Staff
Isao IshiiProfessor / PhDlast update : 2023.01.16
Japanese
Profile
- Name
- Isao Ishii
- Affiliation
- Health Chemistry
- Subjects
- Sulfur amino acid metabolism (homocysteine, H2S, glutathione)
Lysophospholipid signaling (S1P and LPA)
- Official title
- Professor
- Degree
- PhD
- 2D-DIGE Proteomic Analysis of Mouse Liver Within 1 Week. In: Ohlendieck, K. (eds) Difference Gel Electrophoresis. Methods in Molecular Biology, vol 2596. Shotaro Kamata, Isao Ishii 217–230 Humana, New York, NY. 2023 978-1-0716-2831-
- Methionine: Biosynthesis, Chemical Structure and Toxicity Kamata S,Ishii I Protective roles of transsulfuration against methionine toxicity. 143-153 Nova Science Publishers 2013 978-1-62618-292-9
- [Original Article] Different coactivator recruitment to human PPARα/δ/γ ligand-binding domains by eight PPAR agonists to treat nonalcoholic fatty liver disease Kamata S, Honda A, Kashiwagi N, Shimamura A, Yashiro S, Komori Y, Hosoda A, Akahoshi N, Ishii I Biomedicines 12 624 2024
- [Review] Sphingosine 1-phosphate regulates obesity and glucose homeostasis Kajita K, Ishii I, Mori I, Asano M, Fuwa M, Morita H Int J Mol Sci 25 932 2024
- [Original Article] Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial cells Manandhar S, Chambers S, Miller A, Ishii I, Bhatia M Int J Mol Sci 24 13650 2023
- [Review] Current clinical trial status and future prospects of PPAR-targeted drugs for treating nonalcoholic fatty liver disease Kamata S, Honda A, Ishii I Biomolecules 13 1264 2023
- [Original Paper] Functional and structural insights into the human PPARα/δ/γ targeting preferences of anti-NASH investigational drugs, lanifibranor, seladelpar, and elafibranor Kamata S, Honda A, Ishikawa R, Akahane M, Fujita A, Kaneko C, Miyawaki S, Habu Y, Shiiyama Y, Uchii K, Machida Y, TOyama T, Ishii I Antioxidants 12 1523 2023
- [Original Paper] Synthesis of sulfides and persulfides Is not impeded by disruption of three canonical enzymes in sulfur metabolism Zainol Abidin, Q. H. Ida, T. Morita, M. Matsunaga, T. Nishimura, A. Jung, M. Hassan, N. Takata, T. Ishii, I. Kruger, W. Wang, R. Motohashi, H. Tsutsui, M. Akaike, T. Antioxidants 12 868 2023
- [Review] Amino acids in health and disease: The good, the bad, and the ugly Ishii I, Bhatia M Int J Mol Sci 24 4931 2023
- [Original paper] Differential roles of cystathionine gamma-lyase and mercaptopyruvate sulfurtransferase in hapten-induced colitis and contact dermatitis in mice. Akahoshi N, Hasegawa R, Yamamoto S, Takemoto R, Yoshizawa T, Kamichatani W, Ishii I. Int J Mol Sci 24(3) 2659 2023
- [Original paper] Opposing roles of sphingosine 1-phosphate receptors 1 and 2 in fat deposition and glucose tolerance in obese male mice Asano M, Kajita K, Fuwa M, Kajita T, Mori I, Akahoshi N, Ishii I, Morita H Endocrinology 164 1-13 2023
- [Review] The perspective of PPAR dual/pan agonists as therapeutic drugs against NAFLD Akihiro Honda, Isao Ishii YAKUGAKUZASSHI 142 1335–1343 2022 [Related links]
- [Original Paper] Hydrogen sulfide attenuates lymphedema via the induction of lymphangiogenesis through a PI3K/Akt-dependent mechanism Suzuki J, Shimizu Y, Hayashi T, Che Y, Pu Z, Tsuzuki K, Narita S, Shibata R, Ishii I, Calvert JW, Murohara T J Am Heart Assoc 11 e026889 2022
- [Original Papaer] Functional and Structural Insights into Human PPARα/δ/γ Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate. Honda, A.; Kamata, S.; Akahane, M.; Machida, Y.; Uchii, K.; Shiiyama, Y.; Habu, Y.; Miyawaki, S.; Kaneko, C.; Oyama, T.; Ishii, I. Int J Mol Sci 23 4726 2022
- [Original Papaer] The function of SARS-CoV-2 spike protein is impaired by disulfide-bond disruption with mutation at cysteine-488 and by thiol-reactive N-acetyl-cysteine and glutathione. Murae, M., Shimizu, Y., Yamamoto, Y., Kobayashi, A., Houri, M., Inoue, T., Irie, T., Gemba, R., Kondo, Y., Nakano, Y., Miyazaki, S., Yamada, D., Saitoh, A., Ishii, I., Onodera, T., Takahashi, Y., Wakita, T., Fukasawa, M., Noguchi, K. Biochem Biophys Res Commun 597 30–36 2022
- [Original Papaer] A high-methionine diet for one-week induces a high accumulation of methionine in the cerebrospinal fluid and confers bipolar disorder-like behavior in mice. Ishii, I.; Kamata, S.; Ito, S.; Shimonaga, A.; Koizumi, M.; Tsushima, M.; Miura, A.; Nagata, T.; Tosaka, Y.; Ohtani, H.; Kamichatani, W.; Akahoshi, N. Int. J. Mol. Sci. 23 928 2022
- [Original Paper] The gasotransmitter hydrogen sulfide (H2S) prevents pathologic calcification (PC) in cartilage Nasi S, Ehirchlou D, Bertran J, Castelbianco M, Mitchell J, Ishii I, So A, Busso N Antioxidants 10 1433 2021
- [Review] PPARalpha–Ligand Binding Modes Revealed by X-ray Crystallography Kamata S, Ishii I YAKUGAKUZASSHI 141 1267–1274 2021 [Related links]
- [Review] Role of hydrogen sulfide producing and metabolizing enzymes: Insights from human genetic diseases and their mouse models. Akahoshi N, Ishii I J Jpn Biochem Soc 93 754–759 2021
- [Original Paper] Structural basis for anti-non-alcoholic fatty liver disease and diabetic dyslipidemia drug saroglitazar as a PPARalpha/gamma dual agonist Honda A, Kamata S, Satta C, Machida Y, Uchii K, Terasawa K, Nemoto A, Oyama T, Ishii I Biol Pharm Bull 44 1210–1219 2021
- [Original Paper] Crystal structures of the human peroxisome proliferator-activated receptor (PPAR) alpha ligand-binding domain in complexes with a series of phenylpropanoic acid derivatives generated by a ligand-exchanging soaking method Oyama T, Kamata S, Ishii I, Miyachi H Biol Pharm Bull 44 1202–1209 2021
- [Original Paper] Preparation of human PPARα ligand binding domain–ligand co-crystals for high-resolution X-ray crystallography Kamata S, Oyama T, Ishii I STAR Protocols 2 100364 2021
- [Original paper] PPARα ligand-binding domain structures with endogenous fatty acids and fibrates Kamata S, Oyama T, Saito K, Honda A, Yamamoto Y, Suda K, Ishikawa R, Itoh T, Watanabe Y, Shibata T, Uchida K, Suematsu M, Ishii I iScience 23 101727 2020
- [Original paper] Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines Kamata S, Hashiyama R, Hana-ika H, Ohkubo I, Saito R, Honda A, Anan Y, Akahoshi N, Noguchi K, Kanda Y, Ishii I Toxicol In Vitro 69 104999 2020
- [Original paper] Homocysteine hypothesis on the impaired peripheral but not central nervous system oxytocin responses in cystathionine γ-lyase-deficient dam mice Akahoshi N, Kamichatani W, Ishii I Biol Pharm Bull 43 1810–1813 2020
- [Original Paper] Hydrogen sulphide treatment improves post-infarct remodelling and long-term cardiac function in CSE knockout and wild-type mice Ellmer LJ, Templeton EM, Pilbrow AP, Frampton C, Ishii I, Moore PK, Bhatia M, Richards AM, Cameron VA. Int J Mol Sci 21 4284 2020
- [Original Paper] Repression of mercury accumulation and adverse effects of methylmercury exposure is mediated by cystathionine γ-lyase to produce reactive sulfur species in mouse brain. Akiyama M, Unoki T, Yoshida E, Ding Y, Yamakawa H, Shinkai Y, Ishii I, Kumagai Y.M Toxicol Lett 330 128–133 2020
- [Original Paper] Increased urinary 3-mercaptolactate excretion and enhanced passive systemic anaphylaxis in mice lacking mercaptopyruvate sulfurtransferase, a model of mercaptolactate-cysteine disulfiduria Akahoshi N, Minakawa T, Miyashita M, Sugiyama U, Saito C, Takemoto R, Honda A, Kamichatani W, Kamata S, Anan Y, Ishii I. Int J Mol Sci 21 818 2020
- [Original Paper] Preeclampsia-like features and partial lactation failure in mice lacking cystathionine γ-lyase—an animal model of cystathioninuria. Akahoshi N, Handa H, Takemoto R, Kamata S, Yoshida M, Onaka T, Ishii I. Int J Mol Sci 20 3057 2019
- [Original Paper] Cystathionine-gamma-lyase-derived hydrogen sulfide-regulated substance P modulates liver sieve fenestrations in caecal ligation and puncture-induced sepsis. Gaddam RR, Chambers S, Fraser R, Cogger VC, Le Couture DG, Ishii I, Bhatia M. Int J Mol Sci 20 3191 2019
- [Original Paper] Environmental electrophile-mediated toxicity in mice lacking Nrf2, CSE, or both. Akiyama M, Unoki T, Shinkai Y, Ishii I, Ida T, Akaike T, Yamamoto M, Kumagai Y. Environ Health Perspect 127 67002 2019
- [Original Paper] Dietary selenium deficiency or selenomethionine excess drastically alters organ selenium contents without altering the expression of most selenoproteins in mice. Akahoshi N, Anan Y, Hashimoto Y, Tokoro N, Mizuno R, Hayashi S, Yamamoto S, Shimada K, Kamata S, Ishii I. J Nutr Biochem 69 120-129 2019
- [Original Paper] Abnormal amino acid profiles of blood and cerebrospinal fluid from cystathionine beta-synthase-deficient mice, an animal model of homocystinuria. Akahoshi N, Yokohama A, Nagata T, Miura A, Kamata S, Ishii I. Biol Pharm Bull 42 1054-1057 2019
- [Original Paper] Mutations in homocysteine metabolism genes increase N-homocysteinylation and keratin damage in mice. Borowczyk K, Wróblewski J, Maria Suliburska J, Akahoshi N, Ishii I, Jakubowski H. Int J Genomics 2018 7570850 2018
- [Original Paper] 2D DIGE proteomic analysis reveals fasting-induced protein remodeling through organ-specific transcription factor(s) in mice. Kamata S, Yamamoto J, Ohtani H, Tosaka Y, Yoshikawa S, Akahoshi N, Ishii I. FEBS Open Bio 8 1524-1543 2018
- [Original paper] Cystathionine gamma-lyase-produced hydrogen sulfide controls endothelial NO bioavailability and blood pressure. Szijarto IA, Marko L, Filipovic MR, Miljkovic JL, Tabeling C, Tsvetkov D, Wang N, Rabelo LA, Witzenrath M, Diedrich A, Tank J, Akahoshi N, Kamata S, Ishii I, Goulash M. Hypertension 71 1210-1217 2018
- [Original Paper] Structural and functional insights into S-thiolation of human serum albumins. Nakashima, F. Shibata, T. Kamiya, K. Yoshitake, J. Kikuchi, R. Matsushita, T. Ishii, I. Gimenez-Bastida, J. A. Schneider, C. Uchida, K. Sci Rep 8 932 2018
- [Original Paper] Hydrogen sulfide inhibits the NLRP3 inflammasome and reduces cytokine production both in vitro and in a mouse model of inflammation. Castelblanco, M. Lugrin, J. Ehirchiou, D. Nasi, S. Ishii, I. So, A. Martinon, F. Busso, N. J Biol Chem 293 2546-2557 2018
- [Original Paper] Rapid 2D DIGE proteomic analysis of mouse liver. Kamata, S. Ishii, I. Methods Mol Biol 1664 153-166 2018
- [Original Paper] The Capture of cadmium by reactive polysulfides attenuates cadmium-induced adaptive responses and hepatotoxicity. Akiyama, M. Shinkai, Y. Unoki, T. Shim, I. Ishii, I. Kumagai, Y. Chem Res Toxicol 30 2209-2217 2017
- [Original Paper] Hydrogen sulfide-producing cystathionine gamma-lyase is critical in the progression of kidney fibrosis. Han, S. J. Noh, M. R. Jung, J. M. Ishii, I. Yoo, J. Kim, J. I. Park, K. M. Free Radic Biol Med 112 423-432 2017
- [Original Paper] Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion. Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K. Nucleic Acids Res 45 435-445 2016
- [Original paper] Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. Gaddam R, Fraser R, Badiei A, Chambers S, Cogger V, Couture DL, Ishii I, Bhatia M. PLoS One 11 e0160521 2016
- [Original paper] Immobilization of the Gas Signaling Molecule H2 S by Radioisotopes: Detection, Quantification, and In Vivo Imaging. Sarkar S, Ha YS, Soni N, An GI, Lee W, Kim MH, Huynh PT, Ahn H, Bhatt N, Lee YJ, Kim JY, Park KM, Ishii I, Kang SG, Yoo J. Angew Chem Int Ed Engl 55 9365-9370 2016
- [Original paper] Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Klionsky DJ, Ishii I, et al. Autophagy 12 1-222 2016
- [Original paper] Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates high-fat diet-induced adipocyte hypertrophy and systemic glucose intolerance in mice. Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, Kawashima M, Asano M, Kajita T, Ishizuka T, Banno Y, Kojima I, Chun J, Kamata S, Ishii I, Morita H. Endocrinology 157 1839-1851 2016
- [Original paper] Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation. Wedmann R, Onderka C, Wei S, Szijártó IA, Miljkovic JL, Mitrovic A, Lange M, Savitsky S, Yadav PK, Torregrossa R, Harrer EG, Harrer T, Ishii I, Gollasch M, Wood ME, Galardon E, Xian M, Whiteman M, Banerjee R, Filipovic MR. Chem Sci 7 3414-3426 2016
- [Original paper] Role of cystathionine gamma-lyase in immediate renal impairment and inflammatory response in acute ischemic kidney injury. Markó L, Szijártó I, Filipovic MR, Kaßmann M, Balogh A, Park J-K, Przybyl L, N’diaye G, Kr?mer S, Anders J, Ishii I, Müller DN, Gollasch M Sci Rep 8 27517 2016
- [Original paper] Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice. Hagiya Y, Kamata S, Mitsuoka S, Okada N, Yoshida S, Yamamoto J, Ohkubo R, Abiko Y, Yamada H, Akahoshi N, Kasahara T, Kumagai Y, Ishii I. Toxicol Appl Pharmacol 282 195-206 2015
- [Original paper] Indispensable role of endothelial nitric oxide synthase in caloric restriction-induced cardioprotection against ischemia-reperfusion injury. Shinmura K, Tamaki K, Ito K, Yan X, Yamamoto T, Katsumata Y, Matsuhashi T, Sano M, Fukuda K, Suematsu M, Ishii I. Am J Physiol Heart Circ Physiol 308 894-903 2015
- [Original paper] Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions. Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M. J Mol Med (Berl) 93 879-889 2015
- [Original paper] Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress. Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y. Chem Res Toxicol 28 838-847 2015
- [Original paper] Involvement of reactive persulfides in biological bismethylmercury sulfide formation. Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y. Chem Res Toxicol 28 1301-1306 2015
- [Original paper] Differential adaptive responses to 1- or 2-day fasting in various mouse tissues revealed by quantitative PCR analysis. Yamamoto J, Kamata S, Miura A, Nagata T, Kainuma R, Ishii I. FEBS Open Bio 5 357-368 2015
- [Original paper] 2D DIGE proteomic analysis highlights delayed postnatal repression of alpha-fetoprotein expression in homocystinuria model mice. Kamata S, Akahoshi N, Ishii I. FEBS Open Bio 5 535-541 2015
- [Original paper] The H2S-generating enzymes cystathionine beta-synthase and cystathionine gamma-lyase play a role in vascular development during normal lung alveolarization. Madurga A, Golec A, Pozarska A, Ishii I, Mi?íková I, Nardiello C, Vadász I, Herold S, Mayer K, Reichenberger F, Fehrenbach H, Seeger W, Morty RE. Am J Physiol Lung Cell Mol Physiol 309 710-724 2015
- [Original paper] Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo: participation of reactive persulfides. Abiko Y, Ishii I, Kamata S, Tsuchiya Y, Watanabe Y, Ihara H, Akaike T, Kumagai Y. Chem Res Toxicol 28 1796-1802 2015
- [Original paper] Protective effects of hydrogen sulfide anions against acetaminophen-induced hepatotoxicity in mice. Ishii I, Kamata S, Hagiya Y, Abiko Y, Kasahara T, Kumagai Y. J Toxicol Sci 40 837-841 2015
- [Original paper] Dietary deprivation of each essential amino acid induces differential systemic adaptive responses in mice. Kamata S, Yamamoto J, Kamijo K, Ochiai T, Morita T, Yoshitomi Y, Hagiya Y, Kubota M, Ohkubo R, Kawaguchi M, Himi T, Kasahara T, Ishii I. Mol Nutr Food Res 58 1309-1321 2014
- [Original paper] Neutral aminoaciduria in cystathionine beta-synthase-deficient mice; an animal model of homocystinuria. Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I. Am J Physiol Renal Physiol 306 1462-1476 2014
- [Original paper] The effect of CSE gene deletion in caerulein-induced acute pancreatitis in the mouse. Ang AD, Rivers-Auty J, Hegde A, Ishii I, Bhatia M. Am J Physiol Gastrointest Liver Physiol 305 712-721 2013
- [Original paper] Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes. Okamoto M, Yamaoka M, Takei M, Ando T, Taniguchi S, Ishii I, Tohya K, Ishizaki T, Niki I, Kimura T. Biochem Biophys Res Commun 442 227-233 2013
- [Review] Reconsideration of homocysteinemia. Ishii I. Seikagaku 85 1067-1071 2013
- [Original paper] Protein phosphorylation involved in the gene expression of the hydrogen sulphide producing enzyme cystathionine gamma-lyase in the pancreatic beta-cell. Taniguchi S, Kimura T, Umeki T, Kimura Y, Kimura H, Ishii I, Itoh N, Naito Y, Yamamoto H, Niki I. Mol Cell Endocrinol 350 31-38 2012
- [Original paper] TOF-SIMS imaging of halide/thiocyanate anions and hydrogen sulfide in mouse kidney sections using silver-deposited plates. Akahoshi N, Ishizaki I, Naya M, Maekawa T, Yamazoe S, Horiuchi T, Kajimura M, Ohashi Y, Suematsu M, Ishii I. Anal Bioanal Chem 402 1859-1864 2012
- [Original paper] Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3. Harada Y, Ishii I, Hatake K, Kasahara T. Cancer Lett 319 83-88 2012
- [Original paper] Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway. Morikawa T, Kajimura M, Nakamura T, Hishiki T, Nakanishi T, Yukutake Y, Nagahata Y, Ishikawa M, Hattori K, Takenouchi T, Takahashi T, Ishii I, Matsubara K, Kabe Y, Uchiyama S, Nagata E, Gadalla MM, Snyder SH, Suematsu M. Proc Natl Acad Sci USA 109 1293-1298 2012
- [Original paper] Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine gamma-lyase, an animal model of cystathioninuria. Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M, Ishii I. Free Radic Biol Med 52 1716-1726 2012
- [Review] Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration. Ishii I, Harada Y, Kasahara T. Front Oncol 2 137 2012
- [Original paper] Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria. Ikeda K, Kubo A, Akahoshi N, Yamada H, Miura N, Hishiki T, Nagahata Y, Matsuura T, Suematsu M, Taguchi R, Ishii I. Anal Bioanal Chem 400 1853-1863 2011
- [Original paper] Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2. Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, Himi T, Chun J, Ishii I. Epilepsy Behav 22 659-665 2011
Conference, etc.
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- [Special lecture/Symposium] Possible roles of H2S/RSS and homocysteine in the redox signaling via electrophiles. Ishii I 第9回国際NO学会?第16回日本NO学会学術集会 宮城 2016/05/22
- [Poster presentation] Dietary deprivation of each amino acid induces altered systemic adaptive responses in mice Kamata S, Yamamoto J, Kamijo K, Ochiai T, Morita T, Yoshitomi Y, Hagiya Y, Kubota M, Ohkubo R, Karube K, Kasahara T, Ishii I 第9回国際NO学会?第16回日本NO学会学術集会 宮城 2016/05/21
- [Poster presentation] Dietary deprivation of each essential amino acid induces differential systemic adaptive responses in mice. Kamata S, Yamamoto J, Karube K, Ohkubo R, Kasahara T, Ishii I Experimental Biology 2016 San Diego (USA) 2016/04/04
- [Special lecture/Symposium] H2S and homocysteine: new insights from two hyperhomocysteinemic mutant mice that lack H2S-generating enzymes. Ishii I The 95th German Physiological Society Annual Meeting Lübeck (Germany) 2016/03/05
- [Oral presentation] Novel role of homocysteine for cardiac ischemia/reperfusion injury. 石井功,中埜信太郎,新村健,玉城香代子,菱木貴子,赤星軌征,井田智章,中西豪,鎌田祥太郎,熊谷嘉人,赤池孝章,福田恵一,佐野元昭,末松誠 第39回日本分子生物学会年会?第88回日本生化学会大会合同大会 兵庫 2015/12/04
- [Poster presentation] 絶食によるマウス臓器タンパク質リモデリングの網羅的プロテオーム解析 鎌田祥太郎, 山本隼也, 海沼亮, 大谷遥香, 戸坂優花, 笠原忠, 石井功 第39回日本分子生物学会年会?第88回日本生化学会大会合同大会 兵庫 2015/12/02
- [Poster presentation] 食餌誘導性高ホモシステイン血症感受性マウスの解析 戸坂優花,大谷遥香, 三浦あす美,長田知子,鎌田祥太郎,石井功 第59回日本薬学会関東支部大会 千葉 2015/09/12
- [Poster presentation] 短期絶食によるマウス全身性応答2(臓器別タンパク質発現変化) 大谷遥香, 山本隼也, 戸坂優花, 鎌田祥太郎, 石井功 第59回日本薬学会関東支部大会 千葉 2015/09/12
- [Poster presentation] 短期絶食によるマウス全身性応答1(臓器別遺伝子発現変化) 鎌田祥太郎, 山本隼也, 三浦あす美, 長田知子, 海沼亮, 石井功 第59回日本薬学会関東支部大会 千葉 2015/09/12
- [Special lecture/Symposium] システイン?活性イオウ産生酵素CSEのアセトアミノフェン肝障害における保護的役割 石井功,我孫子ユミ,鎌田祥太郞,熊谷嘉人 第42回日本毒性学会学術年会 金沢 2015/06/30
- [Oral presentation] 高ホモシステイン血症マウスにおける血中α-fetoprotein蓄積 鎌田祥太郎, 赤星軌征, 石井功 第16回Pharmaco-Hematologyシンポジウム 東京 2015/06/13
- [Oral presentation] Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion. 第16回Pharmaco-Hematologyシンポジウム 東京 2015/06/13
- [Poster presentation] 必須アミノ酸欠乏によるマウス個体の適応応答 鎌田祥太郎, 山本隼也, 上條健太, 落合崇人, 森田珠子, 吉冨友里香, 萩谷至史, 久保田将史, 大久保里佳, 長田知子, 三浦あす美, 軽部勝仁, 笠原忠, 石井功 第8回日本アミノ酸学会 学術大会 東京 2014/11/08
- [Poster presentation] 食餌アミノ酸センシングによる摂食抑制 軽部勝仁,三浦あすみ,長田知子,鎌田祥太郎,石井功 第58回日本薬学会関東支部大会 東京 2014/10/4
- [Poster presentation] 絶食によるマウス各臓器の適応応答とリモデリング 山本隼也,鎌田祥太郎,笠原忠,石井功 第87回日本生化学会大会 京都 2014/10/18
- [Poster presentation] Neutral aminoaciduria in cystathionine beta-synthase-deficient mice, an animal model for homocystinuuria. 赤星軌征,鎌田祥太郞,久保田将史,菱木貴子,長畑善子,松浦友美,山﨑千穂,吉田由佳,山田秀典,石﨑泰樹,末松誠,笠原忠,石井功 第87回日本生化学会大会 京都 2014/10/18
- [Oral presentation] マウスにおける各必須アミノ酸欠失餌により異なる適応応答の解析 鎌田祥太郎,山本隼也,上條健太,落合崇人,森田珠子,吉冨友里香,萩谷至史,久保田将史,大久保里佳,笠原忠,石井功 第87回日本生化学会大会 京都 2014/10/18
- [Oral presentation] アセトアミノフェン肝障害に対するトランススルフレーション酵素の保護的役割 石井功,萩谷至史,鎌田祥太郎,光岡紗野,吉田早織,山本隼也,大久保里佳,笠原忠 第87回日本生化学会大会 京都 2014/10/18
- [Poster presentation] 非必須アミノ酸欠乏によるマウス血中アミノ酸濃度変化 長田知子,三浦あす美,山本隼也,鎌田祥太郎,石井功 第58回日本薬学会関東支部大会 東京 2014/10/04
- [Poster presentation] 食餌誘導性高ホモシステイン血症マウスの解析 三浦あす美,長田知子,山本隼也,鎌田祥太郎,石井功 第58回日本薬学会関東支部大会 東京 2014/10/04
- [Oral presentation] 3T3-L1脂肪前駆細胞の脂肪分化に対するホモシステインの効果 菅澤智秋,鎌田祥太郎,石井功 第58回日本薬学会関東支部大会 東京 2014/10/04
- [Poster presentation] Cys生合成酵素欠損マウスにおける肝GSH生合成律速酵素の活性化 光岡紗野,吉田早織,大久保里香,山本隼也,鎌田祥太郎,萩谷至史,笠原忠,石井功 第58回日本薬学会関東支部大会 東京 2014/10/04
- [Poster presentation] アセトアミノフェン肝障害におけるタンパク質発現変化のProteome解析 岡田憲彦,山本隼也,鎌田祥太郎,萩谷至史,笠原忠,石井功 第58回日本薬学会関東支部大会 東京 2014/10/04
- [Special lecture/Symposium] 心虚血再灌流障害におけるホモシステインと硫化水素の拮抗作用 石井功 第14回日本NO学会学術集会 佐賀 2014/05/16
- [Oral presentation] アミノ酸欠乏餌投与によるマウス体重変化と血中アミノ酸濃度変化 久保田将史,吉田早織,吉川紗弓,山本隼也,大久保里香,鎌田祥太郎,萩谷至史,笠原忠,石井功 第57回日本薬学会関東支部大会 東京 2013/10/26
- [Oral presentation] アセトアミノフェン肝障害におけるGlutamate-Cysteine Ligaseの役割 吉田早織,萩谷至史,鎌田祥太郎,大久保里香,笠原忠,石井功 第57回日本薬学会関東支部大会 東京 2013/10/26
- [Oral presentation] ホモシスチン尿症モデルマウス肝臓の2D-DIGEプロテオーム解析 吉川紗弓,鎌田祥太郎,山本隼也,大久保里香,吉田早織,久保田将史,笠原忠,石井功 第57回日本薬学会関東支部大会 東京 2013/10/26
- [Oral presentation] 高ホモシステイン血症モデルマウスの血漿プロテオーム解析 鎌田祥太郎,赤星軌征,吉川紗弓,笠原忠,石井功 第86回日本生化学会大会 神奈川 2013/09/12
- [Oral presentation] アセトアミノフェン肝障害増悪化の遺伝的素因としてのシステイン生合成酵素欠損 萩谷至史,鎌田祥太郎,山本隼也,吉田早織,笠原忠,石井功 第86回日本生化学会大会 神奈川 2013/09/12
- [Oral presentation] マウス臓器種により異な