??.z%R ?0?0?0?0 W?? ?? T ?]?S ?0?0?0 ?QHrt^ DOI URL [Review] "Current Clinical Trial Status and Future Prospects of PPAR-Targeted Drugs for Treating Nonalcoholic Fatty Liver Disease" "Kamata S, Honda A, Ishii I" Biomolecules 13(8) 1264 2023 10.3390/biom13081264 "[Original paper]" "Functional and Structural Insights into the Human PPAR?/?/? Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor." "Kamata S, Honda A, Ishikawa R, Akahane M, Fujita A, Kaneko C, Miyawaki S, Habu Y, Shiiyama Y, Uchii K, Machida Y, Oyama T, Ishii I" Antioxidants 12(8) 1523 2023 10.3390/antiox12081523 "[Original paper]" "2D-DIGE Proteomic Analysis of Mouse Liver Within 1 Week" "Kamata S, Ishii I" "Methods Mol Biol" 2596 217-230 2023 10.1007/978-1-0716-2831-7_16 "[Original paper]" "Functional and Structural Insights into Human PPAR?/?/? Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate." "Honda A, Kamata S, Akahane M, Machida Y, Uchii K, Shiiyama Y, Habu Y, Miyawaki S, Kaneko C, Oyama T, Ishii I." "Int J Mol Sci." 23(9) 4726 2022 10.3390/ijms23094726 "[Original paper]" "A High-Methionine Diet for One-Week Induces a High Accumulation of Methionine in the Cerebrospinal Fluid and Confers Bipolar Disorder-like Behavior in Mice." "Ishii I, Kamata S, Ito S, Shimonaga A, Koizumi M, Tsushima M, Miura A, Nagata T, Tosaka Y, Ohtani H, Kamichatani W, Akahoshi N." "Int J Mol Sci." 23(2) 928 2022 10.3390/ijms23020928 [Review] "PPAR?-Ligand Binding Modes Revealed by X-ray Crystallography" "Kamata S, Ishii I." "Yakugaku Zasshi." 141(11) 1267-1274 2021 10.1248/yakushi.21-00138 "[Original paper]" "Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR ?/? Dual Agonist." "Honda A, Kamata S, Satta C, Machida Y, Uchii K, Terasawa K, Nemoto A, Oyama T, Ishii I." "Biol Pharm Bull." 44(9) 1210-1219 2021 10.1248/bpb.b21-00232 "[Original paper]" "Crystal Structures of the Human Peroxisome Proliferator-Activated Receptor (PPAR)? Ligand-Binding Domain in Complexes with a Series of Phenylpropanoic Acid Derivatives Generated by a Ligand-Exchange Soaking Method." "Oyama T, Kamata S, Ishii I, Miyachi H." "Biol Pharm Bull." 44(9) 1202-1209 2021 10.1248/bpb.b21-00220 "[Original paper]" "Preparation of co-crystals of human PPAR?-LBD and ligand for high-resolution X-ray crystallography." "Kamata S, Oyama T, Ishii I." "STAR Protoc." 2(1) 100364 2021 10.1016/j.xpro.2021.100364 "[Original paper]" "PPAR? Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates." "Kamata S, Oyama T, Saito K, Honda A, Yamamoto Y, Suda K, Ishikawa R, Itoh T, Watanabe Y, Shibata T, Uchida K, Suematsu M, Ishii I." iScience. 23(11) 101727 2020 10.1016/j.isci.2020.101727 "[Original paper]" "Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines." "Kamata S, Hashiyama R, Hana-Ika H, Ohkubo I, Saito R, Honda A, Anan Y, Akahoshi N, Noguchi K, Kanda Y, Ishii I." "Toxicol In Vitro." 69 104999 2020 10.1016/j.tiv.2020.104999 "[Original paper]" "Preeclampsia-Like Features and Partial Lactation Failure in Mice Lacking Cystathionine ?-Lyase-An Animal Model of Cystathioninuria." "Akahoshi N, Handa H, Takemoto R, Kamata S, Yoshida M, Onaka T, Ishii I" "Int J Mol Sci." 20(14) 3507 2019 10.3390/ijms20143507 "[Original paper]" "Abnormal Amino Acid Profiles of Blood and Cerebrospinal Fluid from Cystathionine ?-Synthase-Deficient Mice, an Animal Model of Homocystinuria." "Akahoshi N, Yokoyama A, Nagata T, Miura A, Kamata S, Ishii I" "Biol Pharm Bull." 42(6) 1054-1057 2019 10.1248/bpb.b19-00127 "[Original paper]" "Dietary selenium deficiency or selenomethionine excess drastically alters organ selenium contents without altering the expression of most selenoproteins in mice. " "Akahoshi N, Anan Y, Hashimoto Y, Tokoro N, Mizuno R, Hayashi S, Yamamoto S, Shimada KI, Kamata S, Ishii I." "J Nutr Biochem." 69 120-129 2019 10.1016/j.jnutbio.2019.03.020 "[Original paper]" "2D DIGE proteomic analysis reveals fasting-induced protein remodeling through organ-specific transcription factor(s) in mice." "Kamata S, Yamamoto J, Ohtani H, Tosaka Y, Yoshikawa S, Akahoshi N, Ishii I." "FEBS Open Bio." 8(9) 1524-1543 2018 10.1002/2211-5463.12497 "[Original paper]" "Cystathionine ?-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure." "Szij?rt? IA, Mark? L, Filipovic MR, Miljkovic JL, Tabeling C, Tsvetkov D, Wang N, Rabelo LA, Witzenrath M, Diedrich A, Tank J, Akahoshi N, Kamata S, Ishii I, Gollasch M." Hypertension. 71(6) 1210-1217 2018 10.1161/HYPERTENSIONAHA.117.10562 "[Original paper]" "Rapid 2D DIGE Proteomic Analysis of Mouse Liver." "Kamata S, Ishii I." "Methods Mol Biol" 1664 153-166 2018 10.1007/978-1-4939-7268-5_13 "[Original paper]" "Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates high-fat diet-induced adipocyte hypertrophy and systemic glucose intolerance in mice." "Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, Kawashima M, Asano M, Kajita T, Ishizuka T, Banno Y, Kojima I, Chun J, Kamata S, Ishii I, Morita H." Endocrinology 157 1839-1851 2016 10.1210/en.2015-1768 "[Original paper]" "Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice." "Hagiya Y, Kamata S, Mitsuoka S, Okada N, Yoshida S, Yamamoto J, Ohkubo R, Abiko Y, Yamada H, Akahoshi N, Kasahara T, Kumagai Y, Ishii I." "Toxicol Appl Pharmacol" 282 195-206 2015 10.1016/j.taap.2014.11.015 "[Original paper]" "Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions." "Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M." "J Mol Med (Berl)" 93 879-889 2015 10.1007/s00109-015-1271-5 "[Original paper]" "Involvement of reactive persulfides in biological bismethylmercury sulfide formation." "Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y." "Chem Res Toxicol" 28 1301-1306 2015 10.1021/acs.chemrestox.5b00101 "[Original paper]" "Differential adaptive responses to 1- or 2-day fasting in various mouse tissues revealed by quantitative PCR analysis." "Yamamoto J, Kamata S, Miura A, Nagata T, Kainuma R, Ishii I." "FEBS Open Bio" 5 357-368 2015 10.1016/j.fob.2015.04.012 "[Original paper]" "2D DIGE proteomic analysis highlights delayed postnatal repression of alpha-fetoprotein expression in homocystinuria model mice." "Kamata S, Akahoshi N, Ishii I." "FEBS Open Bio" 5 535-541 2015 10.1016/j.fob.2015.06.008 "[Original paper]" "Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo: participation of reactive persulfides." "Abiko Y, Ishii I, Kamata S, Tsuchiya Y, Watanabe Y, Ihara H, Akaike T, Kumagai Y." "Chem Res Toxicol" 28 1796-1802 2015 10.1021/acs.chemrestox.5b00245 "[Original paper]" "Protective effects of hydrogen sulfide anions against acetaminophen-induced hepatotoxicity in mice." "Ishii I, Kamata S, Hagiya Y, Abiko Y, Kasahara T, Kumagai Y." "J Toxicol Sci" 40 837-841 2015 10.2131/jts.40.837 "[Original paper]" "Dietary deprivation of each essential amino acid induces differential systemic adaptive responses in mice." "Kamata S, Yamamoto J, Kamijo K, Ochiai T, Morita T, Yoshitomi Y, Hagiya Y, Kubota M, Ohkubo R, Kawaguchi M, Himi T, Kasahara T, Ishii I." "Mol Nutr Food Res" 58 1309-1321 2014 10.1002/mnfr.201300758 "[Original paper]" "Neutral aminoaciduria in cystathionine beta-synthase-deficient mice; an animal model of homocystinuria." "Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I." "Am J Physiol Renal Physiol" 306 1462-1476 2014 10.1152/ajprenal.00623.2013 "[Original paper]" "Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine gamma-lyase, an animal model of cystathioninuria." "Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M, Ishii I." "Free Radic Biol Med" 52 1716-1726 2012 10.1016/j.freeradbiomed.2012.02.033