Profile

Name

Hiromichi Akizawa

Affiliation

Laboratory of Physical Chemistry

Subjects

　

Official title

Professor

Degree

Ph.D.

Books

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• マクマリー 生物有機化学 基礎化学編 第４版（原書第７版）　秋澤宏行（訳）　第11章　核化学　352-382　丸善出版　2015　978-4-621-08895-1
• コンパス 物理化学 改訂第2版　秋澤宏行　13章　放射線と放射能　223-238　南江堂　2014　978-4-524-40315-8
• NEW 放射化学?放射薬品学 (第2版)　秋澤宏行、村上美穂　第4章　放射線測定法（第5-8節）　66-76　廣川書店　2011　978-4-567-26151-7
• 無機化合物?錯体 －生物無機化学の基礎－ (第2版)　秋澤宏行　第2章　放射性同位体 (放射性核種)　25-35　廣川書店　2010　978-4-567-21151-2
• Technetium-99m Radiopharmaceuticals: Status and Trends.　H. Akizawa, T. Uehara, Y. Arano.　Chapter 12. Technetium-99m radiopharmaceuticals for monitoring drug resistance　255-267　Publishing Section, International Atomic Energy Agency　2009　978-92-0-103509-7
• Technetium-99m Radiopharmaceuticals: Status and Trends.　T. Uehara, H. Akizawa, Y. Arano.　Chapter 13. Technetium-99m radiopharmaceuticals for lymphoscintigraphy　269-280　Publishing Section, International Atomic Energy Agency　2009　978-92-0-103509-7

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Papers

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• [Original paper]　Ex vivo imaging and analysis of ROS generation correlated with microglial activation in rat model with acute neuroinflammation induced by intrastriatal injection of LPS.　M. Shukuri, M. Uchino, T. Sakamaki, S. Onoe, R. Hosoi, K. Todoroki, Y. Arano, T. Sakai, H. Akizawa, O. Inoue.　Biochem. Biophys. Res. Commun.　584　101-106　2021　
• [Original paper]　Influence of linker molecules in hexavalent RGD peptides on their multivalent interactions with integrin α_vβ₃.　Y. Mizuno, K. Kimura, S. Onoe, M. Shukuri, Y. Kuge, H. Akizawa.　J. Med. Chem.　64(21)　16008-16019　2021　
• [Original paper]　Aryl isocyanide derivative for one-pot synthesis of purification-free ^99mTc-labeled hexavalent targeting probe.　Y. Mizuno, T. Uehara, C. Jen, H. Akizawa, Y. Arano.　Nucl. Med. Biol.　86-87　30-36　2020　
• [Original paper]　The synthesis of a ^99mTc-labeled tetravalent targeting probe upon isonitrile coordination to ^99mTc^I for enhanced target uptake in saturable systems.　Y. Mizuno, T. Uehara, C. Jen, H. Akizawa, Y. Arano.　RSC Adv.　9　26126-26135　2019　
• [Original paper]　Coordination-mediated synthesis of purification-free bivalent ^99mTc-labeled probes for in vivo imaging of saturable system.　Y. Taira, T. Uehara, M. Tsuchiya, H. Takemori, Y. Mizuno, S. Takahashi, H. Suzuki, H. Hanaoka, H. Akizawa, Y. Arano.　Bioconjugate Chem.　29(2)　459-466　2018　
• [Original paper]　¹¹¹In-DTPA-D-Phe^-1-Asp⁰-D-Phe¹-octreotide exhibits higher tumor accumulation and lower renal radioactivity than ¹¹¹In-DTPA-D-Phe¹-octreotide.　N. Oshima, H. Akizawa, H. Kitaura, H. Kawashima, S. Zhao, Y. Zhao, K. Nishijima, Y. Kitamura, Y. Arano, Y. Kuge, K. Ohkura.　Nucl. Med. Biol.　54　18-26　2017　
• [Original paper]　Redesign of negatively charged ¹¹¹In-DTPA-octreotide derivative to reduce renal radioactivity.　N. Oshima, H. Akizawa, H. Kawashima, S. Zhao, Y. Zhao, K. Nishijima, Y. Kitamura, Y. Arano, Y. Kuge, K. Ohkura.　Nucl. Med. Biol.　48　16-25　2017　
• [Original paper]　The Thymidine Phosphorylase Imaging Agent ¹²³I-IIMU Predicts the Efficacy of Capecitabine.　N. Kobashi, H. Matsumoto, S. Zhao, S. Meike, Y. Okumura, T. Abe, H. Akizawa, K. Ohkura, K. Nishijima, N. Tamaki, Y. Kuge.　J. Nucl. Med.　57(8)　1276-1281　2016　
• [Original paper]　Relationship between biodistribution of a novel thymidine phosphorylase (TP) imaging probe and TP expression levels in normal mice.　Zhao S, Li H, Nishijima K, Zhao Y, Akizawa H, Shimizu Y, Ohkura K, Tamaki N, Kuge Y.　Ann. Nucl. Med.　29(7)　582-587　2015　
• [Original paper]　Design, synthesis and biological evaluation of negatively charged ¹¹¹In-DTPA-octreotide derivatives.　N. Oshima, H. Akizawa, S. Zhao, Y. Zhao, K. Nishijima, Y. Kitamura, Y. Arano, Y. Kuge, K. Ohkura　Bioorg. Med. Chem.　22(4)　1377-1382　2014　
• [Original paper]　Renal brush border enzyme-cleavable linkages for low renal radioactivity levels of radiolabeled antibody fragments.　H. Akizawa, M. Imajima, H. Hanaoka, T. Uehara, S. Satake, Y. Arano.　Bioconjugate Chem.　24(2)　291-299　2013　
• [Original paper]　Chemical Design of ^99mTc-Labeled Probes for Targeting Osteogenic Bone Region.　M. Yanagi, T. Uehara, Y. Uchida, S. Kiyota, M. Kinoshita, Y. Higaki, H. Akizawa, H. Hanaoka, Y. Arano.　Bioconjugate Chem.　24(7)　1248-1255　2013　
• [Original paper]　Versatile photorearrangement of photocycloadducts from 5-fluoro-1,3-dimethyluracil and naphthalene.　K. Ohkura, H. Akizawa, M. Kudo, T. Ishihara, N. Oshima, K. Seki.　Heterocycles　84(2)　1057-1065　2012　
• [Original paper]　Synthesis and evaluation of diastereoisomers of 1,4,7-triazacyclononane-1,4,7-tris-(glutaric acid) (NOTGA) for multimeric radiopharmaceuticals of gallium.　F. L. Guerra Gomez, T. Uehara, T. Rokugawa, Y. Higaki, H. Suzuki, H. Hanaoka, H. Akizawa, Y. Arano.　Bioconjugate Chem.　23(11)　2229-2238　2012　
• [Original paper]　Radiolabeled uracil derivative as a novel SPECT probe for thymidine phosphorylase: Suppressed accumulation into tumor cells by target gene knockdown.　H. Li, S. Zhao, Y. Jin, K. Nishijima, H. Akizawa, K. Ohkura, N. Tamaki, Y. Kuge.　Nucl. Med. Commun.　32(12)　1211-1215　2011　
• [Original paper]　Toward in vivo imaging of heart disease using a radiolabeled single-chain Fv fragment targeting tenascin-C.　N. Kobayashi, K. Odaka, T. Uehara, K. Imanaka-Yoshida, Y. Kato, H. Oyama, H. Tadokoro, H. Akizawa, S. Tanada, M. Hiroe, T. Fukumura, I. Komuro, Y. Arano, T. Yoshida, T. Irie.　Anal. Chem.　83(23)　9123-9130　2011　

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Conference, etc.

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• [Oral presentation]　Development of ^99m Tc-labeled hexavalent c(RGDfK) peptide with optimized linker structure for in vivo imaging of integrin α_vβ₃　Yuki Mizuno, Kohta Kimura, Satoru Onoe, Miho Shukuri, Yuji Kuge, Hiromichi Akizawa　The Fourth International Symposium on Technetium and Other Radiometals in Chemistry and Medicine　Bressanone, Italy　2022/09/14～2022/09/17
• [Poster presentation]　Improvement of fatty acid binding protein-4 imaging probe having triazolopyrimidinone structure　Arisa Taguchi, Naoya Kondo, Tamami Sonoda, Satoru Onoe, Hiromichi Akizawa, Takashi Temma　The 142nd Annual Meeting the Pharmaceutical Society of Japan　Nagoya, Japan　2022/03/25～2022/03/28
• [Poster presentation]　The study on transporters involved in uptake of thymidine phosphorylase imaging agent ¹²³I-IIMU by using transporter transiently expressing cell lines　Mai Hasegawa, Miho Shukuri, Satoru Onoe, Yuki Mizuno, Yuji Kuge, Hiromichi Akizawa　The 142nd Annual Meeting the Pharmaceutical Society of Japan　Nagoya, Japan　2022/03/25～2022/03/28
• [Oral presentation]　2価環状RGDペプチドのスペーサ構造がintegrin αvβ3陽性細胞との相互作用に与える影響　水野雄貴、宮本莉里、尾江悟、宿里充穗、久下裕司、秋澤宏行　第4回日本核医学会分科会 放射性薬品科学研究会 第20回放射性医薬品?画像診断薬研究会　Sendai, Japan　2021/09/25
• [Poster presentation]　Fatty acid binding protein-4標的PETプローブの開発に向けた新規フッ化アリール結合triazolopyrimidine誘導体の合成　尾江悟?田中裕之?佐藤隆浩?水野雄貴?宿里充穗?近藤直哉?天滿敬?秋澤宏行　第65回日本薬学会関東支部大会　Chiba, Japan　2021/09/11
• [Oral presentation]　Influence of linker structure of multivalent RGD peptides on the interaction with integrin α_vβ₃ positive tumors　Yuki Mizuno, Kohta Kimura, Satoru Onoe, Miho Shukuri, Yuji Kuge, Hiromichi Akizawa　The 141st Annual Meeting the Pharmaceutical Society of Japan　Hiroshima, Japan　2021/03/26～2021/03/29
• [Poster presentation]　Development of Glyoxalase I-targeted SPECT probes: investigation of diester form of radioiodinated glutathione analogues　Kanon Takado, Satoru Onoe, Keisuke Sasano, Ayami Hirano, Miho Nagasaki, Yuki Mizuno, Miho Shukuri, Hiromichi Akizawa　The 141st Annual Meeting the Pharmaceutical Society of Japan　Hiroshima, Japan　2021/03/26～2021/03/29
• [Oral presentation]　Biodistribution of ¹¹¹In-DTPA-L-Phe^?1-Asp⁰-D-Phe¹-octreotide in tumor-bearing nude mice　Nobuhiro Oshima, Hiroki Shikanai, Yuji Kameyama, Hirotake Kitaura, Hiromichi Akizawa　The 140th Annual Meeting the Pharmaceutical Society of Japan　Kyoto, Japan　2020/03/25～2020/03/28
• [Poster presentation]　In vitro and in vivo evaluation of ¹¹¹In-1B4M-DTPA (tiuxetan)-conjugated octreotide derivatives for application to theranostics　Shiho Nakaue, Nobuhiro Oshima, Hiroki Shikanai, Masashi Shiba, Ryo Nakagawara, Kanta Yamamoto, Ryo Saito, Hirotake Kitaura, Hiromichi Akizawa　The 140th Annual Meeting the Pharmaceutical Society of Japan　Kyoto, Japan　2020/03/25～2020/03/28
• [Poster presentation]　Structure-cellular uptake relationship of ¹¹¹In-DTPA-AA^?1-Asp⁰-D-Phe¹-octreotide derivatives　Ryo Nakagawara, Nobuhiro Oshima, Shiho Nakaue, Yuu Ohmi, Fumihiro Kondo, Hirotake Kitaura, Hiromichi Akizawa　The 140th Annual Meeting the Pharmaceutical Society of Japan　Kyoto, Japan　2020/03/25～2020/03/28
• [Oral presentation]　The syntheses of Technetium(I)-99m complexes with chelating bidentate isonitrile ligands for molecular imaging 　Haruka Amemiya, Yuki Mizuno, Satoru Onoe, Miho Shukuri, Yasushi Arano, Hiromichi Akizawa　The 29th Symposium on Roles of Metals in Biological Reactions, Biology and Medicine　Osaka, Japan　2019/05/31～2019/06/01
• [Poster presentation]　Synthesis and preliminary evaluation of radioiodinated cyanine dyes for SPECT/fluorescence dual imaging of tumor　Shogo Kikuchi, Satoru Onoe, Sarina Nishi, Yuki Mizuno, Miho Shukuri, Hideo Saji, Hiromichi Akizawa 　The 139th Annual Meeting the Pharmaceutical Society of Japan　Chiba, Japan　2019/03/20～2019/03/23
• [Poster presentation]　The effect of linker length of multivalent RGD peptides on the uptake and retention in integrin αvβ3 positive cells　Kohta Kimura, Yuki Mizuno, Riri Miyamoto, Hiromichi Akizawa　The 139th Annual Meeting the Pharmaceutical Society of Japan　Chiba, Japan　2019/03/20～2019/03/23
• [Oral presentation]　Synthesis and evaluation of a ^99mTc-labeled hexavalent targeting probe from a monovalent ligand for in vivo imaging of saturable systems　Yuki Mizuno, Nagiho Komatsu, Tomoya Hehara, Hiromichi Akizawa, Yasushi Arano　The 3rd International Symposium on Technetium and Other Radiometals in Chemistry and Medicine The 3rd International Symposium on Technetium and Other Radiometals in Chemistry and Medicine　Bressanone, Italy　2018/09/26～2018/09/29
• [Poster presentation]　Preparation of hexacoordinated ^99mTc^I complexes using bidentate isonitrile ligands: Effect of linker structure on the radiolabeling yields　Haruka Amemiya, Yuki Mizuno, Yasushi Arano, Hiromichi Akizawa　The 138th Annual Meeting the Pharmaceutical Society of Japan　Kanazawa, Japan　2018/03/25～2018/03/28
• [Poster presentation]　Effect of organic cation transporters on tumor uptake of the thymidine phosphorylase imaging agent [¹²⁵I]-IIMU　Kenji Nakayama, Miho Shukuri, Kei Higashikawa, Satoru Onoe, Yuki Mizuno, Kazue Ohkura, Yuji Kuge, Hiromichi Akizawa　The 138th Annual Meeting the Pharmaceutical Society of Japan　Kanazawa, Japan　2018/03/25～2018/03/28
• [Poster presentation]　¹¹¹In-DTPA-L-Phe^－1-Asp⁰-D-Phe¹-octreotide の正常マウスでの体内動態および in vitro腫瘍集積性の評価　Nobuhiro Oshima, Yuji Kameyama, Hiroki Shikanai, Hirotake Kitaura, Hiromichi Akizawa, Kazue Ohkura　The 138th Annual Meeting the Pharmaceutical Society of Japan　Kanazawa, Japan　2018/03/25～2018/03/28
• [Poster presentation]　がん集積性シアニン系色素の放射性標識誘導体化に関する基礎的検討　紺野龍平、尾江悟、菊地正悟、布施有理、窪田奈々、秋澤宏行　第61回日本薬学会関東支部大会　東京　2017/09/16
• [Poster presentation]　Elucidation of control factors for photo-induced reactions between uracil derivatives and aromatics　Kazue Ohkura, Nobuhiro Oshima, Hirotake Kitaura, Hiromichi Akizawa, Koh-ichi Seki　The 97th CSJ Annual Meeting　Yokohama, Japan　2017/03/16～2017/03/19
• [Poster presentation]　放射性ヨウ素を導入したGlyoxalase I阻害剤の合成　平野愛耶美、尾江悟、鈴木友久、宿里充穗、秋澤宏行　第60回日本薬学会関東支部大会　東京　2016/09/17
• [Poster presentation]　¹¹¹In-DTPA-オクトレオチドの錯構造に基づく幾何異性体の相互変換と受容体親和性に関する検討　大島伸宏、河嶋秀和、秋澤宏行、久下裕司、大倉一枝　第55回日本核医学会学術総会　東京　2015/11/05～2015/11/07
• [Special lecture/Symposium]　Preclinical and Translational Researches of Novel PET and SPECT Tracers: ¹⁸F-FDiFA and ¹²³I-IIMU for Hypoxia and Thymidine Phosphorylase Imaging.　Songji Zhao, Ken-ichi Nishijima, Hiroki Matsumoto, Hiromichi Akizawa, Kazue Ohkura, Nagara Tamaki, Yuji Kuge　11th Asia Oceania Congress of Nuclear Medicine and Biology　Jeju, Korea　2015/10/31～2015/11/04
• [Oral presentation]　[¹¹¹In-DTPA-D-Phe¹-Asp⁰-D-Phe¹]-オクトレオチドの体内動態評価：放射能の腎集積性低減と腫瘍集積性の向上　大島伸宏、秋澤宏行、河嶋秀和、趙松吉、趙、西嶋剣一、北村陽二、荒野泰、久下裕司、大倉一枝　日本薬学会第135年会　神戸　2015/03/25～2015/03/28
• [Poster presentation]　Preclinical Evaluation of a Thymidine Phosphorylase Imaging Probe, [¹²³I]IIMU, for the First-in-Human clinical trials.　K. Nishijima, S. Zhao, F. Feng, Y. Shimizu, H. Akizawa, K. Ohkura, N. Kobashi, T. Abe, H. Matsumoto, N. Tamaki, Y. Kuge　The 12th International Symposium for Future Drug Discovery and Medical Care　札幌　2014/09/04～2014/09/05
• [Special lecture/Symposium]　生理活性放射性金属キレート化合物　北村陽二、秋澤宏行、竹中文章、榎本秀一　日本薬学会第134年会　熊本　2014/03/27～2014/03/30
• [Poster presentation]　テガフールとメトキシナフタレンとの光反応による新規付加体の生成　大倉一枝、秋澤宏行、菅生辰之、大島伸宏、関　興一　日本薬学会第134年会　熊本　2014/03/27～2014/03/30
• [Poster presentation]　Evaluation of a thymidine phosphorylase imaging agent, [¹²³I]IIMU, as a predictive marker for therapeutic efficacy of capecitabine　N. Kobashi, S. Meike, Y. Okumura, T. Abe, H. Akizawa, K. Ohkura, K. Nishijima, S. Zhao, Y. Kuge, H. Matsumoto　The 11th International Symposium for Future Drug Discovery and Medical Care　札幌　2013/08/01～2013/08/02
• [Poster presentation]　Preparation and evaluation of [¹²³I]IIMU for SPECT imaging of thymidine phosphorylase expression in tumors.　K. Nishijima, S. Zhao, Y. Zhao, F. Feng, Y. Shimizu, N. Abo, H. Akizawa, K. Ohkura, N. Tamaki, Y. Kuge　20th International Symposium on Radiopharmaceutical Sciences　Jeju, Korea　2013/05/12～2013/05/17
• [Poster presentation]　チミジンホスホリラーゼイメージング剤 [¹²³I]IIMUによるCapecitabineの治療効果予測　小橋信弥、女池俊介、奥村侑紀、阿部　務、秋澤宏行、大倉一枝、西嶋剣一、趙　松吉、久下裕司、松本博樹　日本薬学会第132年会　横浜　2013/03/27～2013/03/30
• [Poster presentation]　⁹⁰Y標識のための2-(p-aminobenzyl)-6-methyl-DTPA結合オクトレオチド誘導体の合成　大島伸宏、秋澤宏行、大倉一枝　日本薬学会第132年会　横浜　2013/03/27～2013/03/30
• [Poster presentation]　5-フルオロ-1,3-ジメチルウラシルとジメトキシナフタレンとの光反応における付加モード選択性　大倉一枝、相澤和也、秋澤宏行、関　興一　日本薬学会第132年会　横浜　2013/03/27～2013/03/30
• [Poster presentation]　Paterno-Büchi reaction of 3-uncapped 5-fluorouracils with methoxy naphthalenes.　K. Seki, T. Sugaoi, Y. Yoshida, H. Akizawa, K. Ohkura.　XXIV IUPAC Symposium on Photochemistry　Coimbra, Portugal　2012/07/15～2012/07/20
• [Poster presentation]　チミジンホスホリラーゼを標的とする新規腫瘍イメージング剤 (¹²³I-IIMU) の開発: マウス組織におけるチミジンホスホリラーゼ発現と^123/125I-IIMU集積との関係.　趙　松吉, 李　花, 西嶋剣一, 秋澤宏行, 大倉一枝, 玉木長良, 久下裕司.　第7回分子イメージング学会学術集会　浜松　2012/05/24～2012/05/25
• [Special lecture/Symposium]　放射性標識核酸誘導体による腫瘍の核医学診断と内用療法.（特別シンポジウム: 放射線を利用した画像診断?治療の最前線）　秋澤宏行, 趙　松吉, 高橋正幸, 西嶋剣一, 松本博樹, 関　興一, 玉木長良, 久下裕司, 大倉一枝.　日本薬学会第132年会　札幌　2012/03/28～2012/03/31
• [Poster presentation]　アスパラギン酸で負電荷を付与した¹¹¹In-DTPA-D-Phe¹-オクトレオチド誘導体の受容体親和性および体内動態の評価.　大島伸宏, 秋澤宏行, 趙　松吉, 趙　芫, 西嶋剣一, 北村陽二, 荒野　泰, 久下裕司, 大倉一枝.　日本薬学会第132年会　札幌　2012/03/28～2012/03/31
• [Poster presentation]　テガフールと1-メトキシナフタレンとの光反応によるナフチルピリミジンの生成.　大倉一枝, 藤岳夕歌, 大島伸宏, 秋澤宏行, 関　興一.　日本薬学会第132年会　札幌　2012/03/28～2012/03/31
• [Oral presentation]　チミジンホスホリラーゼイメージング剤 [¹²³I]5-iodo-6-[(2-iminoimidazolidinyl)methyl]uracilの開発: 血漿タンパク結合I-123標識合成検討.　西嶋剣一, 越田早織, 趙　松吉, 秋澤宏行, 大倉一枝, 松本博樹, 久下裕司.　第11回放射性医薬品?画像診断薬研究会　京都　2011/12/03
• [Poster presentation]　アスパラギン酸で負電荷を付与した¹¹¹In-DTPA-オクトレオチドの腎集積性およびin vitroにおける腫瘍集積性の評価.　大島伸宏, 秋澤宏行, 趙　松吉, 趙　芫, 藤岳夕歌, 西嶋剣一, 北村陽二, 荒野　泰, 久下裕司, 大倉一枝.　日本薬学会北海道支部第136回例会　札幌　2011/05/21
• [Poster presentation]　放射標識DOTA結合octreotide誘導体の腎集積低減に関する検討.　竹中文章, 北村陽二, 神野伸一郎, 秋澤宏行, 荒野　泰, 榎本秀一.　日本薬学会第131年会　静岡　2011/03/28～2011/03/31
• [Poster presentation]　1-メトキシナフタレンとウラシル類とのPaterno-Büchi型反応.　大倉一枝, 藤岳夕歌, 大島伸宏, 秋澤宏行, 関　興一.　日本化学会第91春季年会　横浜　2011/03/26～2011/03/29

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