教員

山崎浩史教授 / 博士（薬学）last update : 2024.10.16

プロフィール

研究者名: 山崎浩史（ヤマザキヒロシ）
所属: 薬物動態学研究室
担当科目: 薬物動態、個別化治療、医薬品相互作用
職位: 教授
学位: 博士（薬学）

学歴

1985年3月　薬学修士（岐阜薬科大学）、1992年2月　博士（薬学）（大阪大学）環境発癌性物質の代謝的活性化におけるチトクロームP-450酵素の役割に関する研究

経歴

1986年4月岐阜薬科大学助手，1987年11月大阪府立公衆衛生研究所研究員，1997年4月同主任研究員、1998年7月金沢大学薬学部助教授、2001年7月北海道大学大学院薬学研究科助教授、2005年4月より現職、2015年4月ー2017年3月本学大学院薬学研究科研究科長

免許?資格

第1種放射線取扱主任者
薬剤師

受賞歴

平成12年度　日本薬学会奨励賞、平成17年度日本薬物動態学会奨励賞、平成20年度　日本薬物動態学会JSSX Felllow、平成26年度日本薬物動態学会学会賞、2023年　国際薬物動態学会学会賞（アジアパシフィック地域）

所属学協会

日本薬学会，日本薬物動態学会，日本臨床薬理学会、日本毒性学会、日本医療薬学会，国際薬物動態学会，米国薬理実験治療学会、米国化学会、トキシコロジー学会など。

日本薬物動態学会代議員（評議員）(2000年～)、Felllow (2008～)、理事(2010-20, 2022-25)、DMPK編集委員長(2014-17)、副会長(2016-17)、会長(2017-19)、年会長(2019-20)、日本薬学会代議員(2008～)、日本臨床薬理学会社員（評議員）(2008～)、International Society of Study of Xenobiotics, Membership Committee member (2008-10), Nomination Committee member (2010, 2016-19), Council member (2011-14、2023-26), Scientific Affairs Committee member (2020-2023).

研究分野

薬物代謝学、薬物動態学

研究業績（著書）

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医療薬学　V．薬物治療に役立つ情報補訂版、第III部　個別化医療　山崎浩史　第10章遺伝的素因　216－227　東京化学同人　2021　
薬物動態学UPDATE 医学のあゆみ　山崎浩史　ヒト肝細胞移植キメラマウスを用いた薬物代謝?動態研究　264, 615-618　医歯薬出版　2018　
「最新薬剤学第11版」　山崎浩史　3-3 薬物の代謝　224-232.　廣川書店　2018　
マーモセットラボマニュアル　はじめての取扱いから研究最前線まで　山崎浩史　マーモセットの薬物代謝、　156-159　アドスリー　2018　
「医療薬物代謝学第二版」　山崎浩史、小澤正吾編著　　　医学評論社　2018　
製剤学改訂第7版　山崎浩史　6-3　薬物の代謝　309-324　南江堂　2017　
医療薬学　V．薬物治療に役立つ情報、第III部　個別化医療　山崎浩史　第10章遺伝的素因　213-223　東京化学同人　2017　
Comprehensive Medicinal Chemistry III: ADME and Toxicology　Yamazaki, H.　Drug Metabolizing Enzyme Systems I　45-50　Elsevier　2017　9780128032008
演習と解説　薬物動態学　山崎浩史、夏目秀視、橋爪孝典編著　山崎浩史　第6章 TDM (Therapeutic Drug Monitoring）と投与設計　　廣川書店　2016　
月刊薬事2016年1月臨時増刊号「臨床の疑問に答えるがん薬物療法アップデート」　清水万紀子、山崎浩史　抗がん薬と薬物代謝酵素　398-407　じほう　2016　
Advances in Medicine and Biology, Vol. 93　Yamazaki, H., Chowdhury, G. and Guengerich, F.P.　Activation of Thalidomide to Reactive Metabolites by Autoinduced Human Cytochrome P450 3A Enzymes, with Substrate Cooperativity, and Implications for Development of Analogs.　23-30　Nova Science Publishers, Inc, 　2016　
「第5版衛生化学－環境と健康－」　山崎浩史　9.1.4.異物代謝の機構　355-362　丸善　2015　
「生物薬剤学改訂第3版」　山崎浩史　薬物代謝反応の過程、薬物代謝反応部位と薬物代謝酵素　95-106　南江堂　2015　
Fifty Years of Cytochrome P450 Research, ed. 　Hiroshi Yamazaki　Chapter　17 Species,Ethnic,and Individual Differences in Human Drug-Metabolizing Cytochrome P450 Enzymes　293-305　Springer　2014　
「薬物動態学第二版」　山崎浩史　第4章「代謝」　81-105　廣川書店　2014

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研究業績（論文）

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Original article, 　Impact of variability of in silico and in vitro octanol/water partition coefficients of compounds on the input parameters and results of simplified human physiologically based pharmacokinetic models after virtual oral administrations. 　Adachi K, Sasaki T, Arai A, Shimizu M, Yamazaki H. 　J Toxcol Sci　49　459-466　2024　関連リンク
Original article, 　Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities.　Kojima, A., Nadai, M., Murayama, N., Yamazaki, H., and Katoh, M. 　Xenobiotica　　in press　2024　関連リンク
Original article, 　Interaction of a caffeine overdose with clinical doses of contraceptive ethinyl estradiol in a young woman.　Adachi, K., Murata, M., Inada, A., Morimoto, T., Shimizu, M., Bepp, S., and Yamazaki, H.　Acute Med Surg　11　e985　2024　関連リンク
Original article, 　Investigation of functional cytochrome P450 4A enzymes in liver and kidney of pigs, cats, tree shrews, and dogs in comparison with the metabolic capacity of human P450 4A11.　Uno, Y., Tsukiyama-Kohara, K., Ishizuka, M., Mizukawa, H., Murayama, N., Yamazaki, H.　Drug Metab Dispos.　52　1009-1019　2024　関連リンク
Original article, 　Quinuclidine N-oxygenation mediated by flavin-containing monooxygenase (FMO) 1 and FMO3 in kidney and liver microsomes from humans, monkeys, dogs, and pigs　Shimizu, M., Makiguchi, M., Uno, Y. and Yamazaki, H.　Drug Metab Dispos　52　906-910　2024　関連リンク
Original article, 　Modeled hepatic/plasma exposures of omeprazole prescribed alone in cytochrome P450 2C19 poor metabolizers are likely associated with hepatic toxicity reported in a Japanese adverse event database.　Adachi, K., Ohyama, K., Tanaka, Y., Murayama, N., Shimizu, M., Saito, Y., and Yamazaki, H. 　Biol Pharm Bull　47　1028-1032　2024　関連リンク
Original article, 　In vivo and in vitro induction of cytochrome P450 3A4 by thalidomide in humanized-liver mice and experimental human hepatocyte HepaSH cells.　Uehara, S., Murayama, N., Higuchi, Y., Shimizu, M., Suemizu, H., Guengerich, F. P., and Yamazaki, H. 　Chem Res Toxicol　37　671-674　2024　関連リンク
Original article, 　Octanol/Water Partition Coefficients Estimated Using Retention Times in Reverse-phase Liquid Chromatography and Calculated in Silico as One of the Determinant Factors for Pharmacokinetic Parameter Estimations of General Chemical Substances.　Adachi, K., Shimizu, M., Shono, F., Funatsu, K., and Yamazaki, H. 　J Toxicol Sci　49　127-137　2024　関連リンク
Original article, 　Time-to-onset Analysis of Rhabdomyolysis due to Different Proton Pump Inhibitors Using a Pharmacovigilance Database. 　Ohyama, K., Iida, M., Akiyama, S., Yamazaki, H., and Hori, Y. 　In Vivo　38　1285-1291　2024　関連リンク
Original article, 　Modeled hepatic/plasma exposures of fluvastatin prescribed alone in subjects with impaired cytochrome P450 2C9*3 as one of possible determinant factors likely associated with hepatic toxicity reported in a Japanese adverse event database.　Adachi K, Ohyama K, Tanaka Y, Saito Y, Shimizu M, Yamazaki H. 　Biol Pharm Bull　47　635-640　2024　関連リンク
Original article, 　Transcript abundance of hepatic drug-metabolizing enzymes in two dog breeds compared with 14 species including humans. 　Uno, Y., Yamato, O., and Yamazaki, H. 　Drug Metab Pharmacokinet　55　101002　2024　関連リンク
Original article, 　Novel tree shrew cytochrome P450 2Ds (CYP2D8a and CYP2D8b) are functional drug-metabolizing enzymes that metabolize bufuralol and dextromethorphan. 　Ushirozako, G., Murayama, N., Tsukiyama-Kohara, K., Yamazaki, H., and Uno, Y. 　Drug Metab Dispos　52　305-311　2024　関連リンク
Original article, 　Identification of cytochrome P450 2C18 and 2C76 in tree shrews: P450 2C18 effectively oxidizes typical human P450 2C9/2C19 chiral substrates warfarin and omeprazole with less stereoselectivity. 　Uno, Y., Minami, Y., Tsukiyama-Kohara, K., Murayama, N., and Yamazaki, H.　Biochem Pharmacol　221　115990　2024　関連リンク
Original article, 　Novel cytochrome P450 2C119 enzymes in cynomolgus and rhesus macaques metabolize progesterone, diclofenac, and omeprazole. 　Uno, Y., Murayama, N., and Yamazaki, H. 　Drug Metab Dispos　52　226-273　2024　関連リンク
Original article, 　Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources 　Shimizu, M., Makiguchi, M., Hishinuma, E., Saito, S., Hiratsuka, M., and Yamazaki, H. 　Drug Metab Pharmacokinet　55　100539　2024　関連リンク
Original article, 　Molecular and functional characterization of flavin-containing monooxygenases (FMO1–6) in tree shrews. 　Uno, Y., Makiguchi, M., Ushirozako, G., Tsukiyama-Kohara, K., Shimizu, M., and Yamazaki, H. 　Comp Biochem Physiol C Toxicol Pharmacol,　227　109835　2024　関連リンク
Original article, 　Pharmacokinetic Models Scaled-up from Humanized-liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated and N-Demethylated Metabolites in Pediatric Patients Genotyped for Cytochrome P450 2D6.　Shimizu, M., Uehara, S., Ohyama, K., Nishimura, H., Tanaka, Y., Saito, Y., Suemizu, H., Yoshida, S., and Yamazaki, H. 　Drug Metab Dispos　52　35-43　2024　関連リンク
Original article, 　Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver. 　Uno, Y., Uehara, S., Ushirozako, G., Masatani, T., and Yamazaki, H. 　Xenobiotica　53　581-5860　2023　関連リンク
Original article, 　Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p-nitrophenol. 　Ushirozako, G., Murayama, N., Tsukiyama-Kohara, K., Yamazaki, H., and Uno, Y. 　Xenobiotica　53　573-580　2023　関連リンク
Original article, 　SGX523 causes renal toxicity through aldehyde oxidase-mediated less-soluble metabolite formation in chimeric mice with humanized livers. 　Uehara, S., Yasuda, M., Higuchi, Y., Yoneda, N., Kawai, K., Suzuki, M., Yamazaki, H., and Suemizu, H. 　Toxicol Lett　388　48-55　2023　関連リンク
Original article, 　Cytochrome P450 1A2 and 2C Enzymes Autoinduced by Omeprazole in Dog Hepatocytes and Human HepaRG and HepaSH Cells Are Involved in Omeprazole 5-Hydroxylation and Sulfoxidation.　Uno, Y., Uehara, S., Ushirozako, G., Murayama, N., Suemizu, H., and Yamazaki, H. 　Xenobiotica　53　465-473　2023　関連リンク
Original article, 　Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1. 　Nagayoshi H, Murayama N, Kim V, Kim D, Takenaka S, Yamazaki H, Guengerich FP, Shimada T. 　Chem Res Toxicol　36　1778–1788　2023　関連リンク
Original article, 　Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection.　Negishi D, Mitsumatsu O, Mitsumatsu H, Makiguchi M, Shimizu M, and Yamazaki H.　J Pharm Health Care Sci　9　33　2023　関連リンク
Original article, 　Simple confirmation methods for rare but impaired variants of human flavin-containing monooxygenase 3 (FMO3) found in an updated genome resource databank. 　Shimizu M, Makiguchi M, Yokota Y, Shimamura E, Matsuta M, Nakamura Y, Harano, M, and Yamazaki H. 　Drug Metab Pharmacokinet　53　100528　2023　関連リンク
Original article, 　The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro　Kojima M, Machida K, Cho S, Watanabe D, Seki H, Shimoji M, Imaoka A, Yamazaki H, Guengerich FP, Nakamura K, Yamamoto K, Akiyoshi T, and Ohtani H. 　Xenobiotica　53　357-365　2023　関連リンク
Original article, 　Variants of Flavin-containing Monooxygenase 3 Found in Subjects in an Updated Database of Genome Resources. 　Makiguchi, M., Shimizu, M., Yokota, Y., Shimamura, E., Hishinuma, E., Saito, S., Hiratsuka, M., and Yamazaki, H. 　Drug Metab Dispos.　51　884-891　2023　関連リンク
Original article, 　Plasma and hepatic exposures of celecoxib and diclofenac prescribed alone in patients with cytochrome P450 2C9*3 modeled after virtual oral administrations and likely associated with adverse drug events reported in a Japanese database　Adachi, K., Ohyama, K., Tanaka, Y., Nakano, H., Sato, T., Murayama, N., Shimizu, M., Saito, Y., and Yamazaki, H. 　Bio Pharm Bull　46　856-863　2023　関連リンク
Original article, 　HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes. 　Uehara, S., Higuchi, Y., Yoneda, N., Ito, R., Takahashi, T., Murayama, N., Yamazaki, H., Murai, K., Hikita, H., and Takehara, T. 　Biochem Biophys Res Commun　663　132-141　2023　関連リンク
Original article, 　Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs　Uno Y, Noda Y, Morikuni S, Murayama N, Yamazaki H. 　Xenobiotica 　53　140-148　2023　関連リンク
Original article, 　Liver and plasma concentrations of food chemicals after virtual oral doses extrapolated using in silico estimated input pharmacokinetic parameters to confirm reported liver toxicity in rats. 　Adachi K., Nakano H., Sato T., Shimizu M., and Yamazak, H.　Bio Pharm Bull 　46　1133-1140　2023　関連リンク
Original article, 　Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of in silico Liver-to-Plasma Partition Coefficients. 　Adachi K, Utsumi M, Sato T, Nakano H, Shimizu M, and Yamazaki H. 　Bio Pharm Bull　46　1316-1323　2023　関連リンク
Original article, 　A decreasing plasma concentration of a toxicologically active metabolite 9-carboxymethoxymethylguanine after dialysis – a potential new clinical biomarker for improving encephalopathy in patients treated with acyclovir. 　Unita R, Adachi K, Inada A, Shimizu M, Beppu S, Yamazaki H.　J Infect Chemother　29　1068-1070　2023　関連リンク
Review,　US regulations to curb alleged cancer causes are ineffectual and compromised by scientific, constitutional and ethical violations. 　Gori, G. B., Aschner, M., Borgert, C. J., Cohen, S. M., Dietrich, D. R., Galli, C. L., Greim, H., Heslop?Harrison, J. S., Kacew, S., Kaminski, N. E., Klaunig, J. E., Marquardt, H. W. J., Pelkonen, O., Roberts, R., Savolainen, K. M., Tsatsakis·, A., and Yamazaki, H.　Archives of Toxicology　97　1813-1822　2023　関連リンク
Original article, 　2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A22. 　Uno, Y.; Morikuni, S.; Murayama, N.; Yamazaki, H. 　Xenobiotica　53　60-65　2023　関連リンク
Original article, 　Novel cytochrome P450 2C94 (CYP2C94) functionally metabolizes diclofenac and omeprazole in dogs.　Uno, Y., Morikuni, S., Shiraishi, M., Asano, A., Murayama, N., and Yamazaki, H. 　Drug Metab Dispos　51　637-644　2023　関連リンク
Original article, 　Newly Identified Tree Shrew Cytochrome P450 2A13 (CYP2A13) is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog CYP2A13 and Pig CYP2A19. 　Ushirozako, G., Noda, Y., Murayama, N., Kawaguchi, H., Tsukiyama-Kohara, K., Yamazaki, H., and Uno, Y. 　Drug Metab Dispos　51　610-617　2023　関連リンク
Original article, 　Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers. 　Uehara, S., Higuchi, Y., Yoneda, N., Kato, H., Yamazaki, H., and Suemizu, H.　Drug Metab Dispos　51　480-491　2023　関連リンク
Original article, 　Roles of human cytochrome P450 3A4/5 in dexamethasone 6beta-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin. 　Uehara, S., Shimizu, M., Suemizu, H., and Yamazaki, H. 　Drug Metab Pharmacokinet　49　100504　2023　
Original article, 　Newly identified cytochrome P450 3A genes of tree shrews and pigs are expressed and encode functional enzymes 　Uno, Y., Jikuya, S., Noda, Y., Oguchi, A., Murayama, N., Kawaguchi, H., Tsukiyama-Kohara, K., and Yamazaki, H. 　Comp Biochem Physiol C Toxicol Pharmacol　267　109579　2023　関連リンク
Original article, 　 A family study of compound variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found by urinary phenotyping for trimethylaminuria. 　Shimizu, M., Yamamoto, A., Makiguchi, M., Shimamura, E., Yokota, Y., Harano, M., and Yamazaki, H. 　Drug Metab Pharmacokinet　48　100490,　2023　関連リンク
Original article, 　Novel cytochrome P450 1 (CYP1) genes in tree shrews are expressed and encode functional drug-metabolizing enzymes　Uno, Y., Noda, Y., Murayama, N., Tsukiyama-Kohara, K., and Yamazaki, H.　Comp Biochem Physiol C　265　109534　2023　関連リンク
Original article, 　High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4*16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database. 　Adachi, K., Ohyama, K., Tanaka, Y., Sato, T., Murayama, N., Shimizu, M., Saito, Y., and Yamazaki, H. 　Drug Metab Pharmacokinet　49　100486,　2023　関連リンク
Review,　Species specificity and selection of models for drug oxidations mediated by polymorphic human enzymes. 　Yamazaki, H., and Shimizu, M. 　Drug Metab Dispos　51　123-129　2023　関連リンク
Original article, 　A Comprehensive Investigation of Dog Cytochromes P450 3A (CYP3A) Reveales A Functional Role of Newly Identified CYP3A98 in Small Intestine　Uno, Y., Jikuya, S., Noda, Y., Murayama, N., and Yamazaki, H. 　Drug Metab Dispos　51　38-45　2023　関連リンク
Original article, 　A comprehensive analysis of six forms of cytochrome P450 2C (CYP2C) in pigs. 　Uno, Y., Morikuni, S., Shiraishi, M., Asano, A., Kawaguchi, H., Murayama, N., and Yamazaki, H. 　Xenobiotica　52　963-972　2022　関連リンク
Original article, 　Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolizing enzymes. 　Uno Y, Ushirozako G, Uehara S, Murayama N, Fujiki Y, Kawaguchi H, Tsukiyama-Kohara K, and Yamazaki H. 　Xenobiotica　52　687-696　2022　関連リンク
Original article, 　Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2　Kojima A, Nadai M, Murayamam N, Yamazaki H, Katoh M.　Xenobiotica　52　669-675　2022　関連リンク
Original article, 　Forward and Reverse Dosimetry for Aniline and 2,6-Dimethylaniline in Humans Extrapolated from Humanized-liver Mouse Data Using Simplified Physiologically Based Pharmacokinetic Models.　Miura, T., Uehara, S., Shimizu, M., Suemizu, H., and Yamazaki, H. 　J Toxicol Sci　47　531-538　2022　関連リンク
Original article, 　Updated in Silico Prediction Methods for Fractions Absorbed and Key Input Parameters of 355 Disparate Chemicals for Physiologically Based Pharmacokinetic Models for Time-Dependent Plasma Concentrations after Virtual Oral Doses in Humans. 　Adachi K, Shimizu M, Yamazaki H. 　Biol Pharm Bull　45　1812-1817　2022　関連リンク
Original article, 　Updated in Silico Prediction Methods for Fractions Absorbed and Absorption Rate Constants of 372 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models for Estimating Internal Concentrations in Rats　Adachi K, Shimizu M, and Yamazaki H. 　J Toxicol Sci　47　453-456　2022　関連リンク
Original article, 　Combined risk assessment of food-derived coumarin with in silico approaches. 　Yamada, T., Katsutani, N., Maruyama, T., Kawamura, T., Yamazaki, H., Murayama, N., Tong, W., Yamazoe, Y., and Hirose, A. 　Food Safety 　10　73-82　2022　関連リンク
Original article, 　Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism　Uehara S, Iida Y, Ida-Tanaka M, Goto M, Kawai K, Yamamoto M, Higuchi Y, Ito S, Takahashi R, Kamimura H, Ito M, Yamazaki H, Oshimura M, Kazuki Y, Suemizu H. 　Sci Rep　12　14907　2022　関連リンク
Original article, 　Correction to "An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats." 　Kamiya, Y., Handa, K., Miura, T., Ohori, J., Shimizu, M., Kitajima, M., Shono, F., Funatsu, K., and Yamazaki, H　Chem Res Toxicol　35　1433　2022　関連リンク
Original article, 　市販の鎮痛薬を過量摂取し急性カフェイン中毒を来した14歳女児　神野太郎、進藤淳也、相澤魁人、西田光宏、清水万紀子、山崎浩史、上牧務　小児科臨床　754　275-280　2022　
Original article, 　Further survey of genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found in an updated database of genome resources and identified by phenotyping for trimethylaminuria.　Shimizu, M., Hirose, N., Kato, M., Sango, H., Uenuma, Y., Makiguchi, M., Hishinuma, E., Saito, S., Hiratsuka, M., and Yamazaki, H.　Drug Metab Pharmacokinet　46　100465　2022　関連リンク
Original article, 　Low cerebrospinal fluid-to-plasma ratios of orally administered lenalidomide mediated by its low cell membrane permeability in patients with hematologic malignancies. 　Ogiya D, Murayama N, Kamiya Y, Saito R, Shiraiwa S, Suzuki R, Machida S, Tazume K, Ando K, Yamazaki H.　Ann Hematol　101　2013-2019　2022　関連リンク
Original article, 　Molecular and functional characterization of N-acetyltransferases in common marmosets and pigs　Uno, Y., Uehara, S., Ijiri, M., Kawaguchi, H., Asano, A., Shiraishi, M., Banju, K., Murayama, N., and Yamazaki, H　Drug Metab Dispos　50　1429-1433　2022　関連リンク
Original article, 　Plasma and synovial fluid concentrations of linezolid in patients with knee osteoarthritis infected with Staphylococcus aureus. 　Negishi, D., Mitsumatsu, O., Matsumura, T., Mitsumatsu, H., Makiguchi, M., Shimizu, M., and Yamazaki, H. 　J Pharm Health Care Sci　8　16　2022　関連リンク
Original article, 　Molecular and functional characterization of flavin-containing monooxygenases in pigs, dogs, and cats.　Uno, Y., Shimizu, M., Ogawa, Y., Makiguchi, M., Kawaguchi, H., Yamato, O., Ishizuka, M., and Yamazaki, H. 　Biochem Pharmacol　202　115125　2022　関連リンク
Original article, 　Cytochrome P450 2J (CYP2J) Genes in Dogs, Cats, and Pigs Are Expressed and Encode Functional Drug-Metabolizing Enzymes. 　Uno Y, Murayama N, Ijiri M, Kawaguchfi H, Yamato O, Shiraishi M, Asano A, Teraoka H, Mizukawa H, Nakayamae SMM, Ikenaka Y, Ishizuka M, and Yamazaki H.　Drug Metab Dispos　50　1434-1441　2022　関連リンク
Original article, 　Trivariate Linear Regression and Machine Learning Prediction of Possible Roles of Efflux Transporters in Estimated Intestinal Permeability Values of 301 Disparate Chemicals　Shimizu M, Hayasaka R, Kamiya Y, and Yamazaki H. 　Biol Pharm Bull　45　1142-1157　2022　関連リンク
Review　Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans　Uno, Y., Uehara, S., and Yamazaki, H. 　Biochem Pharmacol　197　114887 　2022　関連リンク
Original article, 　Uehara S, Murayama N, Higuchi Y, Yoneda N, Yamazaki H, and Suemizu H.　Comparison of mouse and human cytochrome P450 mediated-drug metabolizing activities in hepatic and extrahepatic microsomes.　Xenobiotica　52　229-239　2022　関連リンク
Original article, 　Shimada T, Nagayoshi H, Murayama N, Sawai A, Kim V, Kim D, Yamazaki H, Guengerich FP, and Takenaka S.　 Oxidation of 3?-methoxyflavone, 4?-methoxyflavone, and 3?,4?-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13.　Xenobiotica　52　134-145　2022　関連リンク
Original article, 　Uehara, S., Yoneda, N., Higuchi, Y., Yamazaki, H., and Suemizu, H.　Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers. 　Drug Metab Pharmacokinet　44　100454　2022　関連リンク
Original article, 　Uehara, S., Shimizu, M., Plé, K., Routier, S., Yoneda, N., Higuchi, Y., Suemizu, H., and Yamazaki, H. 　Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo. 　Drug Metab Pharmacokinet,　44,　100453　2022　関連リンク
Original article, 　安達昂一郎、別府賢、清水万紀子、福田利明、山崎浩史　救急搬送事例となった企図的過量服用医薬品等の適正投与時の生理学的薬物動態モデルを用いた血中薬物動態再現の基盤研究　中毒研究　35　179-185　2022　
Original article, 　Plasma concentration profiles for hepatotoxic pyrrolizidine alkaloid senkirkine in humans extrapolated from rat data sets using a simplified physiologically based pharmacokinetic model　Kamiya, Y., Miura, T., Kato, A., Murayama, N., Shimizu, M., and Yamazaki, H.　Drug Metab Bioanal Lett,　15　64-69　2022　
White paper, 　Imaging Mass Spectrometry (IMS) for Drug Discovery and Development Survey: Results on Methods, Applications and Regulatory Compliance　Solon E, Groseclose MR, Ho S, Tanaka K, Nakada N, Linehan S, Nishidate M, Yokoi H, Kaji H, Urasaki Y, Watanabe K, Ishida T, Komatsu R, Yoshida K, Yamazaki H, Saito K, Saito Y, and Tanaka Y. 　Drug Metab Pharmacokinet　43　100438　2022　関連リンク
Original article, 　Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals　Kamiya, Y., Handa, K., Miura, T., Ohori, J., Kato, A., Shimizu, M., Kitajima, M., and Yamazaki, H. 　Biol Pharm Bull　45　124-128　2022　関連リンク
Original article, 　An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals. 　Uehara, S., Higuchi, Y., Yoneda, N., Kawai, K., Yamamoto, M., Kamimura, H., Iida, Y., Oshimura, M., Kazuki, Y., Yamazaki, H., Hikita, H., Takehara, T., and Suemizu, H. 　Drug Metab Pharmacokinet　42　100410　2022　関連リンク
Original article, 　Systematic identification and characterization of cynomolgus macaque solute carrier transporters　Uno Y, Yamazaki H.　Drug Metab Pharmacokinet 　43　100437　2022.　関連リンク
Review　Meet the Editorial Board Member　Yamazaki, H. 　Drug Metab. Lett.,　14　95-96　2021　
Review　Meet the Associate Editor　Hiroshi Yamazaki　Curr.Drug Metab　22　997　2021　
Original article, 　Pharmacokinetics of primary metabolites 5-hydroxythalidomide and 5?-hydroxythalidomide formed after oral administration of thalidomide in the rabbit, a thalidomide-sensitive species 　Kuwagata, M., Hasegawa, T., Takashima, H., Shimizu, M., Kitajima, S. and Yamazaki, H. 　J Toxicol Sci, 　46　553-560　2021　関連リンク
Original article, 　 A series of simple detection systems for genetic variants of flavin-containing monooxygenase 3 (FMO3) with impaired function in Japanese subjects. 　Shimizu M, Mizugaki A, Koibuchi N, Sango H, Uenuma Y, Yamazaki H.　Drug Metab Pharmacokinet　41　100420　2021　関連リンク
Original article, 　 Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice. 　Miura T, Uehara S, Shimizu M, Murayama N, Suemizu H, Yamazaki H.　J Toxicol Sci　46　525-530　2021　関連リンク
Original article, 　Pharmacokinetics of loxoprofen in a self-administered overdose in a Japanese patient admitted to hospital.　Adachi, K., Sugitani, Y., Unita, R., Yoshida, K., Beppu, S., Terashima, M., Fujii, M., Shimizu, M., and Yamazaki, H. 　J Pharm Health Care Sci　7　33　2021　関連リンク
Original article, 　Differences in pharmacokinetics and haematotoxicities of aniline and its dimethyl derivatives orally administered in rats.　Miura, T., Kamiya, Y., Murayama, N., Shimizu, M., and Yamazaki, H. 　Biol. Pharm. Bull　44　1775-1780　2021　関連リンク
Original article, 　Pharmacokinetics of caffeine self-administered in overdose in a Japanese patient admitted to hospital　Adachi, K., Beppu, S., Terashima, M., Fukuda, T., Tomizawa, J., Shimizu, M., and Yamazaki, H. 　J Pharm Health Care Sci, 　7　36　2021　関連リンク
Original article, 　Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes. 　Uehara, S., Yoneda, N., Higuchi, Y., Yamazaki, H., and Suemizu, H. 　Drug Metab Pharmacokinet　41　100419　2021　関連リンク
Original article, 　UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised livers. 　Uehara S, Higuchi Y, Yoneda N, Yamazaki H, Suemizu H. 　Xenobiotica　51　1146-1154　2021　関連リンク
Original article, 　Prediction of permeability across intestinal cell monolayers for 219 disparate chemicals using in vitro experimental coefficients in a pH gradient system and in silico analyses by trivariate linear regressions and machine learning　Kamiya, Y., Omura, A., Hayasaka, R., Saito, R., Sano, I., Handa, K., Ohori, J., Kitajima, M., Shono, F., Funatsu, K., and Yamazaki, H.　Biochem Pharmacol　192　114749　2021　
Original article, 　Pharmacokinetic modeling of over-the-counter drug diphenhydramine self-administered in overdoses in Japanese patients admitted to hospital　Adachi, K., Beppu, S., Terashima, M., Kobari, W., Shimizu, M., and Yamazaki, H. . 　Journal of Pharmaceutical Health Care and Sciences　7　32　2021　
Original article, 　Roles of cytochrome P450 2A6 in the oxidation of flavone, 4?-hydroxyflavone, and 4?-, 3?-, and 2?-methoxyflavones by human liver microsomes. 　Nagayoshi, H., Murayama, N., Takenaka, S., Kim, V., Kim, D., Komori, M., Yamazaki, H., Guengerich, F. P., and Shimada, T.　Xenobiotica　51　995-1009　2021　関連リンク
Original article, 　Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat in vivo and in vitro data sets using a simplified physiologically based pharmacokinetic model 　Yanagi M, Kamiya Y, Murayama N, Banju K, Shimizu M, Yamazaki H. 　J Toxicol Sci 　46　391-399　2021　
Original article, 　Different substrate elimination rates of model drugs pH-dependently mediated by flavin-containing monooxygenases and cytochromes P450 in human liver microsomes. 　Taniguchi-Takizawa, T., Kato, N., Shimizu, M., Kume, T., and Yamazaki, H. 　Drug Metab Pharmacokinet　40　100412 　2021　
Original article, 　Metabolic activation and deactivation of dietary-derived coumarin mediated by cytochrome P450 enzymes in rat and human liver preparations. 　Murayama, N. and Yamazaki, H. 　J Toxicol Sci　46　371-378　2021　
Original article, 　 Differences in hydrolase activities in the liver and small intestine between marmosets and humans. 　Honda, S., Fukami, T., Hirosawa, K., Tsujiguchi, T., Zhang, Y., Nakano, M., Uehara, S., Uno, Y., Yamazaki, H., and Nakajima, M.　Drug Metab Dispos,　49　718-728　2021　
Original article, 　Effects of polymorphic cytochrome P450 2A6 genotypes on chemoprevention against colorectal tumors in single Japanese cohort using daily low-dose aspirin: Insights into future personalized treatments. 　Yamazaki, H., Shimizu, M., Otani, T., Mizugaki, A., Mure, K., Suzuki, S., and Ishikawa, H. 　J Pharm Health Care Sci　 7　26　2021　
Original article, 　Pharmacokinetics of Primary Oxidative Metabolites of Thalidomide in Rats and in Chimeric Mice Humanized with Different Human Hepatocytes. 　Miura, T., Uehara, S., Shimizu, M., Suemizu, H., and Yamazaki, H. 　J Toxicol Sci　46　311-317　2021　
Original article, 　Cloning, sequence analysis, and tissue expression of marmoset paraoxonase 1. 　Uehara, S., Uno, Y., Shimizu, M., and Yamazaki, H.　Drug Metab Pharmacokinet　39　100398　2021　
Original article, 　Feasibility of physiologically based pharmacokinetic simulations for assessing pediatric patients after accidental drug ingestion: A case study of a 1.4-year-old girl who ingested alprazolam. 　Emoto, C., Shimizu, M., Tanaka, T., and Yamazaki, H. 　Drug Metab Pharmacokinet 　39　100394　2021　
Original article, 　Miura, T., Kamiya, Y., Uehara, S., Murayama, N., Shimizu, M., Suemizu, H., and Yamazaki, H. Hepatotoxicological potential of p-toluic acid in humanized-liver mice investigated using simplified physiologically based pharmacokinetic models　Shimizu, M., Koibuchi, N., Mizugaki, A., Hishinuma, E., Saito, S., Hiratsuka, M., and Yamazaki, H. 　Xenobiotica　51　636-642　2021　
Original article, 　海産魚摂取後の強い体臭から診断に至ったトリメチルアミン尿症（魚臭症）男児　小川真司、小川恵美、清水万紀子、山崎浩史　小児科臨床　74　433-438　2021　
Original article, 　トリメチルアミン尿症の女児例　蓮見純平、山崎浩史　日本小児科学会雑誌　125　467-471　2021　
Original article, 　Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources　Shimizu, M., Koibuchi, N., Mizugaki, A., Hishinuma, E., Saito, S., Hiratsuka, M., and Yamazaki, H. 　Drug Metab Pharmacokinet　38　100387　2021　
Original article, 　Teicoplanin physiologically-based pharmacokinetic modeling offers a quantitative assessment of a theoretical influence of serum albumin and renal function on its disposition　Emoto, C., Johnson, T. N., Yamada, T., Yamazaki, H., and Fukuda, T. 　Eur J Clin Pharmacol.　77　1157-1168　2021　
Original article, 　Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes　Uehara S, Yoneda N, Higuchi Y, Yamazaki H, Suemizu H. 　Xenobiotica　51　582-589　2021　
Original article, 　Genetic Variants of Aldehyde Oxidase (AOX) 1 in Cynomolgus and Rhesus Macaque　Uno Y, Uehara S, Murayama N, Yamazaki H. 　Xenobiotica　39　100398　2021　
Original article, 　Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19　Matsumoto, S., Uehara, S., Kamimura, H., Ikeda, H., Maeda, S., Hattori, M., Nishiwaki, M., Kato, K., and Yamazaki, H. 　Xenobiotica　51　479-493　2021　
Original article, 　Predicted Contributions of Flavin-containing Monooxygenases to the N-Oxygenation of Drug Candidates Based on their Estimated Base Dissociation Constants　Taniguchi-Takizawa, T., Kato, H., Shimizu, M., and Yamazaki, H. 　Curr Drug Metab,　22　208-214　2021　
Original article, 　In silico Prediction of input parameters for simplified physiologically based pharmacokinetic models for estimating plasma, liver, and kidney exposures in rats after oral doses of 246 disparate chemicals　Kamiya, Y., Handa, K., Miura, T., Yanagi, M., Shigeta, K., Hina , S., Shimizu, M., Kitajima, M., Shono, F., Funatsu, K., and Yamazaki, H. 　Chem Res Toxicol,　34　507-513　2021　
Original article, 　Pharmacokinetics of duloxetine self-administered in overdose with quetiapine and other antipsychotic drugs in a Japanese patient admitted to hospital　Adachi K, Beppu S, Nishiyama K, Shimizu M, and Yamazaki H. 　 J Pharm Health Care Sci.　7　6 　2021　
Original article, 　Uno, Y., Mikami, T., Tsukazaki, Y., Nakanishi, Y., Murayama, N., Ikushiro, S., Tsusaki, H., and Yamazaki, H. 　Genetic variants of UDP-glucuronosyltransferases 1A1, 1A6, and 1A9 in cynomolgus and rhesus macaques. 　Xenobiotica 　51　115-121　2021　
Original article, 　Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2?-, 3?-, 4?-, and 6-hydroxyflavanones by human cytochrome P450 enzymes. 　Shimada, T., Nagayoshi, H., Murayama, N., Takenaka, S., Katahira, J., Kim, V., Kim, D., Komori, M., Yamazaki, H., and Guengerich, F. P.　Xenobiotica　51　139-154　2021　
Original article, 　Evaluation of domain of unknown function 1220 (DUF1220) for detection of human genome by quantitative polymerase chain reaction: Potential use in assessing the biodistribution of transplanted therapeutic human cells. 　Okawa, Y., Kohara, S., Uchiyama, A., Yamazaki, H., and Uno, Y.　Drug Metab Pharmacokinet　38　100366　2021　
Original article, 　In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice.　Shimizu, M., Uehara, S., Suemizu, H., and Yamazaki, H.　 Drug Metab Pharmacokinet　37　100369　2021　
Original article, 　Plasma and Hepatic Concentrations of Acetaminophen and Its Primary Conjugates after Oral Administrations Determined in Experimental Animals and Humans and Extrapolated by Pharmacokinetic Modeling. 　Toda, A., Shimizu, M., Uehara, S., Sasaki, T., Miura, T., Mogi, M., Utoh, M., Suemizu, H., and Yamazaki, H. 　Xenobiotica　51　316-323　2021　
Original article, 　Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model　Miura, T., Uehara, S., Shigeta, K., Yoshizawa, M., Kamiya, Y., Murayama, N., Shimizu, M., Suemizu, H., and Yamazaki, H.　Chem. Res. Toxicol.　34　522-528　2021　
Original article, 　Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential　Miura, T., Shimizu, M., Uehara, S., Yoshizawa, M., Nakano, A., Yanagi, M., Kamiya, Y., Murayama, N., Suemizu, H., and Yamazaki, H　Chem Res Toxicol. 　33　3048-3053　2020　
Original article, 　Different effects of polymorphic flavin-containing monooxygenase 3 and cytochrome P450 2A6 activities on an index of arteriosclerosis as a lifestyle-related disease in a general population in Japan. 　Uraoka, M., Shimizu, M., Kuwajima, Y., Mizugaki, A., Yokoyama, H., Mure, K., and Yamazaki, H. 　Curr Drug Metab　21　161-1164　2020　
Original article, 　Molecular cloning and tissue distribution of marmoset thiopurine S-methyltransferase. 　Uehara, S., Uno, Y., and Yamazaki, H.　Drug Metab Pharmacokinet,　35　475-478　2020　
Original article, 　Molecular cloning, sequence analysis, and tissue distribution of marmoset monoamine oxidases A and B. 　Uehara, S., Uno, Y., and Yamazaki, H　Drug Metab Pharmacokinet.　35　479-482　2020　
Original article, 　Modelled plasma concentrations of pemafibrate with co-administered typical cytochrome P450 inhibitors clopidogrel, fluconazole, or clarithromycin predicted by physiologically based pharmacokinetic modelling in virtual populations.　Ogawa S, Shimizu M, Yamazaki H. 　Xenobiotica,　50　1413-1422　2020　
Original article, 　 Human plasma concentration-time profiles of troglitazone and troglitazone sulfate simulated by in vivo experiments with chimeric mice with humanized livers and semi-physiological pharmacokinetic modeling. 　Ito, S., Kamimura, H., Yamamoto, Y., Chijiwaa, H., Okuzonoa, T., Suemizu, H., and Yamazaki, H.　Drug Metab and Pharmacokinet,　35　505-514　2020　
Original article, 　Trimethylamine N-oxygenation in cynomolgus macaques genotyped for flavin-containing monooxygenase 3 (FMO3). 　Shimizu M, Uno Y, Utoh M, and Yamazaki H. 　Drug Metab Pharmacokinet,　35　571-573　2020　
Original article, 　Pharmacokinetics of anticoagulant edoxaban in overdose in a Japanese patient transported to hospital. J　Adachi, K., Tuchiya, J., Beppu, S., Nishiyama, K., Shimizu, M., and Yamazaki, H. 　J Pharm Health Care Sci 6, 　　20　2020　
Original article, 　Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model　Miura T, Kamiya Y, Hina S, Kobayashi Y, Murayama N, Shimizu M, Yamazaki H　J Toxicol Sci　45　695-700　2020　
Original article, 　Plasma, liver, and kidney exposures in rats after oral doses of industrial chemicals predicted using physiologically based pharmacokinetic models: A case study of per?uorooctane sulfonic acid　Kamiya Y, Yanagi M, Hina S, Shigeta K, Miura T, Yamazaki H. 　J Toxicol Sci　45　763-767　2020　
Original article, 　Physiologically based pharmacokinetic models redicting renal and hepatic concentrations of industrial chemicals after virtual oral doses in rats.　Kamiya, Y., Otsuka, S., Miura, T., Yoshizawa, M., Nakano, A., Iwasaki, M., Kobayashi, Y., Shimizu, M., Kitajima, M., Shono, F., Funatsu, K., and Yamazaki, H　Chem Res Toxicol.　33 　1736-1751　2020　関連リンク
Original article, 　Novel variants in outer protein surface of flavin-containing monooxygenase 3 found in an Argentinian case with impaired capacity for trimethylamine N-oxygenation　Dionisio L, Shimizu M, Stupniki S, Oyama S, Aztiria E, Alda M, Yamazaki H, and Spitzmaul G 　Drug Metab. Pharmacokinet. 　35　383-388　2020　
Original article, 　Regional distributions of UDP-glucuronosyltransferase activities toward estradiol and serotonin in the liver and small intestine of cynomolgus macaques.　Nakanishi Y, Uno Y, Yamazaki H.　Drug Metab. Pharmacokinet. 　35　401-404　2020　
Original article, 　Human Aldehyde Oxidase 1-mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes. 　Uehara S, Yoneda N, Higuchi Y, Yamazaki H, Suemizu H.　Drug Metab Dispos 　48　580--586　2020　
Original article, 　Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.　Nakayama K, Kamimura H, Suemizu H, Yoneda N, Nishiwaki M, Iwamoto K, Mizunaga M, Negoro T, Ito S, Yamazaki H, and Nomura Y. 　Drug Metab. Pharmacokinet. 　35　389-396　2020　
Original article, 　 Increased plasma concentrations of an antidyslipidemic drug pemafibrate co-administered with rifampicin or cyclosporine A in cynomolgus monkeys genotyped for the organic anion transporting polypeptide 1B1. Drug Metab and Pharmacokinet　Ogawa S-i, Shimizu M, Kamiya Y, Uehara S, Suemizu H, and Yamazaki H 　Drug Metab. Pharmacokinet. 　35　354-360　2020　
Original article, 　 Genetic variants of N-acetyltransferases 1 and 2 (NAT1 and NAT2) in cynomolgus and rhesus macaques　Uno, Y., Murayama, N., and Yamazaki, H.　Biochem Pharmacol　174　113996　2020　
Original article, 　Preference for O-demethylation reactions in the oxidation of 2 -, 3 -, and 4 -methoxyflavones by human cytochrome P450 enzymes　Nagayoshi, H., Murayama, N., Tsujino, M., Takenaka, S., Katahira, J., Kim, V., Kim, D., Komori, M., Yamazaki, H., Guengerich, F. P., and Shimada　Xenobiotica　50　1158–1169　2020　
Original article, 　Different roles of human cytochrome P450 2C9 and 3A enzymes in diclofenac 4'- and 5-hydroxylations mediated by metabolically inactivated human hepatocytes in previously transplanted chimeric mice. 　Miura, T., Uehara, S., Shimizu, M., Murayama, N., Utoh, M., Suemizu, H., and Yamazaki, H. 　Chem. Res. Toxicol.　33 　634-639　2020　関連リンク
Original article, 　Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment　Ogawa, S., Shimizu, M., and Yamazaki, H. 　Xenobiotica　50　1023-1031　2020　
Original article, 　mRNA levels of drug-metabolizing enzymes in 11 brain regions of cynomolgus macaques　Uno, Y. and Yamazaki, H.　Drug Metab. Pharmacokinet. 　35　248-252　2020　
Original article, 　Molecular characterization of functional UDP-glucuronosyltransferases 1A and 2B in common marmosets. 　Uno, Y., Uehara, S., Inoue, T., Kawamura, Y., Murayama, N., Nishikawa, M., Ikushiro, S., Sasaki, E., and Yamazaki, H. 　Biochem. Pharmacol.　172　113748　2020　
Review, 　The marmoset cytochrome P450 superfamily: sequence/phylogenetic analyses, genomic structure, and catalytic function　Uehara S., Uno Y. and Yamazaki H. 　Biochem.Pharmacol.　171　113721　2020　関連リンク
Original article, 　Prediction of circulating human metabolites of pemafibrate, a novel antidyslipidemic drug, using chimeric mice with humanized liver. 　Ogawa S, Uehara S, Tsunenari Y, Kawai H, Suemizu H and Yamazaki H. 　Xenobiotica　50　769-775　2020　
Original article, 　Cloning and tissue expression of cytochrome P450 2S1, 4V2, 7A1, 7B1, 8B1, 24A1, 26A1, 26C1, 27A1, 39A1, and 51A1 in marmosets. 　Uehara S, Uno Y, Inoue T, Sasaki E and Yamazaki H. 　Drug Metab, Pharmacokinet.　35　244-247　2020　
Original article, 　Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes　Uehara, S., Yoneda, N., Higuchi, Y., Yamazaki, H., and Suemizu, H. 　Xenobiotica　50　733-740　2020　
Original article, 　Expression levels of microRNAs that are potential cytochrome P450 regulators in cynomolgus macaques　Uno Y. and Yamazaki H. 　Xenobiotica　50　747-752　2020　
Original article, 　Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver　Sawada T, Yamamura Y, Higuchi S, Imawaka H, Yamazaki H.　Xenobiotica　50　526-535　2020　
Original article, 　Simple pharmacokinetic models accounting for drug monitoring results of atomoxetine and its 4-hydroxylated metabolites in Japanese pediatric patients genotyped for cytochrome P450 2D6. 　Notsu, Y., Shimizu, M., Sasaki, T., Nakano, A., Ota, M., Yoshida, S., and Yamazaki, H. 　Drug Metab. Pharmacokinet.　35　191-200　2020　
Original article, 　Adult and infant pharmacokinetic profiling of dihydrocodeine using physiologically based pharmacokinetic modeling. 　Ota, M., Shimizu, M., Kamiya, Y., Emoto, C., Fukuda, T., and Yamazaki, H.　Biopharm. Drug Dispos.　40　350－357　2019　
Review, 　Hepatic concentrations of industrial chemicals extrapolated using pharmacokinetic models for predicting liver toxicity. 　Yamazaki, H., Kamiya Y. 　Toxicol Res.　35　 295-301　2019　
Original article, 　Genetic variants of flavin-containing monooxygenase 3 (FMO3) derived from Japanese subjects with the trimethylaminuria phenotype and whole-genome sequence data from a large Japanese database. 　Shimizu, M., Yoda, H., Nakakuku, K., Saso, A., Saito, I., Hishinuma, E., Saito, S., Hiratsuka, M., and Yamazaki, H. 　Drug Metab. Pharmacokinet. 　34　334－339334－339　2019　
Original article, 　Human plasma and liver concentrations of styrene estimated by combining a simple physiologically based pharmacokinetic model with rodent data　Miura, T., Uehara, S., Nakazato, M., Kusama, T., Toda, A., Kamiya, Y., Murayama, N., Shimizu, M., Suemizu, H., and Yamazaki, H. 　J. Toxicol.l Sci.,　44　543-548　2019　
Original article, 　Molecular and functional characterization of cytosolic sulfotransferases in cynomolgus macaque　Uno, Y., Murayama, N., and Yamazaki, H. 　Biochem. Pharmacol.　166　153-162　2019　
Original article, 　Oxidation of flavone, 5-hydroxyflavone, and 5,7-dihydroxyflavone to mono-, di-, and tri-hydroxyflavones by human cytochrome P450 enzymes. 　Nagayoshi, H., Murayama, N., Kakimoto, K., Tsujino, M., Takenaka, S., Katahira, J., Lim, Y.-R., Kim, D., Yamazaki, H., Komori, M., Guengerich, F. P, and Shimada, T. 　Chem. Res. Toxicol.　32　1268-1280　2019　
Original article, 　Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: potent inhibition by azelnidipine and manidipine. 　Ikemura, N., Yamaori, S., Kobayashi, C., Kamijo, S., Murayama, N., Yamazaki, H., and Ohmori, S.　Chem.-Biol. Inter.,　306　1-6　2019　
Review, 　Message from the President of the Japanese Society for the Study of Xenobiotics (in Japanese)　Yamazaki, H.　Yakugaku Zasshi　139　415-417　2019　
Original article, 　Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques　Uno, Y., Takahira, R., Murayama, N., Onozeki, S., Kawamura, S., Uehara, S., Ikenaka, Y., Ishizuka, M., Ikushiro, S., and Yamazaki, H.　Biochem. Pharmacol.　163　335－344　2019　
Original article, 　Steady-state human pharmacokinetics of monobutyl phthalate predicted by physiologically based pharmacokinetic modeling using single-dose data from humanized-liver mice orally administered with dibutyl phthalate　Miura, T., Uehara, S., Mizuno, S., Yoshizawa, M., Murayama, N., Kamiya, Y., Shimizu, M., Suemizu, H., and Yamazaki, H.　Chem. Res. Toxicol.　33　333-340　2019　
Review, 　Editorial　Aschner, M., Autrup, H.N., Cohen, S.M., Dekant, W., Eisenbrand, G., Galli, C.L., Gori, G.B., Kaminski, N.E., Klaassen, C.D., Klaunig, J.E., Levy, L., Lotti, M., Marquardt, H.W., Pelkonen, O., Schrenk, D.F., and Yamazaki, H. 　 Regul.Toxicol.Pharmacol.　101　A1-A2　2019　
Original article, 　Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6　Uehara, S., Murayama, N., Yamazaki, H., and Suemizu, H.　Xenobiotica　49　1321-1331　2019　
Original article, 　Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver　Iwata, H., Goto, M., Sakai, N., Suemizu, H., and Yamazaki, H. 　Xenobiotica　49　1311-1322　2019　
Original article, 　Plasma and hepatic concentrations of chemicals after virtual oral administrations extrapolated using rat plasma data and simple physiologically based pharmacokinetic models. 　Kamiya, Y., Otsuka, S., Miura, T., Takaku, H., Yamada, R., Nakazato, M., Nakamura, H., Mizuno, S., Shono, F., Funatsu, K., and Yamazaki, H.　Chem. Res.Toxicol.　32　211-218　2019　
Original article, 　Pharmacokinetics and metabolism of pemafibrate, a novel selective peroxisome proliferator-activated receptor-alpha modulator, in rats and monkeys　Ogawa, S., Tunenari, Y., Kawai, H., and Yamazaki, H.　Biopharm. Drug Dispos.　40　12-17　2019　
Original article, 　Prediction of human distribution volumes of compounds in various elimination phases using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in animals. 　Shimizu, H., Yoshida, K., Nakada, T., Ogasawara, A., and Yamazaki, H. 　Drug Metab. Dispos. 　47　114-123　2019　
Original article, 　Novel variants and haplotypes of human flavin-containing monooxygenase 3 (FMO3) gene associated with Japanese subjects suffering from trimethylaminuria.　Shimizu, M., Yoda, H., Igarashi, N., Makino, M., Tokuyama, E., and Yamazaki, H. 　Xenobiotica　49　1244-1250　2019　
Original article, 　Functionally relevant genetic variants of glutathione S-transferase GSTM5 in cynomolgus and rhesus macaques　Yasuhiro Uno, Norie Murayama, Kazuaki Tamura, and Hiroshi Yamazaki　Xenobiotica　49　995-1000　2019　
Original article, 　Pharmacokinetics of anticoagulants apixaban, dabigatran, edoxaban and rivaroxaban in elderly Japanese patients with atrial fibrillation treated in one general hospital　Miho Yamazaki-Nishioka, Minoru Kogiku, Masayuki Noda, Sumio Endo, Mitsuru Takekawa, Hirohisa Kishi, Miki Ota, Yuki Notsu, Makiko Shimizu, and Hiroshi Yamazaki　Xenobiotica　49　1001-1006　2019　
Review, 　Survey of drug oxidation activities in hepatic and intestinal microsomes of individual common marmosets, a new nonhuman primate animal model. 　Uehara, S., Oshio, T., Nakanishi, K., Tomioka, E., Suzuki, M., Inoue, T., Uno, Y., Sasaki, E., and Yamazaki, H. 　Curr.Drug Metab. 　20　103-113　2019　
Original article, 　Non-synonymous genetic variants of flavin-containing monooxygenase 3 (FMO3) in cynomolgus macaques. 　Uno, Y., Shimizu, M., Yoda, H., Origuchi, Y., and Yamazaki, H.　Drug Metab. Pharmacokinet　34　104-107　2019　
Original article, 　Expression and metabolic activity of flavin-containing monooxygenase 1 (FMO1) in cynomolgus macaque kidney　Uno Y, Shimizu M, Yoda H, Yamazaki H.　J.Med.Primatol　48　51–53　2019　
Original article, 　In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions　Makino, C., Watanabe, A, Deguchi, T., Shiozawa, H., Scheck, I., Rozehnal, V., Ishizuka, T., Watanabe, N., Ando, O., Murayama, N., and Yamazaki, H. 　Xenobiotica　49　961－969　2019　
Original article, 　In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys, and humans　Koyanagi, T., Yano, K., Kim, S., Murayama, N., Yamazaki, H., and Tamai, I. 　Xenobiotica　49　887-894　2019　
Original article, 　Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes　Nagayoshi, H., Murayama, N., Kakimoto, K., Takenaka, S., Kitahara, J., Lim, Y.-R., Kim, V., Kim, D., Yamazaki, H., Komori, M., Guengerich, F. P., and Shimada, T. 　Xenobiotica　49　791-802　2019　
Original article, 　Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanized livers　Uehara, S., Higuchi, Y., Yoneda, N., Yamazaki, H., and Suemori, H. 　Xenobiotica　49　678-687　2019　
Original article, 　Suitable albumin concentrations for enhanced drug oxidation activities mediated by human liver microsomal cytochrome P450 2C9 and other forms predicted with unbound fractions and partition/distribution coefficients of model substrates　Shimura, K., Murayama, N., Tanaka, S., Onozeki, S., and Yamazaki, H. 　Xenobiotica　49　557-562　2019　
Original article, 　Human urinary concentrations of monoisononyl phthalate estimated using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in humanized-liver mice orally administered with diisononyl phthalate　Miura T, Suemizu H, Goto M, Sakai N, Iwata H, Shimizu M and Yamazaki H.　Xenobiotica　49　513-520　2019　
Original article, 　Marmoset cytochrome P450 2B6, a propofol hydroxylase expressed in liver　Oshio, T., Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.　Xenobiotica　3　265–269　2019　関連リンク
Review article,　Importance of cynomolgus monkeys in development of monoclonal antibody drugs.　Iwasaki K, Uno Y, Utoh M and Yamazaki H.　Drug Metab. Pharmacokinet.　34　55-62　2019　関連リンク
Original article, 　Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone　Kakimoto, K., Murayama, N., Takenaka, S., Nagayoshi, H., Lim, Y.-R., Kim, V., Kim, D., Yamazaki, H., Komori, M., Guengerich, F. P., and Shimada, T. 　Xenobiotica　49　131-142　2019　関連リンク
Original article, 　Cytochrome P450-dependent drug oxidation activities in commercially available hepatocytes derived from human induced pluripotent stem cells cultured for 3 weeks　Murayama, N. and Yamazaki, H.　J.Toxicol.Sci.　43　241-245　2018　
Original article, 　Improved intranasal retentivity and transnasal absorption enhancement by PEGylated poly-L-ornithine.　Kamiya, Y., Yamaki, T., Omori, S., Uchida, M., Ohtake, K., Kimura, M., Yamazaki, H., and Natsume, H. 　Pharmaceuticals,　11　9　2018　
Original article, 　Cytochrome P450 1A1, 2C9, 2C19, and 3A4 polymorphisms account for inter-individual variability of toxicological drug metabolism in cynomolgus macaques. 　Uno, Y., Uehara, S., Murayama, N., and Yamazaki, H. 　Chem. Res. Toxicol.　31　1373-1381　2018　
Original article, 　Molecular and functional characterization of N-acetyltransferases NAT1 and NAT2 in cynomolgus macaque　Uno, Y., Murayama, N., and Yamazaki, H. 　Chem. Res. Toxicol.　31　1269－1276　2018　
Original article, 　Genetic variants of glutathione S-transferase GSTT1 and GSTT2 in cynomolgus macaques: identification of GSTT substrates and functionally relevant alleles. 　Uno, Y., Murayama, N., Kato, M., Tanaka, S., Ohkoshi, T., and Yamazaki, H. 　Chem. Res. Toxicol.　31　1086－1091　2018　
Commentaly, 　Obfuscating Transparency? 　Marquardt,H.W.J., Autrup,H., Berry,C.L., Boobis,A.R., Cohen,S.M., Dekant,W., Galli,C.L., Goodman,J.I., Gori,G.B., Greim,H.A., Kaminski,N.E., Klaassen,C.D., Klaunig,J.E., Lotti,M., Marquardt,H.W.J., Moretto,A., Pelkonen,O., Sipes,I.G., Wallace,K.B., and Yamazaki,H. 　Regul. Toxicol. Pharmacol.　97　A1-A3　2018　
Original article, 　Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques. 　Uno, Y., Takahira, R., Murayama, N., Ishii, Y., Ikenaka, Y., Ishizuka, M., Yamazaki, H., and Ikushiro, S. 　Biochem. Pharmacol.,　155　172-181　2018　関連リンク
Original article, 　Collaborative method performance study of the measurement of nicotine, its metabolites, and total 3 nicotine equivalents in human urine　Wang L, Bernert JT, Benowitz NL, Feng.J., Jacob III P, McGaheea E, Caudilla SP, Scherer G, Scherer M, Pluym N, Doig MV, Newland K, Murphy SE, Caron NJ, Sander LC, Shimizu M, Yamazaki H, Kim S, Langman LJ, Pritchett JS, Sniegoski LT, Li Y, Blount BC, Pirkle JL. 　Cancer Epidemiol Biomarker Prev　27　1-8　2018　関連リンク
Original article, 　In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants　Nakanishi, K., Uehara, S., Kusama, T., Inoue, T., Shimura, K., Kamiya, Y., Murayama, N., Shimizu, M., Uno, Y., Sasaki, E., and Yamazaki, H　Biochem. Pharmacol.　152 　272-282　2018　関連リンク
Original article, 　Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver　Nakayama, K., Ito, S., Suzuki, M., Takubo, H., Yamazaki, H., and Nomura, Y　Xenobiotica　49　404-414　2018　関連リンク
Original article, 　Human plasma concentrations of trimethylamine N-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice　Shimizu, M., Suemizu, H., Mizuno, S., Kusama, T., Miura, T., Uehara, S., and Yamazaki, H.　J.Toxicol. Sci.　43　387-393　2018　
Original article, 　 Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity dete,cted by human serum albumin RNA. 　Murayama,N., Suemizu,H., Uehara,S., Kusama,T. Mitsui,M., Kamiya,Y., Shimizu,M., Guengerich,F. P., and Yamazaki,H.　J. Toxicol.Sci,　43　369-375　2018　
Original article, 　Polymorphisms of cytochrome P450 2B6 (CYP2B6) in cynomolgus and rhesus macaques　Uno, Y., Uehara, S., and Yamazaki, H. 　 J.Med.Primatol. 　47　232-237　2018　
Review article,　Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans　Uno, Y., Uehara, S., and Yamazaki, H. 　Biochem. Pharmacol.　153 　184-195　2018　関連リンク
Original article, 　Dihydrocodeine overdoses in a neonate and in a 14-year-old girl who were both genotyped as cytochrome P450 2D6*1/*10-*36: comparing developmental ages and drug monitoring data with the results of pharmacokinetic modeling　Shimizu, M. Kondo, T. Fukuoka, T. Tanaka, T. and Yamazaki, H.　Ther. Drug Monit.　40　162-165　2018　関連リンク
Original article, 　Chimeric mice with humanized liver as a model for testing organophosphate and carbamate pesticide exposure　Suemizu, H., Kawai, K., Murayama, N., Nakamura, M., and Yamazaki, H.　Pest Manag.Sci　74　1424-1430　2018　関連リンク
Original article, 　 In vivo analysis of the anti-atrial fibrillatory, proarrhythmic and cardiodepressive profiles of dronedarone as a guide for safety pharmacological evaluation of antiarrhythmic drugs. 　Motokawa, Y., Nakamura, Y., Hagiwara-Nagasawa, M., Goto, A., Chiba, K., Lubna, N. J., Izumi-Nakaseko, H., Ando, K., Naito, A. T. , Yamazaki, H., and Sugiyama, A.　Cardiovasc. Toxicol., 　18　242-251　2018　関連リンク
Original article, 　Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies　Murayama, N., Yajima, K., Hikawa, M., Shimura, K., Ishii, Y., Takada, M., Uno, Y., Utoh, M., Iwasaki, K., and Yamazaki, H. 　Biopharm. Drug Dispos.　39　115-121　2018　関連リンク
Original article, 　Association with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models　Kusama, T., Toda, A., Shimizu, M., Uehara, S., Inoue, T., Uno, Y., Utoh, M., Sasaki, E., and Yamazaki, H. 　Xenobiotica,　48　1072-1077　2018　関連リンク
Original article, 　Molecular cloning and tissue distribution of a novel marmoset ABC transporter　Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H. 　Biopharm. Drug Dispos.　39　59-63　2018　関連リンク
Original article,　Expression of cytochrome P450 regulators in cynomolgus macaque. 　Uno, Y. and Yamazaki, H. 　Xenobiotica　48　695-703　2018　関連リンク
Original article,　Progesterone hydroxylation by cytochromes P450 2C and 3A enzymes in marmoset liver microsomes. 　Nakanishi, K., Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H. 　Xenobiotica　48　757-763　2018　関連リンク
Original article,　Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol, and midazolam in common marmosets genotyped for cytochrome P450 2C19.　Toda, A., Uehara, S., Inoue, T., Utoh, M., Kusama, T., Shimizu, M., Uno, Y., Mogi, M., Sasaki, E., and Yamazaki, H. 　Xenobiotica　48　720-726　2018　関連リンク
Original article, 　Marmoset pulmonary cytochrome P450 2F1 oxidizes biphenyl and 7-ethoxycoumarin and hepatic human P450 substrates..　Uehara, S., Uno, Y., Oshio, T., Inoue, T., Sasaki, E., and Yamazaki, H　Xenobiotica　48　656-662　2018　関連リンク
Original article,　 Development of genotyping method for functionally relevant variants of cytochromes P450 in cynomolgus macaques.　Uno, Y., Osada, N., Sakurai, S., Shimozawa, N., Iwata, T., Ikeo, K., and Yamazaki, H.　J.Vet.Pharmacol.Ther.,　41　e30-e34　2018　関連リンク
Original article,　Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and ffve CYP2A13 allelic variants　Shimada, T., Murayama, N., Kakimoto, K., Takenaka, T., Lim, Y.-R., Yeom, S., Kim, D., Yamazaki, H., Guengerich, F. P., and Komori, M. 　Xenobiotica　48　565-575　2018　関連リンク
Original article,　Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines. 　Uehara, S., Yuki, Y., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.　Xenobiotica　48　342-347　2018　関連リンク
Original article,　R-Warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys　Utoh, M., Kusama, T., Miura, T., Mitsui, M., Kawano, M., Hirano, T., Shimizu, M., Uno, Y., and Yamazaki, H.　Xenobiotica　48　206-210　2018　関連リンク
Original article,　Human plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice　Yamazaki-Nishioka, M., Shimizu, M., Suemizu, H., Nishiwaki, M., Mitsui, M., and Yamazaki, H. 　Xenobiotica　48　117-123　2018　関連リンク
Review　Meet Our Editorial Board Member　Hiroshi Yamazaki　Drug Metabolism Letters　11　1　2017　
Review article,　Differences in toxicological and pharmacological responses mediated by polymorphic cytochromes P450 and related drug-metabolizing enzymes.　Yamazaki, H.　Chem. Res. Toxicol.　30　53-60　2017　関連リンク
Correction, 　Correction to “Molecular Cloning, Tissue Distribution, and Functional Characterization of Marmoset Cytochrome P450 1A1, 1A2, and 1B1”　Uehara S., Uno Y., Inoue T., Sasaki E., and Yamazaki H　Drug Metab.Dispos.　45　956　2017　
Corrigendum, 　Corrigendum to "Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9" [Drug Metab Pharmacokinet 30 (2015) 130-132]　Uno, Y., Matsushita, A., Murayama, N., and Yamazaki, H. 　Drug Metab.Pharmacokinet.,　32　192　2017　
Original article,　The dihydroxy metabolite of the teratogen thalidomide causes oxidative DNA damage　Wani, T. H., Chakrabarty, A., Shibata, N., Yamazaki, H., Guengerich, F. P., and Chowdhury, G. 　Chem. Res. Toxicol.　30　1622-1628　2017　
Original article,　Effects of meat intake frequency and polymorphic cytochrome P450 2A6 activity on individual colorectal tumour risk in a Japanese cohort.　Yamazaki, H., Fujieda, M., Shimizu, M., Shiotani, A., SImabukuro, S., Mure, K., Takeshita, H., and Ishikawa, H. 　J.Cancer Ther.　8　645－652　2017　関連リンク
Original article,　Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models　Utoh, M., Miura, T., Kusama, T., Uehara, S., Shimizu, M., Uno, Y., and Yamazaki, H.　Biopharm. Drug Dispos.,　38　439-442　2017　関連リンク
Original article,　Hepatic expression of cytochrome P450 enzymes in non-human primate species. 　Uehara, S., Uno, Y., and Yamazaki, H. 　J.Med.Primatol.　46　347-351　2017　関連リンク
Original article,　Regio- and stereo-selective oxidation of a cardiovascular drug metoprolol mediated by cytochrome P450 2D and 3A enzymes in marmoset livers　Uehara, S., Ishii, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H　Drug Metab. Dispos.,　45　896-899　2017　関連リンク
Original article,　Molecular cloning and characterization of marmoset aldehyde oxidase　Uehara, S., Uno, Y., Okamoto, E., Inoue, T., Sasaki, E., and Yamazaki, H. 　Drug Metab. Dispos　45　883-886　2017　関連リンク
Original article,　Human plasma and urinary metabolic profiles of trimethylamine and trimethylamine N-oxide extrapolated using a simple physiologically based pharmacokinetic model　Shimizu, M. and Yamazaki, H. 　J.Toxicol. Sci.　42　485-490　2017　
Original article,　Functional characterization and tissue expression of marmoset cytochrome P450 2E1 　Uehara, S., Uno, Y., Tomioka, E., Inoue, T., Sasaki, E., and Yamazaki, H. 　Biopharm. Drug Dispos.,　38　394-397　2017　
Original article,　Ratio of serum levels of AGEs to soluble RAGE Is correlated with trimethylamine-N-oxide in non-diabetic subjects.　Tahara, N., Yamagishi, S., Tahara, A., Honda, A., Igata, S., Bekki, M., Nakamura, T., Sugiyama, Y., Takeuchi, M., Shimizu, M., Yamazaki, H., Fukami, K., and Fukumoto, Y. 　 Int.J.Food Sci.Nutr.　68　013-1020　2017　関連リンク
Original article,　Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity.　Murayama, N., Kazuki, Y., Satoh, D., Arata, K., Harada, T., Shibata, N., Guengerich, F. P., and Yamazaki, H.　J. Toxicol. Sci.　42　343-348　2017　関連リンク
Original article,　Marmoset flavin-containing monooxygenase 3 in liver is a major benzydamine and sulindac sulfide oxygenase. 　Uehara, S., Shiimizu, M., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.　Drug Metab. Dispos.　45　497-500,　2017　関連リンク
Original article,　Marmoset cytochrome P450 3A4 orthologue expressed in liver and small intestine tissues efficiently metabolizes midazolam, alprazolam, nifedipine, and testosterone　Uehara, S., Uno, Y., Nakanishi, K., Ishii, S., Inoue, T., Sasaki, E., and Yamazaki, H. 　Drug Metab.Dispos.　45　457-467　2017　関連リンク
Original article,　Characterization of microminipig as an in vivo experimental model for cardiac safety pharmacology　Matsukura, S., Nakamura, Y., Cao, X., Wada, T., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., and Sugiyama, A. 　J.Pharmacol.Sci.　133　103-109　2017　関連リンク
Original article,　Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice.　Shimizu M, Suemizu H, Mitsui M, Shibata N, Guengerich FP, Yamazaki H.　Xenobiotica　47　844-848　2017　関連リンク
Original article, 　Cloning and expression of a novel catechol-O-methyltransferase in common marmosets.　Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.　 J.Vet.Med.Sci.　79　267-272　2017　関連リンク
Perspective, 　Differences in toxicological and pharmacological responses mediated by polymorphic cytochromes P450 and related drug-metabolizing enzymes　Yamazaki, H.　Chem. Res. Toxicol.　30　53-60　2017　関連リンク
Original article, 　Sex- and age-dependent gene expression in human liver: an implication for drug-metabolizing enzymes.　Uno, Y., Takata, R., Kito, G., Yamazaki, H., Nakagawa, K., Nakamura, Y., Kamataki, T., and Katagiri, T. 　Drug Metab. Pharmacokinet.　32　100-107　2017　関連リンク
Original article, 　CYP2C76 deficiency is embryonic lethal in cynomolgus macaques: the potential role of CYP2C76 in early embryogenesis　Koyama, S., Fukuda, K., Watanabe, S., Matsushita, A., Tsuchiya, H., Fujinami, N., Hohara, S., Murayama, N., Nagano, M., Yamazaki, H., Fukuzaki, K., Uno, Y., and Hosoi, Y.　Drug Metab. Pharmacokinet.　32　112-115　2017　関連リンク
Original article, 　Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling　Kamimura, H., Ito, S., Chijiwa, H., Okuzono, T., Ishiguro, T., Yamamoto, Y., Nishinoaki, S., Mitsui, M., Kalgutkar, A. S., Ninomiya, S., Yamazaki, H., and Suemizu, H.　Xenobiotica　47　382-393　2017　関連リンク
Original article, 　Stable and episodic/bolus patterns of methylmercury exposure on mercury accumulation and histopathologic alterations in the nervous system　Sakamoto, M., Kakita, A., Domingo, J. L., Yamazaki, H., Oliveira, R. B., Sarrazin, S., Eto, K., and Murata, K.　Environ.Res.　152　446-453　2017　関連リンク
Original article, 　Marmoset cytochrome P450 4A11, a novel arachidonic acid and lauric acid omega-hydroxylase expressed in liver and kidney tissues　Uehara, S., Uno, Y., Ishii, S., Inoue, T., Sasaki, E., and Yamazaki, H.　Xenobiotica　47　553-561　2017　
Original article, 　Cytochrome P450 2A6 phenotyping using dietary caffeine salivary metabolite ratios and genotyping using blood on storage cards in non-smoking Japanese volunteers　Murayama, N., Shimizu, M., Kobayashi, K., Kishimoto, I., and Yamazaki, H. 　Drug Metab.Lett., 　10　240-243　2016　関連リンク
Review,　Upholding science in health, safety and environmental risk assessments and regulations　Aschner, M., Autrup, H. N., Berry, S. C., Boobis, A. R., Cohen, S. M., Creppy, E. E., Dekant, W., Doull, J., alli, C. L., Goodman, J. I., Gori, G. B., Greim, H. A., Joudrier, P., Kaminski, N. E., Klaassen, C. D., Klaunig, J. E., Lotti, M., Marquardt, H. W. J., Pelkonen, O., Sipes, I. G., Wallace, K., and Yamazaki, H　Toxicology　371　12-16　2016　
Review,　Whither the impending european regulation of presumed endocrine disruptors?　Autrup, H. N., Berry, S. C. L., Cohen, S. M., Creppy, E. E., de Camargo, J. L., Dekant, W., Dietrich, D., Galli, C. L., Goodman, J. I., Gori, G. B., Greim, H. A., Klaunig, J. E., Lotti, M., Marquardt, H. W., Wallace, K. B., and Yamazaki, H. 　Regul. Toxicol. Pharmacol.　82　A1-A2　2016　関連リンク
Original article, 　Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets　Uehara, S., Kawano, M., Murayama, N., Uno, Y., Utoh, M., Inoue, T., Sasaki, E., and Yamazaki, H. 　 Biochem. Pharmacol　120　56-62　2016　関連リンク
Original article, 　Roles of human CYP2A6 and monkey CYP2A24 and 2A26 cytochrome P450 enzymes in the oxidation of 2,5,2',5'-tetrachlorobiphenyl　Shimada, T., Kakimoto, K., Takenaka, S., Koga, N., Uehara, S., Murayama, N., Yamazaki, H., Kim, D., Guengerich, F. P., and Komori, M.　Drug Metab. Dispos　44　1899-1909　2016　
Original article　Physiologically based pharmacokinetic-pharmacodynamic modeling to predict concentrations and actions of sodium-dependent glucose transporter 2 inhibitor canagliflozin in human intestines and renal tubules　Mori, K., Saito, R., Nakamaru, Y., Shimizu, M., and Yamazaki, H.　 Biopharm. Drug Dispos., 　37　491–506　2016　関連リンク
Original article, 　Pre-incubation with cyclosporine A potentiates its inhibitory effects on pitavastatin uptake mediated by recombinantly expressed cynomolgus monkey hepatic organic anion transporting polypeptide　Takahashi, T., Ohtsuki, Y., Uno, Y., Utoh, M., Yamazaki, H., and Kume, T. 　Biopharm. Drug Dispos.　37　479-490　2016　関連リンク
Original article, 　Assessment of protein binding of 5-hydroxythalidomide bioactivated in humanized mice with human P450 3A-chromosome or hepatocytes by two-dimensional electrophoresis/accelerator mass spectrometry　Yamazaki, H., Suemizu, H., Kazuki, Y., Oofusa, K., Kuribayashi, S., Shimizu, M., Ninomiya, S., Horie, T., Shibata, N., and Guengerich, F. P　Chem. Res. Toxicol.　29　1279-1281　2016　関連リンク
Original article, 　Identification of putative substrates for cynomolgus monkey cytochrome P450 2C8 by substrate depletion assays with 22 human P450 substrates and inhibitors. 　Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H　Biopharm. Drug Dispos.　37　310-313　2016　関連リンク
Review, 　Combining Chimeric mice with humanized liver, mass spectrometry, and physiologically-based pharmacokinetic modeling in toxicology. 　Yamazaki, H., Suemizu, H., Mitsui, M., Shimizu, M., and Guengerich, F. P. 　Chem. Res. Toxicol.　29　1903-1911　2016　関連リンク
Review, 　Utility of non-human primates in drug development: comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes　Uno, Y., Uehara, S., and Yamazaki, H. 　Biochem. Pharmacol.　121　1-7　2016　関連リンク
Original article, 　Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes　Higuchi, Y., Kawai, K., Kanai, T., Yamazaki, H., Chesne, C., Guguen-Guillouzo, C., and Suemizu, H. 　Hepatol.Res.　46　1045-1057　2016　関連リンク
Original article, 　Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine　Uehara, S., Uno, Y., Inoue, T., Okamoto, E., Sasaki, E., and Yamazaki, H. 　Xenobiotica　46　977-985　2016　関連リンク
Original article, 　 Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling　Utoh, M., Suemizu, H., Mitsui, M., Kawao, M., Toda, A., Uehara, S., Uno, Y., Shimizu, M., Sasaki, E., and Yamazaki, H.　Xenobiotica　46　1049-1055　2016　関連リンク
Original article, 　Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing　Sakai, C., Iwano, S., Shimizu, M., Onodera, J., Uchida, M., Sakurada, E., Yamazaki, Y., Asaoka, Y., Imura, N., Uno, Y., Murayama, N., Hayashi, R., Yamazaki, H., and Miyamoto, Y.　Biopharm. Drug Dispos.　37　220-232　2016　関連リンク
Original article, 　Individual differences in metabolic clearance of S-warfarin efficiently mediated by polymorphic marmoset cytochrome P450 2C19 in livers. 　Uehara, S., Uno, Y., Inoue, T., Kawano, M., Shimizu, M., Toda, A., Utoh, M., Sasaki, E., and Yamazaki, H. 　Drug Metab. Dispos.　44　911-915　2016　関連リンク
Original article, 　Structure-function studies of naphthalene, phenanthrene, biphenyl, and their alkynyl derivatives in interaction with and oxidation by cytochromes P450 2A13 and 2A6　Shimada, T., Takenaka, S., Kakimoto, K., Murayama, N., Lim, Y.-R., Kim, D., Foroozesh, M., Yamazaki, H., Guengerich, F. P., and Komori, M. 　Chem. Res. Toxicol.　29　1029-1040　2016　関連リンク
Original article, 　A case of delayed emergence following propofol anesthesia: genetic analysis　Yonekura, H., Murayama, N., Yamazaki, H., and Sobeu, K.　Anesth.Analg.Case Rep.　7　243-246　2016　関連リンク
Original article, 　Systematic approach to optimize a pretreatment method for ultrasensitive LC/MS/MS analysis of multiple target compounds in biological samples　Togashi, K., Mutaguchi, K., Kumuro, S., Kataoka, M., Yamazaki, H., and Yamashita, S. 　J.Sep.Sci.　39　3212-3220　2016　関連リンク
Original article,　In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9　Iwasaki, K., Kitsugi, Y., Ikeda, K., Yoshikawa, T., Hosaka, S., Uehara, S., Uno, Y., Utoh, M., and Yamazaki, H.　Biopharm. Drug Dispos.　37　379-383　2016　関連リンク
原著論文　Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells　Sugiyama, I., Murayama, N., Kuroki, A., Kota, J., Iwano, S., Yamazaki, H., and Hirota, T　Xenobiotica　46　765-774　2016　関連リンク
原著論文　Human plasma concentrations of five cytochrome P450 probes extrapolated from pharmacokinetics in dogs and minipigs using physiologically based pharmacokinetic modeling　Shida, S. and Yamazaki, H　Xenobiotica　46　759-764　2016　関連リンク
原著論文　Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing.　Sakai, C., Iwano, S., Shimizu, M., Onodera, J., Uchida, M., Sakurada, E., Yamazaki, Y., Asaoka, Y., Imura, N., Uno, Y., Murayama, N., Hayashi, R., Yamazaki, H., and Miyamoto, Y. 　Biopharm. Drug Dispos.　37　220-232　2016　関連リンク
原著論文　Genomic landscape of esophageal squamous cell carcinoma in a Japanese population. 　Sawada, G., Niida, A, Uchi, R., Hirata, H., Shimamura, T., Suzuki, Y., Shiraishi, Y., Chiba, K., Imoto, S., Takahashi, Y, Iwaya, T., Hayashi, T, Takai, H., Kawasaki, Y., Matsukawa, T., Eguchi, H, Sugimachi, K., Tanaka, F, Suzuki, H., Yamamoto, K., Ishii, H., Shimizu, M., Yamazaki, H., Yamazaki, M., Tachimori, Y., Kajiyama, Y., Natsugoe, S., Fujita, H., Mafune, K, Tanaka, Y, Kelsell, D. P., Scott, C. A., Tsuji, S., Yachida, S., Shibata, T., Sugano, S., Doki, Y., Akiyama, T., Aburatani, H., Ogawa, S., Miyano, S., Mori, M., and Mimori, K. 　Gastroenterology　150　1171-1182　2016　関連リンク
原著論文　A new marmoset P450 4F12 enzyme expressed in small intestines and livers efficiently metabolizes an anti-histaminic drug ebastine. 　Uehara, S., Uno, Y., Yuki, Y., Inoue, T., Sasaki, E., and Yamazaki, H.　Drug Metab. Dispos.　44　833-841　2016　関連リンク
原著論文　Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model. 　Kazuki, Y., Akita, M., Kobayashi, K., Osaki, M., Satoh, D., Abe, S., Takehara, S., Kazuki, K., Yamazaki, H., Kamataki, T., and Oshimura, M. 　Sci.Rep.　6　21419　2016　関連リンク
原著論文　Individual differences in in vitro and in vivo metabolic clearances of antipsychotic risperidone from Japanese subjects genotyped for cytochrome P450 2D6 and 3A5. Hum.　Okubo, M., Morita, S., Murayama, N., Akimoto, Y., Goto, A., and Yamazaki, H. 　Hum.Psychopharmacol.Clin.Exp.　31　93-102　2016　関連リンク
原著論文　Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P450 2D6 and flavin-containing monooxygenase 3. Hum.　Okubo, M., Narita, M., Murayama, N., Akimoto, Y., Goto, A., and Yamazaki, H. 　Hum.Psychopharmacol.Clin.Exp.　31　83-92　2016　関連リンク
原著論文　Molecular cloning, tissue distribution, and functional characterization of marmoset cytochrome P450 1A1, 1A2, and 1B1.　Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H. 　Drug Metab. Dispos.　44　8-15　2016　関連リンク
原著論文　Caffeine 7-N-demethylation and C-8-oxidation mediated by liver microsomal cytochrome P450 enzymes in common marmosets. 　Uehara, S., Uno, Y., Inoue, T., Suzuki, T., Utoh, M., Sasaki, E., and Yamazaki, H.　Xenobiotica　46　573-578　2016　関連リンク
原著論文　In vitro inhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight into in vitro and in vivo discrepancy of metabolite formation in humans. 　Sekiguchi, K., Kanazu, T., Murayama, N., Yamazaki, H., and Yamaguchi, T.　Xenobiotica　46　495-502　2016　関連リンク
原著論文　Development of a genotyping tool for a functionally relevant CYP2C19 allele (Phe100Asn, Ala103Val, Ile112Leu) in cynomolgus macaques.　Uno, Y., Yamazaki, H.　J.Vet.Med.Sci.　78　147-148　2016　
原著論文　Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol, and midazolam, in common marmosets (Callithrix jacchus). 　Uehara, S., Inoue, T., Utoh, M., Toda, A., Shimizu, M., Uno, Y., Sasaki, E., and Yamazaki, H. 　Xenobiotica　46　163-168　2016　関連リンク
原著論文　Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene, and 1-acetylpyrene by human cytochrome P450 2A13. 　Shimada, T., Takenaka, S., Murayama, N., Kramlinger, V. M., Kim, J.-H., Kim, D., Foroozesh, M. K., Yamazaki, H., Guengerich, F. P., and Komori, M.　Xenobiotica　46　 211-224　2016　関連リンク
Original article,　 Strong induction of cytochrome P450 1A/3A, but not P450 2B, in cultured hepatocytes from common marmosets and cynomolgus monkeys by typical human P450 inducing agents　Uehara,S., Uno,Y., Suzuki,T., Inoue,S., Utoh,M., Sasaki,E., and Yamazaki,H.　Drug Metab.Lett.　10　244-253　2016.　関連リンク
総説　Meet our editorial board member　Yamazaki, H.　Curr.Drug Metab.　16　333　2015　
総説　19th International Conference on Cytochrome P450 – 第19回シトクロムP450国際会議 – 会議報告　山崎浩史、清水万紀子　薬剤学　75　380　2015　
総説　Regioselective hydroxylation of steroid hormones by human cytochromes P450.　 Niwa, T., Murayama, N., Imagawa, Y., and Yamazaki, H.　Drug Metab. Rev.　47　89-110　2015　
原著論文　Analysis of six novel flavin-containing monooxygenase 3 (FMO3) gene variants found in a Japanese population suffering from trimethylaminuria. 　Shimizu, M., Origuchi, Y., Ikuma, M., Mitsuhashi, N., and Yamazaki, H.　Mol.Genet.Metab.Report　5　89-93　2015　
原著論文　Simulation of human plasma concentrations of thalidomide and primary 5-hydroxylated metabolites explored with pharmacokinetic data in humanized TK-NOG mice. 　Nishiyama, S., Suemizu, H., Shibata, N., Guengerich, F. P., and Yamazaki, H. 　Chem. Res.Toxicol.　28　2088-2090　2015　関連リンク
原著論文　Dataset for genotyping validation of cytochrome P450 2A6 whole-gene deletion (CYP2A6*4) by real-time polymerase chain reaction platforms.　Shimizu, M., Koyama, , T., Kishimoto, I., and Yamazaki, H.　Data in Brief　5　642-645　2015　関連リンク
原著論文　Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances.　Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H.　Biopharm. Drug Dispos.　36　636-643　2015　
原著論文　Point mutation of cytochrome P450 2A6 (a polymorphic allele CYP2A6.25) confers new substrate specificity towards flavonoids. 　Uno, T., Ogura, C., Izumi, C., Nakamura, M., Yanase, T., Yamazaki, H., Ashida, H., Kanamar, K., Yamagata, H., and Imaishi, H. 　Biopharm. Drug Dispos　36　552-563　2015　
原著論文　Novel marmoset cytochrome P450 2C19 in livers efficiently metabolizes human P450 2C9 and 2C19 substrates, S-warfarin, tolbutamide, flurbiprofen, and omeprazole.　Uehara, S., Uno, Y., Inoue, S., Kawano, M., Shimizu, M., Toda, A., Utoh, M., Sasaki, E., and Yamazaki, H. 　Drug Metab. Dispos.　43　1408-1416　2015　関連リンク
原著論文　動物データに基づくヒト放射線内部被曝線量の評価－薬物動態学的方法論の応用－　杉本倫教，岩瀬由未子，弓田長彦，千葉康司，山崎浩史，池田敏彦. 　Radioisotopes　64　673-679　2015　
原著論文　Human plasma concentrations of tolbutamide and acetaminophen extrapolated from in vivo animal pharmacokinetics using in vitro human hepatic clearances and simple physiologically based pharmacokinetic modeling for radio-labeled microdose clinical studies. 　Yamazaki, H., Kunikane, E., Nishiyama, S., Murayama, N., Shimizu, M., Sugiyama, Y., Chiba, K., and Ikeda, T. 　Radioisotopes　64　509-519　2015　
原著論文　Comprehensive evaluation for substrate selectivity of cynomolgus monkey cytochrome P450 2C9, a new efavirenz oxidase. 　Hosaka, S., Murayama, N., Satsukawa, M., Uehara, S., Shimizu, M., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. 　Drug Metab. Dispos.　43　1119-1122　2015　
原著論文　Substrate selectivities and catalytic activities of marmoset liver cytochrome P450 2A6 differed from those of human P450 2A6.　Uehara, S., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.　Drug Metab. Dispos.　43　 969-976　2015　関連リンク
原著論文　Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling.　Miyaguchi, T., Suemizu, H., Shimizu, M., Shida, S., Nishiyama, S., Takano, R., Murayama, N., and Yamazaki, H.　Regul.Toxicol.Pharmacol.　72　 71-76　2015　
原著論文　Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo. 　Utoh, M., Yoshikawa, T., Hayashi, Y., Shimizu, M., Iwasaki, K., Uno, Y., and Yamazaki, H.　Biochem. Pharmacol.　95　110-114　2015　
原著論文　Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling.　Shida, S., Utoh, M., Murayama, N., Shimizu, M., Uno, Y., and Yamazaki, H.　Xenobiotica　45　881-886　2015　
原著論文　Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus). 　Uehara, S., Uno, Y., Inoue, T., Murayama, N., Shimizu, M., Sasaki, E., and Yamazaki, H. 　Drug Metab. Dispos. 　43　735-742　2015　関連リンク
原著論文　Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling.　Adachi, K., Suemizu, H., Murayama, N., Shimizu, M., and Yamazaki, H.　Environ. Toxicol. Pharmacol.　39　1067-1073　2015　
原著論文　Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol, and dextromethorphan.　Uehara, S., Uno, Y., Hagihira, Y., Murayama, N., Shimizu, M., Inoue, T., Sasaki, E., and Yamazaki, H. 　Xenobiotica　45　766-772　2015　関連リンク
原著論文　CYP2D44 polymorphisms in cynomolgus and rhesus macaques.　Uno, Y., Uehara, S., Kohara, S., Osada, N., Murayama, N., and Yamazaki,H.　Mol.Biol.Rep.　42　1149–1155　2015　
原著論文　Oxidation of acenaphthene and acenaphthylene by human cytochrome P450 enzymes.　Shimada, T., Takenaka, S., Murayama, N., Yamazaki, H., Kim, J. H., Kim, D., Yoshimoto, F. K., Guengerich, F. P., and Komori, M.　Chem. Res.Toxicol.　28　 268-278　2015　関連リンク
原著論文　Human HepaRG cells can be cultured in hanging-drop plates for cytochrome P450 induction and function assays.　Murayama, N., Usui, T., Slawny, N., Chesne, C., and Yamazaki, H.　Drug Metab.Lett.　9　3-7　2015　関連リンク
原著論文　Human pharmacokinetic profiling of the dipeptidyl peptidase-IV inhibitor teneligliptin using physiologically based pharmacokinetic modeling. 　Nakamaru, Y., Emoto, C., Shimizu, M., and Yamazaki, H.　Biopharm. Drug Dispos.　36　148-162　2015　
原著論文　Oral L-carnitine supplementation increases trimethylamine-N-oxide, but reduces markers of vascular injury in hemodialysis patients. 　Fukami, K., Yamagishi, S., Sakai, K., Kaida, Y., Yokoro, M., Ueda, S., Wada, Y., Takeuchi, M, Shimizu, M., Yamazaki, H., and Okuda, S.　J.Cardiovasc.Pharmacol.　65　 289-295　2015　
原著論文　A. Intravenous administration of apomorphine does not induce long QT syndrome: experimental evidence from in vivo canine models. 　Watanabe, Y., Nakamura, Y., Cao, X., Ohara, H., Yamazaki, Y., Murayama, N., Sugiyama, Y., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., and Sugiyama　Basic Clin.Pharmacol.Toxicol.　116　468-475　2015　
原著論文　A. Azithromycin can prolong QT interval and suppress ventricular contraction, but will not induce Torsade de Pointes. 　Ohara, H., Nakamura, Y., Watanabe, Y., Cao, X., Yamazaki, Y., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., Yamazaki, J., Ikeda, T., and Sugiyama　Cardiovasc.Toxicol.　15　232-240　2015　
原著論文　Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole, and metoprolol, in cynomolgus monkeys using in vitro-in vivo correlation.　Koyanagi, T., Nakanishi, Y., Murayama, N., Yamaura, Y., Ikeda, K., Yano, K., Uehara, S., Utoh, M., Kim, S., Uno, Y., and Yamazaki, H.　Xenobiotica　45　312-321　2015　
原著論文　Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9. 　Uno, Y., Matsushita, A., Murayama, N., and Yamazaki, H.　Drug Metab.Pharmacokinet.　30　130-132　2015　
原著論文　Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans.　Taniguchi-Takizawa, T., Shimizu, M., Kume, T., and Yamazaki, H. 　Drug Metab.Pharmacokinet.　30　64-69　2015　
原著論文　Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers.　Shimizu, M., Shiraishi, A, Sato, A., Nagashima, S., and Yamazaki, H.　Drug Metab.Pharmacokinet.　30　 70-74　2015　
原著論文　Genotyping of wild-type cytochrome P450 2A6 and whole-gene deletion using human blood samples and a multiplex real-time polymerase chain reaction method with dual-labeled probes.　Shimizu, M., Sawaya, R., Kishimoto, I., and Yamazaki, H.　Clinica Chimica Acta.　441　71-74　2015　
原著論文　Immunochemical quantification of cynomolgus CYP2J2, CYP4A, and CYP4F enzymes in liver and small intestine.　Uehara, S., Murayama, N., Nakanshi, Y., Nakamura, C., Hashizume, T., Zelden, D. C., Yamazaki, H., and Uno, Y.　 Xenobiotica　45　124-130　2015　
原著論文　Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients.　Okubo, M., Murayama, N., Miura, J., Chiba, Y., and Yamazaki, H.　Biochem. Pharmacol.　93　104-109　2015　
原著論文　Fluvoxamine by itself has potential to directly induce long QT syndrome at supratherapeutic concentrations.　Yamazaki-Hashimoto, Y., Nakamura, Y., Ohara, H., Cao, X., Kitahara, K., Izumi-Nakaseko, H., Ando, K., Yamazaki, H., Ikeda, T., Yamazaki, J., and Sugiyama, A.　J. Toxicol. Sci.　40　33-42　2015　
原著論文　Evaluation of 89 compounds for identification of substrates for cynomolgus monkey cytochrome P450 2C76, a new bupropion/nifedipine oxidase.　Hosaka, S., Murayama, N., Satsukawa, M., Shimizu, M., Uehara, S., Fujino, H., Iwasaki, K., Iwano, S., Uno, Y., and Yamazaki, H. 　Drug Metab. Dispos.　43　27-33　2015　関連リンク
原著論文　Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver.　Yamazaki, H., Kuribayashi, S., Inoue, T., Honda, T., Tateno, C., Oofusa, K., Ninomiya, S., Ikeda, T., Izumi, T., and Horie, T.　Toxicol.Res.　4　106-111　2015　
総説　Drug interactions between nine antifungal agents and drugs metabolized by human cytochromes P450.　Niwa, T., Inagawa, Y., and Yamazaki, H.　Curr.Drug Metab.　15　651-678　2014　
総説　平成26年度日本薬物動態学会学会賞を受賞して　山崎浩史　Drug Metab.Pharmacokinet.　29(6)　15-17　2014　
総説　私立薬大での薬物動態学研究室の立ち上げ(2)　山崎浩史　Drug Metab.Pharmacokinet.　29(6)　39-42　2014　
総説　私立薬大での薬物動態学研究室の立ち上げ(1)　山崎浩史　Drug Metab.Pharmacokinet.　29(5)　21-24　2014　
総説　Drug-induced liver toxicity studies: research into human metabolites clarifies their role in drug development. 　Yamazaki, H. 　Drug Metab.Pharmacokinet.　29　111　2014　
原著論文　Species differences in the pharmacokinetic parameters of cytochrome P450 probe substrates between experimental animals, such as mice, rats, dogs, monkeys, and microminipigs, and humans.　Sakai, C., Iwano, S., Yamazaki, Y., Ando, Y., Nakane, F., Kouno, M., Yamazaki, H., and Miyamoto, Y. 　J. Drug Metab.Toxicol.　5　173　2014　
原著論文　Identification and analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1, and CYP51A1 in cynomolgus macaques. 　Uno, Y., Hosaka, S., and Yamazaki, H.　J.Vet.Med.Sci.　76　1647-1650　2014　
原著論文　Comparison of catalytic properties of cytochromes P450 3A4 and 3A5 by molecular docking simulation.　Niwa T, Yasumura M, Murayama N and Yamazaki H.　Drug Metab.Lett.　8　43-50　2014　
原著論文　Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes. 　Suemizu, H., Sota, S., Kuronuma, M., Shimizu, M., and Yamazaki, H.　Regul.Toxicol.Pharmacol.　70　468-473　2014　
原著論文　CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques. 　Uno, Y., Matsushita, A., Shukuya, M., Matsumoto, Y., Murayama, N., and Yamazaki, H. 　Biochem. Pharmacol.　91　 242-248　2014　
原著論文　Polymorphisms of CYP2D17 in cynomolgus and rhesus macaques: an evidence of the genetic basis for the variability of CYP2D-dependent drug metabolism.　Uno, Y., Uehara, S., Kohara, S., Murayama, N., and Yamazaki, H.　Drug Metab. Dispos.　42　1407-1410　2014　関連リンク
原著論文　Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling. 　Yamashita, M., Suemizu, H., Murayama, N., Nishiyama, S., Shimizu, M., and Yamazaki, H.　Regul.Toxicol.Pharmacol. 　70　214-221　2014　
原著論文　Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencing.　Shimizu, M., Iwano, S., Uno, Y., Uehara, S., Inoue, T., Murayama, N., Onodera, J., Sasaki, E., and Yamazaki, H.　PLoS One　9　e100936　2014　
原著論文　Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs.　Yamazaki, M., Shimizu, M., Uno, Y., and Yamazaki, H.　Biochem. Pharmacol.　90　159-165　2014　
原著論文　Trimethylamine generation in patients receiving hemodialysis treated with L-carnitine. 　Ozasa, H., Shimizu, M., Koizumi, A., Wakabayashi, A., and Yamazaki, H.　Clin.Kidney J.　7　329　2014　
原著論文　A survey of adverse effects and risk factors for topical application of diclofenac (in Japanese)　Ohyama, K., Shimizu, M., and Yamazaki, H.　Jpn. J. Pharm. Health Care Sci.　40　310-316　2014　
原著論文　K. Effect of ketoconazole on the pharmacokinetics of the dipeptidyl peptidase-4 Inhibitor teneligliptin: an open-label study in healthy white subjects in Germany.　Nakamaru, Y., Hayashi, Y., Sekine, M., Kinoshita, S., Thompson, J., Kawaguchi, A., Davies, M., Jurgen, Heuer H., Yamazaki, H., and Akimoto　Clin.Ther.　36　760-769　2014　
原著論文　Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig. Biopharm.　Higashi, E., Ando, A., Iwano, S., Murayama, N., Yamazaki, H., and Miyamoto, S. 　Drug Dispos.　35　313-320　2014　
原著論文　Koyanagi, T., Yamaura, K., Yano, K., Kim, S., and Yamazaki, H. 　Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs.　Xenobiotica　44　893-901　2014　
原著論文　Yajima, K., Uno, Y., Murayama, N., Uehara, S., Shimizu, M., Nakamura, C., Iwasaki, K., Utoh, M., and Yamazaki, H.　Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes P450. 　Drug Metab. Dispos　42　867-871　2014　
原著論文　Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys.　Uehara, S., Murayama, N., Nakanishi, Y., Nakamura, C., Hashizume, T., Zelden, D. C., Yamazaki, H., and Uno, Y.　Xenobiotica　44　769-774　2014　
原著論文　Voriconazole metabolism, toxicity and the effect of cytochrome P450 2C19 genotype. 　Zonios, D., Yamazaki, H., Murayama, N., Natrarajan, V., Palmore, T., Childs, R., Skinner, J., and Bennett, J.　J.Infect.Dis.　209　1941-1948　2014　関連リンク
原著論文　Relationships between flavin-containing monooxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population.　Shimizu, M., Allerston, C. K., Shephard, E. A., Yamazaki, H.and Phillips, I. R.　Brit.J. Clin. Pharmacol.　77　839-851　2014　
原著論文　Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of pregnane X receptor.　Murayama, N., van Beuningen, R., Suemizu, H., Guguen-Guillouzo, C., Shibata, N., Yajima, K., Utoh, M., Shimizu, M., Chesne, C., Nakamura, M., Guengerich, F. P., Houtman, R., and Yamazaki, H.　Chem. Res.Toxicol.　27　304-308　2014　関連リンク
原著論文　Metabolism and disposition of the dipeptidyl peptidase IV inhibitor teneligliptin in humans.　264. Nakamaru, Y., Hayashi, Y., Ikegawa, R., Kinoshita, S., Madera, B. P., Gunput, D., Kawaguchi, A., Davies, M., Mair, S., Yamazaki, H., Kume, T., and Suzuki, M.　Xenobiotica　44　242-253　2014　
原著論文　Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation. 　Ohyama, K., Murayama, N., Shimizu, M., and Yamazaki, H.　Xenobiotica　44　10-16　2014　
原著論文　Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analog of thalidomide.　Chowdhury G, Shibata N, Yamazaki H., and Guengerich FP.　Chem. Res.Toxicol.　27　147-156　2014　
原著論文　The human hepatic cell line HepaRG cells, possible cell source for steady generation of humanized liver TK-NOG mice.　Higuchi, Y., Kawai, K., Yamazaki, H., Nakamura, M., Bree, F., Guillouzo, C., and Suemizu, H. 　Xenobiotica　44　146-153　2014　
Original article, 　 Interleukin-1β and tumor necrosis factor-α affect cytochrome P450 expression in cynomolgus macaque hepatocytes　Uno Y, Murayama N, Yamazaki H..　Drug Metab and Pharmacokinet,　35　341-343　2000　
Original article, 　Systematic characterization of glutathione S-transferases in common marmosets　Uno Y, Uehara S, Tanaka S, Murayama N, and Yamazaki H. 　Biochem Pharmacol 　174　113835　2000　関連リンク
Original article, 　Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity　Kamiya, Y., Takaku, H., Yamada, R., Akase, C., Abe, Y., Sekiguchi, Y., Murayama, N., Shimizu, M., Kitajima, M., Shono, F., Funatsu, K., and Yamazaki, H. 　Toxicol. Rep.　7　149-154　2000　
Original article, 　Cloning and tissue expression of ATP-binding cassette transporters in cynomolgus macaques　Uno, Y., and Yamazaki, H. 　Drug Metab Pharmacokinet　42　100431　 2022.　関連リンク

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招待講演　 “Metabolic profile of 14C-diisononyl phthalate using pharmacokinetic modelling and chimeric mouse with humanized-liver”,　Hiroshi Yamazaki　International Scientific Meeting of Plasticisers and Science – State of the Art　Speyer, Germany　September 2018
特別講演　 “Combining Humanized-liver Mice Model and Pharmacokinetic Modeling in Drug Metabolism and Disposition”　Hiroshi Yamazaki　2020 Shanghai PKPD Forum　 Shanghai, China (online)　November 25, 2020
特別講演　“A physiologically based pharmacokinetic model to predict chemical concentrations in livers after virtual oral doses”　Hiroshi Yamazaki　Tokyo AI-SHIPS International Symposium; the front line of development of in silico toxicity prediction system.　Tokyo, Japan.　November 2018
招待講演　“Adult and infant pharmacokinetic profiling of dihydrocodeine by Simcyp”　Hiroshi Yamazaki　11th Annual Simcyp Virtual Seminar on Applications of Population-based IVIVE and PBPK, 　Sheffield,UK (online)　November 11 and 18, 2020
招待講演　”Roles of Human Cytochrome P450 Enzymes in Drug Oxidation: Comparison of In Vitro and In Vivo System Results”,　Hiroshi Yamazaki　21st International Conference on Cytochrome P450 ~Biochemistry, Biophysics, Biotechnology~　 Brisbane, Australia　June 23－27, 2019
特別講演?シンポジウム　Representative phthalate pharmacokinetics in chimeric mice with humanized liver　Hiroshi Yamazaki　Green Plasticizer Development Forum 2016　Shanghai　2016/04/23～2016/04/25
ポスター発表　抗てんかん薬オクスカルバゼピンの代謝酵素誘導能に関する研究　黒木彩加、村山典恵、杉山育男、岩野俊介、山崎浩史、廣田孝司　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
ポスター発表　向精神病薬カルバマゼピンがもたらすヒトP4503A酵素との薬物相互作用　村山典恵、倉林優貴、日川美紀子、大久保真穂、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
ポスター発表　日本人におけるトリメチルアミン尿症の一因となる新規フラビン含有モノオキシゲナーゼ3ハプロタイプの解析　牧野美紀、清水万紀子、徳山瑛美、梶谷綾、渡邊碧、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
ポスター発表　日本人におけるトリメチルアミン尿症の原因となる新規フラビン含有モノオキシゲナーゼ3遺伝子変異の解析　徳山瑛美、清水万紀子、牧野美紀、梶谷綾、渡邊碧、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
ポスター発表　ヒト肝細胞移植マウスおよびマーモセット生理学的薬物動態モデルを活用したチトクロムP450カクテル基質のヒト血中濃度推移予測　清水万紀子、三井満里奈、河野未来、上原正太郎、宇野泰広、鵜藤雅裕、井上貴史、佐々木えりか、末水洋志、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
ポスター発表　新規マーモセットP450 2J酵素の同定および機能解析　上原正太郎、岡本絵里子、宇野泰広、井上貴史、佐々木えりか、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
口頭発表　マーモセット肝のワルファリン酸化的代謝の立体選択性　河野未来、上原正太郎、石井さくら、宇野泰広、井上貴史、鵜藤雅裕、佐々木えりか、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
ポスター発表　マーモセットあるいはカニクイザル肝細胞を用いた薬物暴露によるチトクロムP450誘導の評価　鈴木貴子、上原正太郎、村山典恵、宇野泰広、矢島加奈子、鵜藤雅裕、井上貴史、佐々木えりか、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
ポスター発表　マーモセットおよびカニクイザル小腸P450酵素によるエバスチン酸化的代謝　上原正太郎、結城友香子、宇野泰広、井上貴史、佐々木えりか、山崎浩史　日本薬学会第136年会　横浜　2016/03/26～2016/03/29
ポスター発表　An Association between Plasma and Urinary Levels of Trimethylamine-N-oxide(TMAO) and Metabolic Factors in a Population of Community-dwelling Japanese.　Ako Fukami, Hisashi Adachi, Mika Enomoto, Eita Kumagai, Sachiko Nakamura, Yume Nohara, Erika Nakao, Nagisa Morikawa, Tomoko Tsuru, Hiroshi Yamazaki, Kei Fukami, and Yoshihiro Fukumoto　第80回日本循環器学会学術集会　仙台　2016/03/18～2016/03/20
特別講演?シンポジウム　ヒト放射線内部被曝線量評価の実際およびAPDDの提案　池田敏彦、村山典恵、山崎浩史　北里-APDD合同シンポジウム　－ヒトRI試験の実施指針－　東京　2016/03/14
特別講演?シンポジウム　薬物代謝酵素の多型と代謝物に民族差を生ずる可能性-日本人におけるヒトRI試験の重要性- 　山崎浩史　北里-APDD合同シンポジウム　－ヒトRI試験の実施指針－　東京　2016/03/14
ポスター発表　In Vivo Model for Predicting Organophosphate Toxicity using Humanized-Liver TK-NOG Mouse　Hiroshi Suemizu, Miyuki Kuronuma, Kenji Kawai, Norie Murayama, Masato Nakamura and Hiroshi Yamazaki　The Society of Toxicology 55th Annual Meeting　New Orleans, USA　2016/03/13～2016/03/17
口頭発表　ニコチン代謝酵素チトクロム P450 2A6 野生型および全欠損型遺伝子判定法の比較　岸本いずみ、清水万紀子、梶谷綾、山崎浩史　第70回聖マリアンナ医科大学医学会学術集会　川崎　2016/03/12
特別講演?シンポジウム　Metabolic Activation of Xenobiotics by Polymorphic Drug-metabolizing Enzymes　Hiroshi Yamazaki　The 13th Asia Pacific Federation of Pharmacologist Meeting (APFP)　Thailand　2016/02/01～2016/02/03
特別講演?シンポジウム　ヒト薬物動態予測を目指したサル、マーモセットとヒト肝細胞移植マウスの活用研究　山崎浩史　第38 回薬物動態談話会年会　浜松　2015/11/30～2015/12/01
ポスター発表　腎機能障害時における薬物間相互作用の予測：DPP-4阻害薬テネリアを例として　清水秀俊、仲丸善喜、山崎浩史、久米俊行　第25回日本医療薬学会年会　横浜　2015/11/21～2015/11/23
特別講演?シンポジウム　Comparison of drug oxidations in humans, primates, and rodents　Hiroshi Yamazaki　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
特別講演?シンポジウム　Flavin-containing monooxygenase 3: Individual differences and drug interactions　Makiko Shimizu and Hiroshi Yamazaki　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
ポスター発表　Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes　Yuichiro Higuchi, Kenji Kawai, Tatsuro Kanaki, Hiroshi Yamazaki, Chesne Cristophe, Guguen-Guillouzo Christiane, Hiroshi Suemizu　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
ポスター発表　Pharmacokinetics of efavirenz after oral and intravenous administration of efavirenz to genotypedcynomolgus monkeys　Yusuke Kitsugi, Kanami Ikeda, Atsushi Matsuoka, Takaaki Tokunaga, Natsumi Tomida, Haruka Shirosawa, Takahiro Yoshikawa, Yasuhiro Uno, Kazuhide Iwasaki, Masahiro Utoh, Hiroshi Yamazaki, Shinya Hosaka　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
ポスター発表　Comparison of catalytic properties in cytochrome P450 3A4 and 3A5 for various compounds including　endogenous steroid hormones by molecular docking simulation　Toshiro Niwa, Norie Murayama, Yurie Imagawa, Hiroshi Yamazaki　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
ポスター発表　Time-dependent inhibition of OATP-mediated transport by cyclosporine A is reproduced in cynomolgus monkeys　Tsuyoshi Takahashi, Tatsuyuki Ohtsuka, Yasuhiro Uno, Hiroshi Yamazaki, Toshiyuki Kume　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
ポスター発表　Induction of drug metabolizing enzymes by thalidomide dependent on pregnane X receptor (PXR) in human livers as evident using PXR-knockout HepaRG cells　Norie Murayama, Kanako Yajima, and Hiroshi Yamazaki　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
ポスター発表　Analysis of cytochrome P450 regulators in cynomolgus macaque　Yasuhiro Uno and Hiroshi Yamazaki　30th JSSX Annual Meeting　東京　2015/11/12～2015/11/14
ポスター発表　Cytochrome P450-dependent warfarin and caffeine metabolism in marmosets, monkeys, and humans　Hiroshi Yamazaki, Shotaro Uehara, Yasuhiro Uno, and Erika Sasaki　20th North American ISSX Meeting　Orlando, USA　2015/10/18～2015/10/22
ポスター発表　マーモセット肝のワルファリン代謝の解析　河野未来、上原正太郎、宇野泰広、鵜藤雅裕、佐々木えりか、山崎浩史　第59回日本薬学会関東支部大会　東京　2015/09/12
ポスター発表　マーモセット肝のカフェイン代謝経路の解析　鈴木貴子、上原正太郎、宇野泰広、鵜藤雅裕、佐々木えりか、山崎浩史　第59回日本薬学会関東支部大会　東京　2015/09/12
特別講演?シンポジウム　Human Drug Metabolism by Cytochrome P450 Enzymes　Hiroshi Yamazaki　2nd Symposium of SPU Innovative Project for Pharmaceutical Analyses of Covalent Modification in Biomolecules　東京　2015/09/01
特別講演?シンポジウム　カニクイザルにおけるチトクロムP450とグルクロン酸転移酵素の解析　宇野泰広、山崎浩史　第42回日本毒性学会学術集会　金沢　2015/06/29～2015/07/01
特別講演?シンポジウム　実験動物およびヒトの薬物酸化酵素活性の比較　山崎浩史、宇野泰広　第42回日本毒性学会学術集会　金沢　2015/06/29～2015/07/01
口頭発表　日本人のトリメチルアミン尿症に関する大規模調査　千葉布季子、清水万紀子、牧野美紀、三觜菜々子、友田沙也加、山崎浩史　第69回聖マリアンナ医科大学医学会学術集会　川崎　2015/06/27
口頭発表　血液透析患者におけるFMD値とtrimethylamine-N-oxide、心血管病変との検討　西谷光広、上出亜希子、後藤厚子、武田麻有里、寺中久代、森内則子、山森満寿美、保志場紀子、澤﨑真由美、上田律子、大門正一郎、清水万紀子、山崎浩史　第60回日本透析医学会学術集会　横浜　2015/06/26～2016/06/28
ポスター発表　当クリニックにおける魚臭症候群の一例を経験して　森内則子、西谷光広、澤﨑真由美、保志場紀子、山森満寿美、寺中久代、武田麻有里、後藤厚子、上出亜希子、上田律子、大門正一郎、清水万紀、山崎浩史　第60回日本透析医学会学術集会　横浜　2015/06/26～2016/06/28
ポスター発表　Comprehensive evaluation for substrate selectivity of cynomolgus monkey cytochrome P450 2C enzymes　Shinya Hosaka, Norie Murayama, Masahiro Satsukawa, Shotaro Uehara, Makiko Shimizu, Kazuhide Iwasaki, Shunsuke Iwano, Yasuhiro Uno, Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
ポスター発表　Human cytochromes P450-mediated regioselective hydroxylation of steroid hormones　Toshiro Niwa, Norie Murayama, Yurie Imagawa, and Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
ポスター発表　Identification and analysis of CYP2B6 variants in cynomolgus and rhesus macaques　Yasuhiro Uno, Shotaro Uehara, and Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
ポスター発表　Molecular cloning, expression and functional characterization of marmoset cytochrome P450 2A6 　Shotaro Uehara, Yasuhiro Uno, Norie Murayama, Makiko Shimizu, Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
ポスター発表　Mutations of flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria　Makiko Shimizu and Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
ポスター発表　The modulation of physiological condition for expression of P450s in differential cryopreserved HepaRG cells　Norie Murayama, Kanako Yajima, Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
ポスター発表　In Vivo R/S-Warfarin Metabolism Mediated by Polymorphic P450 2C19 in Cynomolgus Monkeys　Masahiro Utoh, Takahiro Yoshikawa, Makiko Shimizu, Kazuhide Iwasaki, Yasuhiro Uno, Hiroshi Yamazaki　19th International Conference on Cytochrome P450　東京　2015/06/12～2015/06/15
特別講演?シンポジウム　多型と麻酔薬の体内動態　山崎浩史　日本麻酔科学会第62 回学術集会　神戸　2015/05/28～2015/05/30
ポスター発表　薬物代謝型cytochrome P450及びステロイド代謝酵素によるステロイド代謝　丹羽俊朗、村山典恵、今川友里恵、山崎浩史　日本薬剤学会第30年会　長崎　2015/05/21～2015/05/23
ポスター発表　Cytochrome P450 (CYP、P450) 3A4及びCYP3A5を含むヒト代謝型P450に対する各種抗真菌薬の相互作用　今川友里恵、村山典恵、山崎浩史、丹羽俊朗　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
ポスター発表　Cytochrome P450 (CYP、P450) 3A4及びCYP3A5を含む各種ヒトP450によるステロイド代謝　丹羽俊朗、村山典恵、今川友里恵、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
ポスター発表　カニクイザル生理学的薬物動態モデルを活用したチトクロム P450 カクテル基質のヒト血中濃度推移予測　志田聡美、村山典恵、清水万紀子、鵜藤雅裕、宇野泰広、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
口頭発表　サリドマイド 1 次および 2 次酸化的代謝に関与するチトクロム P450 の種差　西山咲弥子、清水万紀子、上原正太郎、宇野泰広、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
ポスター発表　日本人トリメチルアミン尿症の大規模詳細調査　千葉布季子、清水万紀子、徳山瑛美、牧野美紀、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
口頭発表　サリドマイドによるヒトP450酵素自己誘導機構に及ぼす要因　村山典恵、矢島加奈子、柴田哲男、鵜藤雅裕、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
口頭発表　カニクイザルシトクロムP450 2C9の基質特異性に関する検討　保坂信哉、村山典恵、薩川正広、上原正太郎、清水万紀子、岩﨑一秀、岩野俊介、宇野泰広、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
口頭発表　チトクロム P450 2A6 野生型と全欠損型遺伝子の迅速判定法　清水万紀子、岸本いずみ、小山智生、澤谷怜、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
ポスター発表　抗精神病薬オランザピン投与日本人患者における血漿中薬物濃度の個人差　大久保真穂、成田桃子、村山典恵、森田翔子、中村浩也、清水万紀子、秋元洋一、後藤晶子、○山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
口頭発表　抗精神病薬リスペリドン投与日本人患者における血漿中薬物濃度の個人差　大久保真穂、村山典恵、森田翔子、森亜沙美、倉林優貴、秋元洋一、後藤晶子、山崎浩史　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
特別講演?シンポジウム　マーモセット、カニクイザルおよびヒトの薬物酸化酵素活性の比較　山崎浩史、上原正太郎、宇野泰広　第4回日本マーモセット研究会大会　犬山　2015/01/22～2015/01/23
口頭発表　日本人のトリメチルアミン尿症の一因となるフラビン含有モノオキシゲナーゼ3遺伝子変異の解析　伊熊鞠佳、清水万紀子、三觜菜々子、友田沙也加、山崎浩史　第68回聖マリアンナ医科大学医学会学術集会　川崎　2014/12/11～2014/12/12
口頭発表　レボカルニチン製剤を使用した透析患者の血中トリメチルアミン濃度　山崎浩史、清水万紀子、小篠榮　第35回日本臨床薬理学会年会　松山　2014/12/04～2014/12/06
口頭発表　日本人集団から見出されたトリメチルアミン尿症の原因となるフラビン含有酸素添加酵素3遺伝子多型　清水万紀子、折口裕美、伊熊鞠佳、三觜菜々子、友田沙也加、山崎浩史　第35回日本臨床薬理学会年会　松山　2014/12/04～2014/12/06
ポスター発表　Comparison of pharmacokinetics parameters of cytochrome P450 probe substrates in humans, mice, rats, dogs, monkeys, and microminipigs　Chizuka Sakai, Shunsuke Iwano, Yuri Yamazaki, Akihiro Ando, Hiroshi Yamazaki, Yohei Miyamoto　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
ポスター発表　Warfarin metabolism mediated by polymorphic P450 2C19 in cynomolgus monkeys　Hiroshi Yamazaki, Yasuhiro Uno, Mitsunori Shukuya, Takahiro Yoshikawa, Yasuka Matsumoto, Akinori Matsushita, Norie Murayama, Koichiro Fukuzaki, Masahiro Utoh　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
ポスター発表　Genetic polymorphisms in flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population　Makiko Shimizu, Hiroshi Yamazaki　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
ポスター発表　Roles of auto-induction of human P450 3A enzymes involved in the teratogenicity of thalidomide　Norie Murayama, Christophe Chesné, F. Peter Guengerich, Hiroshi Yamazaki　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
ポスター発表　Oxidative metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by liver and brain microsomes from common marmosets　Shotaro Uehara, Norie Murayama, Makiko Shimizu, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
ポスター発表　Effects of CYP2D6 and CYP3A5 genotypes and co-administrated drugs on the metabolic　clearance of antidepressant mirtazapine　Maho Okubo, Norie Murayama, Jun Miura, Yasuji Chiba, Hiroshi Yamazaki　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
特別講演?シンポジウム　Metabolic activation and fate of xenobiotics determined by polymorphic drug-metabolizing enzymes.　Hiroshi Yamazaki　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
特別講演?シンポジウム　Reactive metabolite formation of drugs by human P450s in chimeric mice with humanized liver.　Hiroshi Yamazaki　19th North American ISSX/ 29th JSSX Annual Meeting　San Francisco　2014/10/19～2015/10/23
ポスター発表　レボカルニチン投与時の透析患者におけるトリメチルアミンおよび N -酸化体の体内運命の検討　小泉綾乃、若林あかり、清水万紀子、小篠榮、山崎浩史　第58回日本薬学会関東支部大会　東京　2014/10/04
ポスター発表　抗うつ薬ミルタザピンの代謝消失に関わる薬物代謝酵素　森亜沙美、大久保真穂、成田桃子、森田翔子、村山典恵、三浦淳、千葉泰二、山崎浩史　第58回日本薬学会関東支部大会　東京　2014/10/04
口頭発表　サリドマイド代謝的活性化における霊長類チトクロム P450 の役割　西山咲弥子、清水万紀子、上原正太郎、宇野泰広、山崎浩史　第58回日本薬学会関東支部大会　東京　2014/10/04
ポスター発表　ヒト肝移植マウスを活用した生理学的薬物動態モデルによるフタル酸ビス２エチルヘキシルのヒト体内動態予測　安達昂一郎、宮口貴守、村山典恵、末水洋志、山崎浩史　第58回日本薬学会関東支部大会　東京　2014/10/04
ポスター発表　薬局の大規模データを用いたジクロフェナク局所皮膚適用製剤の副作用発現とリスク因子に関する検討　大山勝宏、高橋真二、福岡勝志、清水万紀子、山崎浩史　第24回日本医療薬学会年会　名古屋　2014/09/27～2014/09/28
ポスター発表　Drug interaction of antifungal agents against cytochrome P450s　Toshiro Niwa, Yurie Imagawa, Motohiro Yasumura, Norie Murayama, Hiroshi Yamazaki　12th International Symposium on Cytochrome P450 Biodiversity & Biotechnology　京都　2014/09/24～2014/09/28
口頭発表　ヒト肝細胞HepaRGにおける環境化学物質の細胞毒性と薬物代謝酵素誘導能について　曽根秀子、村山典恵、王文龍、曾洋、南齋ひろ子、曾勤、山崎浩史　フォーラム2014　衛生薬学?環境トキシコロジー　つくば　2014/09/19～2014/09/20
口頭発表　カニクイザル硫酸転移酵素の同定?解析　宇野泰広、村山典恵、山崎浩史　第157回日本獣医学会学術集会　札幌　2014/09/09～2014/09/12
口頭発表　代謝酵素遺伝子多型および併用薬が抗うつ薬ミルタザピンの代謝消失に及ぼす影響　森田翔子、大久保真穂、森亜沙美、村山典恵、三浦淳、千葉泰二、山崎浩史　第67回聖マリアンナ医科大学医学会学術集会　川崎　2014/07/10～2014/07/11
特別講演?シンポジウム　安全性評価を支える薬物動態試験のあり方　山崎浩史　第41回日本毒性学会学術集会　神戸　2014/07/02～2014/07/04
ポスター発表　カニクイザルの小腸におけるUDP-グルクロン酸転移酵素活性の性差、産地差および部位差　中西康晴、中村稚加、岩崎一秀、鵜藤雅裕、山崎浩史、宇野泰広　第41回日本毒性学会学術集会　神戸　2014/07/02～2014/07/04
特別講演?シンポジウム　レボカルニチンを使う透析患者さんの体臭を科学する－個の医療－　山崎浩史　医療薬学フォーラム2014／第22回クリニカルファーマシーシンポジウム　東京　2014/06/28～2014/06/29
ポスター発表　透析患者のレボカルニチン（LC）投与時における内服薬と注射薬の血中トリメチルアミン（TMA）及びN-酸化体（TMAO）値への影響　小篠榮、前田弘美、井戸田昭子、久保和雄、鈴木敦、鈴木利昭、小泉綾乃、若林あかり、清水万紀子、山崎浩史　第59回日本透析医学会学術集会?総会　神戸　2014/06/13～2014/06/15
ポスター発表　各種cytochrome P450に対する抗真菌薬の相互作用　丹羽俊朗、今川友里恵、山崎浩史　日本薬剤学会第29年会　さいたま　2014/05/20～2014/05/22
特別講演　“Human drug metabolism and disposition in humanized-liver mice and non-human primate models”　Hiroshi Yamazaki　2018 International Meeting on 22nd MDO and 33rd JSSX　Kanazawa, Japan　 October 1-5, 2018
招待講演　“Human plasma and urinary metabolic profiles of trimethylamine and its N-oxide extrapolated using humanized-liver mice and simple physiologically based pharmacokinetic models”,　Hiroshi Yamazaki　57th Annual Meeting of the Society of Toxicology　San Antonio, Texas, USA　 March 11–15, 2018
特別講演　 “Human drug metabolism in humanized-liver mice and non-human primate models”.　Hiroshi Yamazaki　20th International Conference on Cytochrome P450 ~Biochemistry, Biophysics, Biotechnology~　Düsseldorf, Germany　 August, 27－31, 2017

すべて表示する

競争的資金等

ORCid ID (0000-0002-1068-4261)を参照
http://www.researcherid.com/rid/A-6081-2011

一般公演

薬物代謝学、薬物動態学関連多数

社会における活動

社）医薬品開発支援機構(APDD) 理事(2008～)、総務担当理事(2010-18）、代表理事(2018-)、内閣府食品安全委員会専門委員（2006-16）、消費者庁食品衛生基準審議会専門委員 (2024-)、International Advisory Committee member (2009-) for International Conferences on Cytochrome P450; International Advisory Committee memebr (2020-) for International Meetings on Microsomes and Drug Oxidations

山崎 浩史教授 / 博士（薬学）last update : 2024.10.16

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研究業績（著書）

研究業績（論文）

研究業績（学会発表等）

競争的資金等

一般公演

社会における活動

山崎浩史教授 / 博士（薬学）last update : 2024.10.16