教員

大橋南美講師 / 博士（医学）last update : 2024.12.05

English

プロフィール

研究者名: 大橋南美（オオハシナミ）
所属: 医薬分子化学研究室
担当科目: 生命の化学I (3年次)
メディシナルケミストリー実習 (3年次)　
職位: 講師
学位: 博士（医学）

学歴

2006年3月　神奈川大学理学部生物科学科　卒業

2008年3月　東京医科歯科大学大学院医歯学総合研究科修士課程　修了

2011年3月　東京医科歯科大学大学院医歯学総合研究科博士課程　修了　博士（医学）取得

経歴

2010年4月　日本学術振興会特別研究員DC2

2010年4月　日本学術振興会特別研究員PD　(学位取得による資格変更)

2011年7月　米プリンストン大学　化学科　博士研究員

2012年10月　東京医科歯科大学　生体材料工学研究所　メディシナルケミストリー分野　技術補佐員

2013年4月　同上　研究機関研究員

2015年4月　同上　特任助教

2017年4月　昭和薬科大学　医薬分子化学研究室　特任助教

2019年4月　同上　助教

2023年4月　同上　講師

所属学協会

日本化学会、日本ケミカルバイオロジー学会、日本ビタミン学会、日本ペプチド学会、日本薬学会、日本レチノイド研究会　

研究業績（論文）

タブ区切りテキスト形式でダウンロード

原著論文　Bivalent HIV-1 Fusion Inhibitors Based on Peptidomimetics.　Takuya Kobayakawa, Kento Ebihara, Kohei Tsuji, Takuma Kawada, Masayuki Fujino, Yuzuna Honda, Nami Ohashi, Tsutomu Murakami & Hirokazu Tamamura*　Bioorg. Med. Chem.　28　115812　2020　
原著論文　Synthesis of Hydrophilic Caged DAG-lactones for Chemical Biology Applications.　Takuya Kobayakawa, Hikaru Takano, Takahiro Ishii, Kohei Tsuji, Nami Ohashi, Wataru Nomura, Toshiaki Furuta & Hirokazu Tamamura*　Org. Biomol. Chem.　18　4217-4223　2020　
原著論文　Cyclization Reaction-Based Turn-on Probe for Covalent Labeling of Target Proteins.　Hiroyuki Kojima, Yuki Fujita, Ryosuke Takeuchi, Yuka Ikebe, Nami Ohashi, Keiko Yamamoto & Toshimasa Itoh*　Cell Chem. Biol. 　27　334-349　2020　
原著論文　Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2-arachidonoylglycerol and its congeners in human myeloid leukocytes.　Caroline Turcotte, Anne‐Sophie Archambault, ?lizabeth Dumais, Cyril Martin, Marie‐Renée Blanchet, Elyse Bissonnette, Nami Ohashi, Keiko Yamamoto, Toshimasa Itoh, Michel Laviolette, Alain Veilleux, Louis‐Philippe Boulet, Vincenzo Di Marzo & Nicolas Flamand*　FASEB J.　34　4253-4265　2020　
原著論文　Soluble-type Small-molecule CD4 Mimics as HIV Entry Inhibitors.　Takuya Kobayakawa, Kiju Konno, Nami Ohashi, Kohei Takahashi, Ami Masuda, Kazuhisa Yoshimura, Shigeyoshi Harada* & Hirokazu Tamamura*　Bioorg. Med. Chem. Lett.　29　719-723　2019　
原著論文　Flexibility of small molecular CD4 mimics as HIV entry inhibitors.　Takuya Kobayakawa#, Nami Ohashi# (# Equally contributed), Yuki Hirota, Kohei Takahashi, Yuko Yamada,Tetsuo Narumi, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada? & Hirokazu Tamamura*　Bioorg. Med. Chem.　26　5664-5671　2018　
原著論文　Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands.　Nami Ohashi, Ryosuke Kobayashi, Wataru Nomura, Takuya Kobayakawa, Agnes Czikora, Brienna K Herold, Nancy E. Lewin, Peter M. Blumberg& Hirokazu Tamamura*　Bioconjugate Chem.　28　2135-2144　2017　
原著論文　Development of Anti-HIV Peptides Based on a Viral Capsid Protein.　Takaaki Mizuguchi, Nami Ohashi, Daichi Matsumoto, Chie Hashimoto, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami* & Hirokazu Tamamura*　Biopolymers: Peptide Science　108　e22920　2017　
原著論文　Small-Molecule CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors.　Nami Ohashi, Shigeyoshi Harada, Takaaki Mizuguchi, Yu Irahara, Yuko Yamada, Misato Kotani, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura* & Hirokazu Tamamura*　ChemMedChem a joint special issue with ChemBioChem: Protein–Protein Interactions　11　940-946　2016　
原著論文　Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation.　Linjiao Zhou, Matthew T. Holt, Nami Ohashi, Aishan Zhao, Manuel M. Muller, Boyuan Wang & Tom W. Muir *　Nat. Commun.　7　10589　2016　
原著論文　A minimally cytotoxic CD4 mimic as an HIV entry inhibitor.　Takaaki Mizuguchi, Shigeyoshi Harada, Tomoyuki Miura, Nami Ohashi, Tetsuo Narumi, Hiromi Mori, Yu Irahara, Yuko Yamada, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura* & Tamamura Hirokazu*　Bioorg. Med. Chem. Lett.　26　397-400　2016　
原著論文　Trivalent ligands for CXCR4 bearing polyproline linkers show specific recognition for cells with increased CXCR4 expression.　Wataru Nomura, Taisuke Koseki, Nami Ohashi, Takaaki Mizuguchia & Hirokazu Tamamura*　Org. Biomol. Chem.　13　8734-8739　2015　
原著論文　Anti-HIV Screening for Cell-penetrating Peptides Using Chloroquine and Identification of Anti-HIV Peptides Derived from Matrix Proteins.　Takaaki Mizuguchi, Nami Ohashi, Wataru Nomura, Mao Komoriya, Chie Hashimoto, Naoki Yamamoto, Tsutomu Murakami* & Hirokazu Tamamura*　Bioorg. Med. Chem.　23　4423-4427　2015　
原著論文　An In-cell Fluorogenic Tag-probe System for Protein Dynamics Imaging Enabled by Cell-Penetrating Peptides. 　Wataru Nomura, Nami Ohashi, Atsumi Mori & Hirokazu Tamamura*　Bioconjugate Chem.　26　1080?1085　2015　
原著論文　Screening for Protein Kinase C Ligands Using Fluorescence Resonance Energy Transfer.　Nami Ohashi, Wataru Nomura*, Natsuki Minato & Hirokazu Tamamura*　Chem. Pharm. Bull. (Tokyo).　62　1019-1025　2014　
原著論文　Isostere-based Design of 8-Azacoumarin-type Photolabile Protecting Groups: a Hydrophilicity-increasing Strategy for Coumarin-4-ylmethyls.　Tetsuo Narumi, Hikaru Takano, Nami Ohashi, Akinobu Suzuki, Toshiaki Furuta & Hirokazu Tamamura*　Org. Lett.　16　1184-1187　2014　
原著論文　A CD4 mimic as an HIV entry inhibitor: Pharmacokinetics.　Chie Hashimoto, Tetsuo Narumi, Hiroyuki Otsuki, Yuki Hirota, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Nami Ohashi, Wataru Nomura, Tomoyuki Miura, Tatsuhiko Igarashi, Shuzo Matsushita & Hirokazu Tamamura*　Bioorg. Med. Chem.　21　7884-7889　2013　
原著論文　Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Products.　Wataru Nomura, Haruo Aikawa, Nami Ohashi, Emiko Urano, Mathieu Métifiot, Masayuki Fujino, Kasthuraiah Maddali, Taro Ozaki, Ami Nozue, Tetsuo Narumi, Chie Hashimoto, Tomohiro Tanaka, Yves Pommier, Naoki Yamamoto, Jun A. Komano, Tsutomu Murakami & Hirokazu Tamamura*　ACS Chem. Biol.　8　 2235–2244　2013　
原著論文　CD4 Mimics as HIV Entry Inhibitors: Lead Optimization Studies of the Aromatic Substituents.　Tetsuo Narumi, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Yuki Hirota, Nami Ohashi, Chie Hashimoto, Wataru Nomura, Shuzo Matsushita & Hirokazu Tamamura*　Bioorg. Med. Chem.　21　2518-2526 　2013　
原著論文　Low-Molecular-Weight CXCR4 Ligands with Variable Spacers.　Tetsuo Narumi, Haruo Aikawa, Tomohiro Tanaka, Chie Hashimoto, Nami Ohashi, Wataru Nomura, Takuya Kobayakawa, Hikaru Takano, Yuki Hirota, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura*　ChemMedChem　 8　118-124　2013　
原著論文　Fluorescent-Responsive Synthetic C1b Domains of Protein Kinase C as Reporters of Specific High-Affinity Ligand Binding.　Nami Ohashi, Wataru Nomura*, Tetsuo Narumi, Nancy E. Lewin, Kyoko Itotani, Peter M. Blumberg & Hirokazu Tamamura*　Bioconjugate Chem.　22　82-87　2012　
原著論文　Fluorescence-Quenching Screening of Protein Kinase C Ligands with an Environmentally Sensitive Fluorophore.　Wataru Nomura, Nami Ohashi, Yoshiaki Okuda, Tetsuo Narumi, Teikichi Ikura, Nobutoshi Ito & Hirokazu Tamamura*　Bioconjugate Chem.　22　923-930　2011　
原著論文　Synthetic Caged DAG-lactones for Photochemically Controlled Activation of Protein Kinase C.　Wataru Nomura, Tetsuo Narumi, Nami Ohashi, Yuki Serizawa, Nancy E. Lewin, Peter M. Blumberg, Toshiaki Furuta & Hirokazu Tamamura*　ChemBioChem　12　535-539　2011　
原著論文　Azamacrocyclic Metal Complexes as CXCR4 Antagonists.　Tomohiro Tanaka, Tetsuo Narumi*, Taro Ozaki, Akira Sohma, Nami Ohashi, Chie Hashimoto, Kyoko Itotani, Wataru Nomura, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura*　ChemMedChem　6　834-839　2011　
原著論文　CD4 Mimics Targeting the HIV Entry Mmechanism and Their Hybrid Molecules.　Tetsuo Narumi, Chihiro Ochiai, Kazuhisa Yoshimura, Shigeyoshi Harada, Tomohiro Tanaka, Wataru Nomura, Hiroshi Arai, Taro Ozaki, Nami Ohashi, Matsushita Shuzo & Hirakazu Tamamura*　Bioorg. Med. Chem. Lett.　20　5853-5858　2010　
原著論文　Peptidic HIV Iintegrase Inhibitors Derived from HIV Gene Products: Structure-Activity Relationship Studies.　Shintaro Suzuki, Kasthuraiah Maddali, Chie Hashimoto, Emiko Urano, Nami Ohashi, Tomohiro Tanaka, Taro Ozaki, Hiroshi Arai, Hiroshi Tsutsumi, Tetsuo Narumi, Wataru Nomura, Naoki Yamamoto, Yves Pommier, Jun A. Komano & Hirokazu Tamamura*　Bioorg. Med. Chem.　18　6771-6775　2010　
原著論文　Development of Crosslink-Type Tag-Probe Pairs for Fluorescent Imaging of Proteins.　Wataru Nomura, Tomoaki Mino, Tetsuo Narumi, Nami Ohashi, Akemi Masuda, Chie Hashimoto, Hiroshi Tsutsumi & Hirokazu Tamamura*　Biopolymers: Peptide Science　94　843-852　2010　
原著論文　CD4 Mimics Targeting the Mechanism of HIV entry.　Yuko Yamada, Chihiro Ochiai, Kazuhisa Yoshimura, Tomohiro Tanaka, Nami Ohashi, Tetsuo Narumi, Wataru Nomura, Shigeyoshi Harada, Shuzo Matsushita & Hirokazu Tamamura*　Bioorg. Med. Chem. Lett.　20　354-358　2010　
原著論文　Fluorogenically Active Leucine Zipper Peptides as New Tag-Probe Pairs for Protein Imaging in Living Cells.　Hiroshi Tsutsumi, Wataru Nomura, Seiichiro Abe, Tomoaki Mino, Akemi Masuda, Nami Ohashi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto, Kazunari Akiyoshi & Hirokazu Tamamura*　Angew. Chem., Int. Ed.　48　9164-9166　2009　
原著論文　Structure-activity Relationship Study on Artificial CXCR4 Ligands Possessing the Cyclic Pentapeptide Scaffold: The Exploration of Amino Acid Residues of Pentapeptides by Substitutions of Several Aromatic Amino Acids.　Tomohiro Tanaka, Wataru Nomura*, Tetsuo Narumi, Ai Esaka, Shinya Oishi, Nami Ohashi, Kyoko Itotani, Barry J. Evans, Zi-xuan Wang, Stephen C. Peiper, Nobutaka Fujii & Hirokazu Tamamura*　Org. Biomol. Chem.　7　3805-3809　2009　
原著論文　Synthesis of Protein Kinase Cδ C1b Domain by Native Chemical Ligation Methodology and Characterization of Its Folding and Ligand Binding.　Nami Ohashi, Wataru Nomura*, Mai Kato, Tetsuo Narumi, Nancy E. Lewin, Peter M. Blumberg & Hirokazu Tamamura*　J. Pept. Sci.　15　 642-646　2009　
原著論文　Structure-activity Relationship Study of CXCR4 Antagonists Bearing the Cyclic Pentapeptide Scaffold: Identification of the New Pharmacophore.　Tomohiro Tanaka, Hiroshi Tsutsumi*, Wataru Nomura, Yasuaki Tanabe, Nami Ohashi, Ai Esaka, Chihiro Ochiai, Jun Sato, Kyoko Itotani, Tsutomu Murakami, Kenji Ohba, Naoki Yamamoto, Nobutaka Fujii & Hirokazu Tamamura*　Org. Biomol. Chem.　6　4374-4377 　2008　
原著論文　Versatile Use of Acid-catalyzed Ring-opening of β-Aziridinyl-α,β-enoates to Stereoselective Synthesis of Peptidomimetics.　Hirokazu Tamamura*, Tomohiro Tanaka, Hiroshi Tsutsumi, Koji Nemoto, Satoko Mizokami, Nami Ohashi, Shinya Oishi & Nobutaka Fujii*　Tetrahedron　63　9243-9254　2007　
原著論文　Multimerized CHR-Derived Peptides as HIV-1 Fusion Inhibitors.　Wataru Nomura, Chie Hashimoto, Takaharu Suzuki, Nami Ohashi, Masayuki Fujino, Tsutoms　Murakami, Naoki Yamamoto & Hirokazu Tamamura*　Bioorg. Med. Chem.　21　 4452-4458 　関連リンク

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大橋 南美講師 / 博士（医学）last update : 2024.12.05

プロフィール

学歴

経歴

所属学協会

研究業績（論文）

大橋南美講師 / 博士（医学）last update : 2024.12.05