomolecules　Machida, Japan　2014/08/28～2014/08/29
  • [Oral presentation]　タバコ含有がん原物質の代謝活性化を司るチトクロームP450遺伝子のTGF-β依存的発現抑制機構と喫煙による肺がんリスク研究　伊東進、池野聡一、中野なおこ、大村佳織、亀田洋子、毛利幸恵　第29回平成25年度公益財団法人喫煙科学研究財団助成研究発表会　新宿、東京　2014/07/15
  • [Oral presentation]　Negative regulation of TGF-β signaling by TMED10.　Itoh S　TGF-β Meeting in Leiden　Leiden, The Netherlands　2014/05/08～2014/05/10
  • [Poster presentation]　Elucidation of the inhibitory mechanism of PDZK1IP1 against TGF-β/Smad signaling.　Ikeno S, Takeda T, Ichikawa D, Nakano N, Minowa T, Hanagata N, Itoh F, Itoh S　TGF-β Meeting in Leiden　Leiden, The Netherlands　2014/05/08～2014/05/10
  • [Poster presentation]　Negative regulation of α-fetoprotein gene transcription by TGF-β/Smad signaling with AT motif binding factor 1 (ATBF1).　Sakata N, Kaneko S, Ikeno S, Miura Y, Nakabayashi H, Dong X-Y, Dong J-T, Tamaki T, Nakano N, Itoh S　TGF-β Meeting in Leiden　Leiden, The Netherlands　2014/05/08～2014/05/10
  • [Poster presentation]　The functional relationship between C18ORF1 and TMEPAI in TGF-β/Smad signaling.　Nakano N, Maeyama K, Sakata N, Itoh F, Akatsu R, Nakata M, Katsu Y, Ikeno S, Togawa Y, Vo Nguyen TT, Watanabe Y, Kato M, Itoh S　TGF-β Meeting in Leiden　Leiden, The Netherlands　2014/05/08～2014/05/10
  • [Poster presentation]　Transcriptional repression mechanisms of TGF-β signaling and ATBF1 on the AFP promoter.　Sakata N, Kaneko S, Iken, S, Miura Y, Nakabayashi H, Dong X-Y, Dong J-T, Tamaoki T, Nakano N, Itoh S.　Joint International Symposium on TGF-β Family and Cancer: Signal Network in Tumor Microenvironment　Tsukuba, Japan　2014/01/12～2014/01/13
  • [Poster presentation]　Negative regulation of α-fetoprotein gene by ATBF1 and TGF-β/Smad signaling.　Sakata N, Kaneko S, Ikeno S, Miura Y, Nakabayashi H, Dong X-Y, Dong J-T, Tamaki T, Nakano N, Itoh S　第36回日本分子生物学会年会　神戸、兵庫　2013/12/03～2013/12/06
  • [Poster presentation]　Fine-tuning of TGF-β signaling by TMEPAI family.　Nakano N, Maeyama K, Ikeno S, Katsu Y, Akatsu R, Togawa Y, Vo Nguyen TT, Itoh F, Watanabe Y, Kato M, Itoh S　第36回日本分子生物学会年会　神戸、兵庫　2013/12/03～2013/12/06
  • [Special lecture/Symposium]　Fine tuning of TGF-β signaling by negative regulators.　Itoh S　The 3rd International Synposium by JSPS Core-to-Core Program "Cooperative International Framework in TGF-β Family Signaling"　Matsuyama, Japan　2013/10/28～2013/10/29
  • [Poster presentation]　TGF-β signaling cooperates with AT motif binding factor 1 (ATBF1) to repress α-fetoprotein gene in human hepatoma cells.　Sakata N, Kaneko S, Ikeno S, Miura Y, Nakabayashi H, Tamaki T, Nakano N, Itoh S　第86回日本生化学会大会　横浜、神奈川　2013/09/11～2013/09/13
  • [Poster presentation]　Inhibitory mechanism of PDZK1IP1 on TGF-β family signaling.　Takeda T, Ikeno S, Ichikawa D, Minowa T, Hanagata N, Itoh F, Itoh S　第86回日本生化学会大会　横浜、神奈川　2013/09/11～2013/09/13
  • [Oral presentation]　TMED10 negatively regulates the TGF-β signaling pathway.　Tsuchiya Y, Umezak Ki, Nakagawa A, Kimura E, Ebisawa M, Sakai K, Itoh F, Iemura S, Natsume T, Nakano N, Ikeno S, Itoh S　第86回日本生化学会大会　横浜、神奈川　2013/09/11～2013/09/13
  • [Oral presentation]　The role of TMEPAI family in TGF-β signaling.　Nakano N, Maeyama K, Ikeno S, Itoh F, Akatsu R, Togawa Y, Ichikawa D, Vo Nguyen TT, Watanabe Y, Kato M, Itoh S　第86回日本生化学会大会　横浜、神奈川　2013/09/11～2013/09/13
  • [Poster presentation]　C18ORF1: a nevel negative regulator of TGF-β signaling.　Itoh S, Nakano N, Maeyama K, Ikeno S, Itoh F, Togawa Y, Katsu Y, Vo Nguyen TT, Watanabe Y, Kato M　FASEB SRC "TGF-β Superfamily: Signaling in Development and Disease　Steamboat Springs, Colorado, USA　2013/07/28～2013/08/02
  • [Poster presentation]　 TGF-β signaling controls tumor blood-and lymph-angiogenesis.　Itoh F, Takagi T, Ichikawa K, Fruttiger M, Oliver G, Watanabe T, Itoh S　FASEB SRC "TGF-β Superfamily: Signaling in Development and Disease　Steamboat Springs, Colorado, USA　2013/07/28～2013/08/02
  • [Poster presentation]　TMEPAI familyによるTGF-βシグナルの制御　中野なおこ、前山宏太、池野聡一、赤津凌介、戸川陽子、市川大輝、Than Thao Vo Nguyen、伊東史子、渡邊幸秀、 加藤光保、伊東進　平成25年度日本生化学会関東支部会例会　甲府、山梨　2013/06/15
  • [Poster presentation]　PDZK1IP1によるTGF-βファミリーシグナル伝達経路抑制機構　池野聡一、竹田哲也、市川大輝、中野なおこ、箕輪貴司、花方信孝、伊東史子、伊東 進　平成25年度日本生化学会関東支部会例会　甲府、山梨　2013/06/15
  • [Oral presentation]　 TMED10, a novel inhibitor of TGF-β signaling.　Itoh S　TGF-β meeting in Uppsala　Uppsala, Sweden　2013/05/30～23013/06/2
  • [Poster presentation]　Negative regulation of TGF-β signaling by TMEPAI family.　Nakano N, Maeyama K, Togawa Y, Watanabe Y, Itoh F, Kato M, Itoh S　第35回日本分子生物学会年会　福岡、福岡　2012/12/11～2012/12/14
  • [Oral presentation]　Dicer-dependent miRNA pathway is important for vascular development.　Itoh F, Hazome S,Fruttiger M, Itoh S, Watanabe T　The 20th Annual Meeting of the Japanese Vascular+F35:H35 Biology and Medicine Organization, The 10th Korea-Japan Joint Symposium on Vascular Biology　Tokushima, Japan　2012/12/05～2012/12/07
  • [Poster presentation]　TGF-β signaling inhibits tumor angiogenesis in vivo.　Takagi T, Itoh F, Fruttiger M, Itoh S, Watanabe T　The 20th Annual Meeting of the Japanese Vascular+F35:H35 Biology and Medicine Organization, The 10th Korea-Japan Joint Symposium on Vascular Biology　Tokushima, Japan　2012/12/05～2012/12/07
  • [Poster presentation]　Endothelial TGF-β signaling inhibits tumor angiogenesis.　Takagi T, Fruttiger, M Itoh S, Noguchi Y, Watanabe T, Itoh F　The 2nd International Symposium by JSPS Core-to-Core Program “Cooperative International Framework in TGF-β Family Signaling”　Machida, Japan　2012/10/29～2012/10/30
  • [Poster presentation]　Lack of TGF-β signaling promotes lymphangiogenesis in vivo.　 Ichikawa K, Oliver G, Itoh S, Watanabe T, Itoh F　The 2nd International Symposium by JSPS Core-to-Core Program “Cooperative International Framework in TGF-β Family Signaling”　Machida, Japan　2012/10/29～2012/10/30
  • [Poster presentation]　Role of TMEPAI family in TGF-β signaling.　Nakano N, Maeyama K, Togawa Y, Watanabe Y, FItoh F, Kato M, Itoh S　The 2nd International Symposium by JSPS Core-to-Core Program “Cooperative International Framework in TGF-β Family Signaling”　Machida, Japan　2012/10/29～2012/10/30
  • [Poster presentation]　PDZK1IP1 acts as a negative regulator for TGF-β family signaling.　Ikeno S, Minowa T, Takeda T, Ichikawa D, Hori E, Kumakura K, Mase Y, Matsumoto T, Miyata M, Sakurai S, Nakano N, Hanagata N, Itoh F, Itoh S　The 2nd International Symposium by JSPS Core-to-Core Program “Cooperative International Framework in TGF-β Family Signaling”　Machida, Japan　2012/10/29～2012/10/30
  • [Special lecture/Symposium]　Negative regulation of TGF-β signaling.　Itoh S　The 2nd International Symposium by JSPS Core-to-Core Program “Cooperative International Framework in TGF-β Family Signaling”　Machida, Japan　2012/10/29～2012/10/30
  • [Oral presentation]　TGF-β/Smad signal blocks B(a)P-induced tumorigenicity.　Itoh S　TGF-β meeting in Leiden　Leiden, The Netherlands　2012/08/29～2012/08/31
  • [Oral presentation]　タバコ含有がん原物質の代謝的活性化を司るチトクロームP450遺伝子のTGF-β依存的発現抑制機構と喫煙による肺がんリスク研究　伊東進、池野聡一、沼生智晴　第27回平成23年度助成研究発表会（公益財団法人）喫煙科学研究財団　新宿、東京　2012/07/18
  • [Poster presentation]　TGF-βによるベンゾ[a]ピレンのCYP1A1発現誘導抑制機構　高橋悠太、沼生智晴、大村佳織、中野なおこ、池野聡一、伊東 進　日本分子 生物学会第12回春季シンポジウム　石和温泉 慶山、山梨　2012/04/25～2012/04/26
  • [Poster presentation]　PDZK1IP1によるTGF-βファミリーシグナル伝達経路抑制機構　池野聡一、宮田麻奈、間瀬佳美、竹田哲也、市川大輝、箕輪貴司、松本朋子、堀絵里子、熊倉健司、桜井早苗、中野なおこ、花方信孝、伊東史子、伊東進　日本分子 生物学会第12回春季シンポジウム　石和温泉 慶山、山梨　2012/04/25～2012/04/26
  • [Poster presentation]　TMED10によるTGF-βシグナル促進機構の解析　梅嵜乾隆、熊倉健司、池野聡一、中野なおこ、家村俊一郎、夏目徹、伊東史子、伊東進　日本分子 生物学会第12回春季シンポジウム　石和温泉 慶山、山梨　2012/04/25～2012/04/26
  • [Poster presentation]　AFF4によるTGF-βシグナル制御機構の解析　土屋裕樹、中野なおこ、家村俊一郎、夏目徹、伊東史子、伊東進　日本分子 生物学会第12回春季シンポジウム　石和温泉 慶山、山梨　2012/04/25～2012/04/26
  • [Poster presentation]　TMEPAI familyによるTGF-βシグナルの抑制機構　中野なおこ、前山宏太、渡邊幸秀、伊東史子、伊東進、加藤光保　日本分子 生物学会第12回春季シンポジウム　石和温泉 慶山、山梨　2012/04/25～2012/04/26
  • [Poster presentation]　TGF-β/Smadシグナル伝達系によるAFP遺伝子転写抑制と転写因子ATBF1との協調作用　坂田宣夫、金子哲士、三浦裕、中林秀和、玉置大器、伊東進　日本分子 生物学会第12回春季シンポジウム　石和温泉 慶山、山梨　2012/04/25～2012/04/26
  • [Special lecture/Symposium]　Role of Smad2 and Smad3 in vascular stability.　Itoh S　The 1st International Symposium by JSPS Core-to-Core Program　Tokyo, Japan　2012/01/23～2012/01/24
  • [Poster presentation]　Negative regulation of TGF-β signaling by transmembrane AR-Smad trapper (TARST) family.　Nakano N, Maeyama K, Watanabe Y, Itoh F, Togawa Y, Itoh S, Kato M　第34回日本分子生物学会年会　横浜、神奈川　2011/12/13～2011/12/16
  • [Poster presentation]　PDZK1IP1 inhibits transforming growth factor-β/Smad signaling.　Ikeno S, Minowa T, Hori E, Kumakura K, Mase Y, Matsumoto T, Miyata M, Sakurai S, Nakano N, Hanagata N, Itoh F, Itoh S　第34回日本分子生物学会年会　横浜、神奈川　2011/12/13～2011/12/16
  • [Poster presentation]　Dicer-dependent miRNA is important for early hematopoiesis but not for angiogenesis.　Itoh F, Matsumura Y, Takagi T, Itoh S, Watanabe T, Kato M　The 19th Annual Meeting of the Japanese Vascular Biology and Medicine Organization　Tokyo, Japan　2011/12/08～2011/12/10
  • [Poster presentation]　Dicer-dependent miRNA pathway is essential for hematopoiesis but not for angiogenesis.　Matsumura Y, Itoh F, Takagi T, Itoh S, Watanabe T, Kato M　JSPS-NOW Joint Seminar　Machida, Japan　2011/11/04～2011/11/06
  • [Special lecture/Symposium]　Involvement of TGF-β/Smad pathway in lymphangiogenesis.　Itoh F, Ichikawa K, Itoh S, Watanabe T　JSPS-NOW Joint Seminar　Machida, Japan　2011/11/04～2011/11/06
  • [Special lecture/Symposium]　Smad2/3 signaling is required for vascular stability.　Itoh S, Itoh F, Kato M　JSPS-NOW Joint Seminar　Machida, Japan　2011/11/04～2011/11/06
  • [Poster presentation]　TGF-β signaling is involved in lymphatic vessel development in vivo.　Itoh F, Matsumura Y, Itoh S, Oliver G, Watanabe T, Kato M　ASEB Summer Research Conferences: The TGF-β superfamily: Signaling in development and diseases　Barga (Lucca), Italy　2011/08/21～2011/08/26
  • [Poster presentation]　Transmembrane AR-Smad Trapper (TARST) family is a negative regulator of TGF-β signaling　Itoh S, Maeyama K, Nakano N, Watanabe Y, Itoh F, Yogawa Y, Kato M.　ASEB Summer Research Conferences: The TGF-β superfamily: Signaling in development and diseases　Barga (Lucca), Italy　2011/08/21～2011/08/26
  • [Poster presentation]　PDZK1IP1 acts as an inhibitory factor for transforming growth factor-β family signaling.　Ikeno S, Minowa T, Hori E, Kumakura K, Mase Y, Matsumoto T, Miyata M, Sakurai S, Nakano N, Hanagata N, Itoh S　ASEB Summer Research Conferences: The TGF-β superfamily: Signaling in development and diseases　Barga (Lucca), Italy　2011/08/21～2011/08/26
  • [Poster presentation]　TCF7L2 coordinates with Smads to regulate TGF-β-mediated transcription of TMEPAI gene.　Nakano N, Watanabe Y, Itoh F, Maeyama K, Ono S, Rika R, Itoh S, Kato M. 　ASEB Summer Research Conferences: The TGF-β superfamily: Signaling in development and diseases　Barga (Lucca), Italy　2011/08/21～2011/08/26
  • [Oral presentation]　Regulation of endothelial cell migration by FAM96B.　Itoh S　 TGF-β meeting in Leiden　Leiden, The Netherlands　2011/08/18～2011/08/20
  • [Special lecture/Symposium]　Negative regulation of TGF-β signaling by TMEPAI and its possible involvement for tumorigenicity　Itoh S.　BMB2010　神戸、兵庫　2010/12/07～2010/12/10
  • [Poster presentation]　血管内皮細胞を可視化するためのFlk-1-GFPおよびFlt1-DsRed BACトランスジェニックマウスの作製　松本健、石飛博之、浅見拓哉、伊東史子、伊東進、田中順子、三輪佳宏、高橋智、依馬正次　BMB2010　神戸、兵庫　2010/12/07～2010/12/10
  • [Poster presentation]　Monoclonal antibody for TMEPAI.　Vo Nguyen TT, Watanabe Y., Itoh S., Kato M.　BMB2010　神戸、兵庫　2010/12/07～2010/12/10
  • [Special lecture/Symposium]　Smad traps, TMEPAI and C18ORF1, for negative regulation of TGF-β signaling.　Kato M., Watanabe Y., Maeyama K., Nakano N., Vo Nguyen TT, Itoh S.　BMB2010　神戸、兵庫　2010/12/07～2010/12/10
  • [Oral presentation]　Regulation of TGF-β signaling by TMEPAI family.　Itoh S.　TGF-β meeting in Leiden　Leiden, The Netherlands　2010/09/01～2010/09/03
  • [Oral presentation]　TGF-βシグナル抑制分子TMEPAI遺伝子の転写制御-TGF-βシグナルとWntシグナルによる協調作用　中野なおこ、加藤光保、伊東進　聖マリアンナ医科大学医学会第59回学術集会　川崎、神奈川　2010/07/22～2010/07/23
  • [Oral presentation]　Vascular endothelial cell-specific Smad2 and Smad3 signaling is required for blood vessel integrity.　Itoh F., Itoh S., Adachi T., Kato M.　The 59th Fujihara International Seminar: Molecular mechanisms of TGF-β signaling and disease　Tomakomai, Japan　2010/07/14～2010/07/17
  • [Poster presentation]　TCF7L2 coordinates with Smads to regulate TGF-β-mediated transcription of TMEPAI gene.　Nakano N., Watanabe Y., Itoh F., Itoh S., Kato M.　The 59th Fujihara International Seminar: Molecular mechanisms of TGF-β signaling and disease　Tomakomai, Japan　2010/07/14～2010/07/17
  • ポスター発表　Endothelial specific depletion of BMP signaling affects vascular function 　Miho　 Ishibashi, Toshihiko Inagawa, Yuki Saito, Takuya　Watanabe, Yoshiaki Kubota, Susumu Itoh, An Zwijsen, Fumiko Itoh　12th International BMP Conference　Ito Hall, University of Tokyo, Tokyo, Japan　2018/10/24～2018/10/28
  • ポスター発表　Depletion of endothelial TGF-β signaling induces both tumor angiogenesis and metastasis　Itoh F, Miyamoto T, Takagi T, Saito Y, Nakano Y, Inagawa T, Sano K, Fruttiger M, Itoh S.　FASEB SRC "TGF-β superfamily: signaling in development and disease 　Lisbon Marriott Hotel, Lisbon, Portugal　 2017/7/9～2017/7/14

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