??.z%R ?0?0?0?0 W?? ?? T ?]?S ?0?0?0 ?QHrt^ DOI URL ?SW???e "Synthesis of a Coumarin-Based PPAR? Fluorescence Probe for Competitive Binding Assay" "Yoshikawa C, Ishida H, Ohashi N, Itoh T." "Int. J. Mol. Sci." 22 4034 2021 10.3390/ijms22084034 ?SW???e "HNF4? Is a Covalent Bond-Forming Receptor." "Kanamori S, Ohashi N, Ishida H, Yamamoto K, Itoh T." "J. Nutr. Sci. Vitaminol." 67 126-129 2021 https://doi.org/10.3177/jnsv.67.126 https://www.jstage.jst.go.jp/article/jnsv/67/2/67_126/_article/-char/ja ?SW???e "Redox-dependent PPAR?/Tnpo1 complex formation enhances PPAR? nuclear localization and signaling." "Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T." "Free Radic. Biol. Med." 156 45-56 2020 10.1016/j.freeradbiomed.2020.06.005 ?SW???e "Insights into PPAR? phosphorylation and its inhibition mechanism" "Montanari R,* Capelli D, Yamamoto K, Awaishima H, Nishikata K, Barendregt A, Heck AJR, Loiodice F, Altieri F, Paiardini A, Grotessi A, Pirone L, Pedone E. M, Peiretti F, Brunel JM, Itoh T,* Pochetti G.*" "J. Med. Chem." 63 4811 4823 2020 10.1021/acs.jmedchem.0c00048 ?SW???e "Preparation and use of turn-on fluorescent probe for detection and live cell imaging of vitamin D receptor as a target protein" "Kojima H,* Itoh T." "STAR Protocols" 1 100036 2020 ?SW???e "Incorporation of a coumarin unit by nucleophilic addition reaction into a PPAR? ligand" "Yoshikawa C, Ishida H, Itoh T." "Tetrahedron Lett. " 61 151842 2020 10.1016/j.tetlet.2020.151842 ?SW???e "Cyclization Reaction-Based Turn-on Probe for Covalent Labeling of Target Proteins" "Kojima H, Fujita Y, Takeuchi R, Ohashi N, Yamamoto K, Itoh T." "Cell Chem. Biol." 27 334-349 2020 10.1016/j.chembiol.2020.01.006 ?SW???e "Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2-arachidonoylglycerol and its congeners in human myeloid leukocytes" "Turcotte C, Archambault AS, Dumais ?, Martin C, Blanchet MR, Bissonnette E, Ohashi N, Yamamoto K, Itoh T, Laviolette M, Veilleux A, Boulet LP, Marzo VD, Flamand N." "FASEB J." 34 4253-4265 2020 10.1096/fj.201902916R ?SW???e "Design and synthesis of selective CYP1B1 inhibitor via dearomatization of ?-naphthoflavone." "Kubo M, Yamamoto K, Itoh T." "Bioorg. Med. Chem." 27 285 304 2019 10.1016/j.bmc.2018.11.045. ?SW???e "Construction of a series of intermediates in the ?-oxidation pathway from THA to EPA via DHA in free acid form." "Kanamori S, Ishida H, Yamamoto K, Itoh T." "Bioorg. Med. Chem." 26 4390-4401. 2018 10.1016/j.bmc.2018.07.004. ?SW???e "Metabolic enhancement of 2,3?,4,4?,5-pentachlorobiphenyl (CB118) using cytochrome P450 monooxygenase isolated from soil bacterium under the presence of perfluorocarboxylic acids (PFCAs) and the structural basis of its metabolism." "Goto E, Haga Y, Kubo M, Itoh T, Kasai C, Shoji O, Yamamoto K, Matsumura C, Nakano T, Inui H." Chemosphere 210 376-383. 2018 10.1016/j.chemosphere.2018.07.026. ?SW???e "Identification of the histidine residue in vitamin D receptor that covalently binds to electrophilic ligands." "Yoshizawa M, Itoh T, Hori T, Kato A, Anami Y, Yoshimoto N, Yamamoto K." "<i>J. Med. Chem.</i>" 61 6339-6349. 2018 10.1021/acs.jmedchem.8b00774. ?SW???e "Structural basis for the selective inhibition of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) by a selenium-containing inhibitor with chloro-aminopyridine as a basic group." "Itoh T, Yoshimoto N, Hirano Y, Yamamoto K." "Bioorg. Med. Chem. Lett." 28 2256 2260. 2018 10.1016/j.bmcl.2018.05.042. ?}?? MD-SAXS?lk0?0?0?0?0?0?0D?S?[SO?0?0?0?0P}T?0?0?0?0n0 N;m'`?WJ0?0s0;m'`;??[?Wn0?n?m?i ??g "n4l8O??0tm,g ?N0tz???^-f0 O??O\0`l?S?n?_0q\,gu`P[" ?e,g>e\IQf[O?? 30 264-276 2017 ?SW???e "On-site reaction for PPAR? modification using a specific bifunctional ligand." "Kojima H, Itoh T, Yamamoto K." "Bioorg. Med. Chem." 25 6492 6500. 2017 10.1016/j.bmc.2017.10.024. ?SW???e "Vitamin D analogues with a p-hydroxyphenyl group at the C25 position: crystal structure of vitamin D receptor ligand-binding domain complexed with the ligand explains the mechanism underlying full antagonistic action." "Kato A, Yamao M, Hashihara Y, Ishida H, Itoh T, Yamamoto K." "J. Med. Chem." 60 8394 8406. 2017 10.1021/acs.jmedchem.7b00819. ?SW???e "A study of synthetic approaches to 2-acyl DHA lysophosphatidic acid." "Yamamoto Y, Itoh T, Yamamoto K." "Org. Biomol. Chem." 15 8186 8192. 2017 ?SW???e "Three-Component Regioselective Synthesis of Tetrahydrofuro[2,3-d]oxazoles and their Efficient Conversion to Oxazoles." "Ohura A, Itoh T, Ishida H, Saito A, Yamamoto K." "Asian J. Org. Chem." 6 673 676. 2017 10.1002/ajoc.201700074 ?SW???e "SRC2-3 binds to vitamin D receptor with high sensitivity and strong affinity." "Egawa D, Itoh T, Kato A, Kataoka S, Anami Y, Yamamoto K." "Bioorg. Med. Chem." 25 568 574. 2017 10.1016/j.bmc.2016.11.020 ?SW???e "17-oxoDHA is a PPAR?/? dual covalent modifier and agonist." "Egawa D, Itoh T, Akiyama Y, Saito T, Yamamoto K" "ACS Chem. Biol." 11 2447"2455. 2016 ?SW???e "Helix12-stabilization antagonist of vitamin D receptor." "Kato A, Anami Y, Egawa D, Itoh T, Yamamoto K" "Bioconjugate Chem." 27 1750-1761 2016 ?}?? ?0?0?0?0?0?0?0h0CYP1n0?0?0?0?0?0?0?0?0?0 O??O\ ?0?0?0?0?0?0?0f[O??? 5 43-46 2016 ?SW???e "Gram scale synthesis of specialized pro-resolving mediator 17(S)-HDHA using lipoxygenase enhanced by water-soluble reducing agent TCEP." "Itoh T, Saito T, Yamamoto Y, Ishida H, Yamamoto K." "Bioorg Med Chem. Lett." 26 343 345 2016 j.bmcl.2015.12.011 10.1021/acs.bioconjchem.5b00021 ?SW???e "Structural determinants of the position of 2,3 ,4,4 ,5-pentachlorobiphenyl (CB118) hydroxylation by mammalian cytochrome P450 monooxygenases.0" "Mise S, Haga Y, Itoh T, Kato A, Fukuda I, Goto E, Yamamoto K, Yabu M, Matsumura C, Nakano T, Sakaki T, Inui H." "Toxicol. Sci." 152 340"348 2016 10.1093/toxsci/kfw086 ?}?? ?0?0?0?0?0?0?0?0?S?[SOn0?i ?L0d0D0k0f?0K0k0? O??O\ ?0?0?0?0?0?0 51 1181 2015 ?}?? "PPAR?/17-oxoDHA J0?0s0 PPAR?/17-oxoDHA n0qQP}vf?i ?" _l?]'Y0W0 O??O\0q\,gu`P[ "Photon Factory Activity Report " 33 299 2015 ?SW???e "Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity. " "Anami Y, Sakamaki Y, Itoh T, Inaba Y, Nakabayashi M, Ikura T, Ito N, Yamamoto K." "Bioorganic. Med. Chem." 23 7274 7281 2015 10.1016/j.bmc.2015.10.026 http://www.sciencedirect.com/science/article/pii/S0968089615301048 ?SW???e "Chemical Synthesis of a Very Long Chain Fatty Acid, Hexacosanoic Acid (C26:0), and the Ceramide Containing Hexacosanoic Acid." "Yamamoto Y, Itoh T, Yamamoto K." "Nutr Sci Vitaminol" 61 222 227 2015 10.3177/jnsv.61.222 ?SW???e "Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting" "Itoh T, Fairall L, Muskett FW, Milano CP, Watoson PJ, Arnaudo N, Saleh A, Millard CJ, El-Mezgueldi M, Martino F, Schwabe JWR." "Nucleic Acids Res" 43 2033-2044 2015 10.1093/nar/gkv068 http://nar.oxfordjournals.org/content/early/2015/02/03/nar.gkv068 ?SW???e "Characterization of covalent bond formation between PPAR? and oxo-fatty acids." "Egawa D, Itoh T, Yamamoto K." "Bioconjugate Chem." 26 690-698 2015 ?SW???e "A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: Active vitamin D analogues with 22R-alkyl group." "Anami Y, Itoh T, Egawa D, Yoshimoto N, Yamamoto K" "J. Med. Chem." 57 4351-4367 2014 ?}?? "Development of vitamin D analogues that modulate the pocket structure of vitamin D receptor. " "Yamamoto K,* Anami Y, Itoh T. " "Curr. Top. Med. Chem." 14 2378-2387 2014 ?}?? "Mammalian cytochrome P450-dependent metabolism of polychlorinated dibenzo-p-dioxins and coplanar polychlorinated biphenyls. " "Inui H, Itoh T, Yamamoto K, Ikushiro S, Sakaki T. " "Int. J. Mol. Sci." 15 14044-14057 2014 ?}?? "Development of vitamin D analogs modulating the pocket structure of vitamin D receptor." "Yamamoto K, Anami Y, Itoh T." "Curr. Top. Med. Chem." 14 2378 2387 2014 10.2174/156802661421141223091909 ?SW???e "Potent antiproliferative effects of 25-hydroxy-16-ene-23-yne-vitamin D3 that resists the catalytic activity of both CYP27B1 and CYP24A1." "Rhieu SY, Annalora AJ, Laporta E, Welsh J, Itoh T, Yamamoto K, Sakaki T, Chen TC, Uskokovic MR, Reddy GS" "J. Cell. Biochem." 115 1392 1402 2014 10.1002/jcb.24789 ?}?? "P}vf?i ?k0?We0O0?0?0?0?0 D ?S?[SO ?0?0?0?0?0?0?0?0?0?0\O(un0RP[?W?vxvz" tz???^-f0 O??O\0_l?]'Y0W0 T,g?fP[0q\,gu`P[ "Photon Factory Activity Report" 31 293 2013 ?SW???e "Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: Selenium coordinates to zinc in enzyme. " "Yoshimoto N, Itoh T, Inaba Y, Ishii H, Yamamoto K." "J. Med. Chem." 56 7527 7535 2013 ?SW???e "Comparison of Metabolism of Sesamin and Episesamin by Drug Metabolizing Enzymes in Human Liver." "Yasuda K, Ikushiro S, Wakayama S, Itoh T, Yamamoto K, Kamakura M, Munetsuna E, Ohta M, Sakaki T" "Drug Metab. Dispos." 40 1917-1926 2012 10.1124/dmd.112.045906. ?SW???e "Butyl pocket formation in the vitamin D receptor strongly affects the agonistic or antagonistic behavior of ligand. " "Yoshimoto N, Sakamaki Y, Haeta M, Kato A, Inaba Y, Itoh T, Nakabayashi M, Ito N, Yamamoto K" "J. Med. Chem." 55 4373-4381 2012 http://pubs.acs.org/doi/abs/10.1021/jm300230a ?SW???e "Substitution at carbon 2 of 19-nor-1?,25-dihydroxyvitamin D3 with 3-hydroxypropyl group generates an analog with enhanced chemotherapeutic potency in PC-3 prostate cancer cells." "Iglesias-Gato D, Zheng S, Flanagan JN, Jiang L, Kittaka A, Sakaki T, Yamamoto K, Itoh T, LeBrasseur NL, Norstedt G, Chen TC" "J. Steroid Biochem. Mol. Biol." 27 269-275 2011 10.1016/j.jsbmb.2011.08.010. ?SW???e "Efficient Synthesis of the Very-Long-Chain n-3 Fatty Acids, Tetracosahexaenoic acid (C24:6n-3) and Tricosahexaenoic acid (C23:6n-3)." "Itoh T, Tomiyasu A, Yamamoto K" Lipids 46 391-397 2011 10.1007/s11745-011-3541-5. ?SW???e "Structural basis of species differences between human and experimental animal CYP1A1s in metabolism of 3,3 ,4,4 ,5-pentachlorobiphenyl." "Yamazaki K, Suzuki M, Itoh T., Yamamoto K, Kanemitsu M, Matsumura C, Nakano T, Sakaki T, Fukami Y, Imaishi H, Inui H" "J. Biochem." 149 487-494 2011 10.1093/jb/mvr009. ?SW???e "Selective inhibition of methoxyflavonoids on human CYP1B1 activity." "Takemura H, Itoh T, Yamamoto K, Sakakibara H, Shimoi K" "Bioorg. Med. Chem." 18 6310-6315 2010 10.1016/j.bmc.2010.07.020. ?SW???e "A 3D model of CYP1B1 explains the dominant 4-hydroxylation of estradiol." "Itoh T, Takemura H, Shimoi K, Yamamoto K" "J. Chem. Inf. Model." 50 1173-1178 2010 http://pubs.acs.org/doi/abs/10.1021/ci1000554 ?SW???e "22S-Butyl-1?,24R-dihydroxyvitamin D3: Recovery of vitamin D receptor agonistic activity." "Inaba Y, Nakabayashi M, Itoh T., Yoshimoto N, Ikura T, Ito N, Shimizu M, Yamamoto K" "J. Steroid Biochem. Mol. Biol." 121 146-150 2010 10.1016/j.bmcl.2010.04.031. ?SW???e "Synthesis of oxidized fatty acid derivatives via an iodolactonization reaction." "Itoh T, Yoshimoto N, Yamamoto K" Heterocycles 80 689-695 2010 http://www.heterocycles.jp/library/abstract.php?article=14282 ?SW???e "Biomimetic Total Synthesis of (?)-8-Oxoerymelanthine." "Yoshida Y, Mohri K, Isobe K, Itoh T, Yamamoto K" "J. Org. Chem." 74 6010-6015 2009 http://pubs.acs.org/doi/abs/10.1021/jo9008645 ?SW???e "Structural basis for the activation of PPAR? by oxidized fatty acids." "Itoh T, Fairall L, Amin K, Inaba Y, Szanto A, Balint BL, Nagy L, Yamamoto K, Schwabe JWR" "Nat. Struct. Mol. Biol." 15 924-931 2008 http://www.nature.com/nsmb/journal/v15/n9/full/nsmb.1474.html ?SW???e "4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor g agonist alleviates the symptoms of DSS-induced colitis." "Yamamoto K, Ninomiya Y, Iseki M, Nakachi Y, Kanesaki-Yatsuka Y, Yamanoue Y, Itoh T, Nishii Y, Petrovsky Y, Okazaki Y " "Biochem. Biophys. Res. Commun." 367 566 572 2008 10.1016/j.bbrc.2007.12.188. ?}?? "Peroxisome proliferator activated receptor ? and oxidized docosahexaenoic acids as new class of ligand. " "Itoh T, Yamamoto K" "Naunyn Schmiedebergs Arch. Pharmacol." 377 541-547 2008 ?SW???e "Synthesis of docosahexaenoic acid derivatives designed PPAR? agonists and antidiabetic agents." "Itoh T, Murota I, Yoshikai K, Yamada S, Yamamoto K" "Bioorg. Med. Chem." 14 98 108 2006 10.1016/j.bmc.2005.07.074 ?SW???e "Identification of putative metabolites of docosahexaenoic acid as potent PPARg agonists and antidiabetic agents." "Yamamoto K,* Itoh T, Abe D, Shimizu M, Kanda T, Koyama T, Nishikawa M, Tamai T, Ooizumie H and Yamada S*" "Bioorg. Med. Chem. Lett." 15 " 517 522" 2005 10.1016/j.bmcl.2004.11.053 ?SW???e "Interaction between Vitamin D Receptor and Vitamin D Ligands: Two-Dimensional Alanine Scanning Mutational Analysis." "Choi M, Yamamoto K, Itoh T, Makishima M, Mangelsdorf DJ, Moras D, DeLuca HF, Yamada S" "Chem. Biol." 10 261-270 2003 10.1016/s1074-5521(03)00050-4 ?SW???e "Asymmetric Synthesis of ( )-Adaline." "Itoh T, Yamazaki N, Kibayashi C" "Org. Lett." 4 2469 2472 2002 https://doi.org/10.1021/ol0200807 ?SW???e "Synthesis of 1-Azaspirocycles via Lewis Acid-Mediated Spirocyclization of Cyclic N-Acyl-N, O-acetal." "Itoh T, Yamazaki N, Kibayashi C" Synlett 1506 1510 2001 10.1055/s-2001-17475 ?SW???e "Asymmetric Synthesis of ( )-Indolizidine 167B and 209D Based on Stereocontrolled Allylaiton of a Chiral Tricyclic N-Acyl-N, O-acetal." "Yamazaki N., Itoh T, Kibayashi C." "Org. Lett." 2 465-467 2000 10.1021/ol990389z ?SW???e "Total synthesis of coccinellid alkaloid ( )-adalinine and the assignment of its absolute configuration." "Yamazaki N, Itoh T, Kibayashi C" "Tetrahedron Lett." 40 739-742 1999 https://doi.org/10.1016/S0040-4039(98)02444-7 ?SW???e "Facile Total Synthesis of (?)-Adalinine." "Yamazaki N, Itoh T, Kibayashi C" Synlett 37-40 1999 10.1055/s-1999-2561